{"id":"https://openalex.org/W4405489658","doi":"https://doi.org/10.1109/embc53108.2024.10782721","title":"Investigating the Impact of a Gut metabolite on Valvular Interstitial Cell Activation","display_name":"Investigating the Impact of a Gut metabolite on Valvular Interstitial Cell Activation","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405489658","doi":"https://doi.org/10.1109/embc53108.2024.10782721","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039168"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10782721","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782721","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115513484","display_name":"Samanvitha Deepthi Sudi","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samanvitha Deepthi Sudi","raw_affiliation_strings":["University of Florida,J. Crayton Pruitt Family Department of Biomedical Engineering,Gainesville,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida,J. Crayton Pruitt Family Department of Biomedical Engineering,Gainesville,USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tanmayee Kolli","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanmayee Kolli","raw_affiliation_strings":["University of Florida,J. Crayton Pruitt Family Department of Biomedical Engineering,Gainesville,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida,J. Crayton Pruitt Family Department of Biomedical Engineering,Gainesville,USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089174158","display_name":"Ana Maria Porras","orcid":"https://orcid.org/0000-0001-8226-623X"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Maria Porras","raw_affiliation_strings":["University of Florida,J. Crayton Pruitt Family Department of Biomedical Engineering,Gainesville,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida,J. Crayton Pruitt Family Department of Biomedical Engineering,Gainesville,USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45802211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.6895216703414917},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4476199150085449},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4386316239833832},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.32508140802383423},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1834765374660492},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14263799786567688}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6895216703414917},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4476199150085449},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4386316239833832},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32508140802383423},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1834765374660492},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14263799786567688}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10782721","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782721","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039168","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.550000011920929}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1521574455","https://openalex.org/W1984343582","https://openalex.org/W2018314802","https://openalex.org/W2047364237","https://openalex.org/W2078599166","https://openalex.org/W2171813323","https://openalex.org/W2548912871","https://openalex.org/W2588007963","https://openalex.org/W2596491901","https://openalex.org/W2778950327","https://openalex.org/W3095778980","https://openalex.org/W3189473074","https://openalex.org/W4205450657","https://openalex.org/W4214880684","https://openalex.org/W4221009295","https://openalex.org/W4281614799","https://openalex.org/W4309713348","https://openalex.org/W6807752833"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2160733843","https://openalex.org/W2545003596"],"abstract_inverted_index":{"Calcified":[0],"Aortic":[1],"Valve":[2],"Disease":[3],"(CAVD)":[4],"affects":[5],"up":[6],"to":[7,16,53,93,100,108,116,136,148,176],"13%":[8],"of":[9,165,179,187,193],"the":[10,25,39,57,62,163,177,185,191],"U.S.":[11],"population":[12],"and":[13,45,125,144],"is":[14],"linked":[15],"diet-induced":[17],"changes":[18],"in":[19,61,72,76,89,132,172,190],"metabolism.":[20],"Recent":[21],"studies":[22],"suggest":[23],"that":[24,49,156],"gut":[26,159],"metabolite":[27],"trimethyl":[28],"amine":[29],"oxide":[30],"(TMAO)":[31],"may":[32,51],"be":[33],"a":[34,73,158,169],"biomarker":[35],"for":[36],"atherosclerosis.":[37],"Given":[38],"shared":[40],"risk":[41],"factors":[42],"between":[43],"atherosclerosis":[44],"CAVD,":[46],"we":[47,102],"hypothesize":[48],"TMAO":[50,113,137],"contribute":[52],"CAVD":[54],"by":[55,98,120],"activating":[56],"primary":[58],"cell":[59],"type":[60],"valve,":[63],"valve":[64],"interstitial":[65],"cells":[66],"(VIC).":[67],"VICs":[68,80,111,146,167],"are":[69],"usually":[70],"found":[71],"quiescent":[74,110,166],"phenotype":[75,171],"healthy":[77],"valves;":[78],"however,":[79],"isolated":[81],"from":[82],"porcine":[83],"aortic":[84],"valves":[85],"exhibit":[86],"spontaneous":[87],"activation":[88,96,164],"traditional":[90],"culture.":[91,133],"Thus,":[92],"study":[94],"VIC":[95],"induced":[97],"exposure":[99],"TMAO,":[101,157],"first":[103],"applied":[104],"our":[105],"lab-engineered":[106],"protocol":[107],"generate":[109],"(qVICs).":[112],"treatment":[114,149],"led":[115],"qVIC":[117],"activation,":[118],"demonstrated":[119],"increased":[121],"\u03b1SMA":[122],"expression,":[123],"proliferation,":[124],"angiogenic":[126],"cytokine":[127],"secretion":[128],"after":[129],"3":[130],"days":[131],"The":[134],"response":[135],"was":[138],"not":[139],"sex-specific":[140],"with":[141,150],"both":[142],"male":[143],"female":[145],"responding":[147],"this":[151],"metabolite.":[152],"These":[153],"results":[154],"demonstrate":[155],"microbiome-derived":[160],"metabolite,":[161],"promotes":[162],"toward":[168],"myofibroblastic":[170],"vitro,":[173],"potentially":[174],"contributing":[175],"initiation":[178],"CAVD.":[180],"Overall,":[181],"these":[182],"findings":[183],"underscore":[184],"significance":[186],"host-microbe":[188],"interactions":[189],"progression":[192],"cardiovascular":[194],"disease.":[195]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2025-10-10T00:00:00"}
