{"id":"https://openalex.org/W4405488942","doi":"https://doi.org/10.1109/embc53108.2024.10782464","title":"Does EDPVR Represent Myocardial Tissue Stiffness? Toward a Better Definition","display_name":"Does EDPVR Represent Myocardial Tissue Stiffness? Toward a Better Definition","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405488942","doi":"https://doi.org/10.1109/embc53108.2024.10782464","pmid":"https://pubmed.ncbi.nlm.nih.gov/40040040"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10782464","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782464","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106879254","display_name":"Rana Raza Mehdi","orcid":"https://orcid.org/0000-0003-4835-0272"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rana Raza Mehdi","raw_affiliation_strings":["Texas A&amp;M University,Department of Biomedical Engineering,College Station,TX,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&amp;M University,Department of Biomedical Engineering,College Station,TX,USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024450291","display_name":"Emilio A. Mendiola","orcid":"https://orcid.org/0000-0002-7774-0811"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emilio A. Mendiola","raw_affiliation_strings":["Texas A&amp;M University,Department of Biomedical Engineering,College Station,TX,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&amp;M University,Department of Biomedical Engineering,College Station,TX,USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102793942","display_name":"Vahid Naeini","orcid":"https://orcid.org/0009-0005-7792-9154"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vahid Naeini","raw_affiliation_strings":["Texas A&amp;M University,Department of Biomedical Engineering,College Station,TX,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&amp;M University,Department of Biomedical Engineering,College Station,TX,USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006335310","display_name":"Gaurav Choudhary","orcid":"https://orcid.org/0000-0001-9343-5481"},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaurav Choudhary","raw_affiliation_strings":["Warren Alpert Medical School of Brown University,Division of Cardiology,Providence,RI,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School of Brown University,Division of Cardiology,Providence,RI,USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006348854","display_name":"Reza Avazmohammadi","orcid":"https://orcid.org/0000-0001-9787-1117"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reza Avazmohammadi","raw_affiliation_strings":["Texas A&amp;M University,Department of Biomedical Engineering,College Station,TX,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&amp;M University,Department of Biomedical Engineering,College Station,TX,USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.498382568359375},{"id":"https://openalex.org/keywords/stiffness","display_name":"Stiffness","score":0.46745166182518005},{"id":"https://openalex.org/keywords/structural-engineering","display_name":"Structural engineering","score":0.21348267793655396},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.16900300979614258}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.498382568359375},{"id":"https://openalex.org/C2779372316","wikidata":"https://www.wikidata.org/wiki/Q569057","display_name":"Stiffness","level":2,"score":0.46745166182518005},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.21348267793655396},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16900300979614258}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10782464","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782464","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40040040","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40040040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2023646532","https://openalex.org/W2102339840","https://openalex.org/W2755439793","https://openalex.org/W2893674051","https://openalex.org/W2952645301","https://openalex.org/W4220965910","https://openalex.org/W4290861649","https://openalex.org/W4319333986","https://openalex.org/W4380789019","https://openalex.org/W4381955165"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Accurate":[0],"assessment":[1,171,204],"of":[2,13,36,49,129,161,172,177,205],"myocardial":[3,37,50,68,183,206],"tissue":[4,69],"stiffness":[5,19,48,70],"is":[6],"pivotal":[7],"for":[8,88,109,158,168],"the":[9,23,46,66,89,122,127,130,173,189],"diagnosis":[10],"and":[11,73,96,121,149,175,201],"prognosis":[12],"heart":[14,104],"diseases.":[15],"Left":[16],"ventricular":[17],"diastolic":[18],"(\u03b2)":[20],"obtained":[21],"from":[22],"end-diastolic":[24],"pressure-volume":[25],"relationship":[26,118],"(EDPVR)":[27],"has":[28],"conventionally":[29],"been":[30],"utilized":[31],"as":[32,60],"a":[33,80,84,116,135,151,169,199],"representative":[34],"metric":[35],"stiffness.":[38,184,207],"The":[39],"EDPVR":[40],"can":[41],"be":[42],"employed":[43],"to":[44,106,139,180,191,197],"estimate":[45],"intrinsic":[47],"tissues":[51],"through":[52],"image-based":[53,101,193],"in-silico":[54,102,194],"inverse":[55],"optimization.":[56],"However,":[57],"whether":[58],"\u03b2,":[59],"an":[61],"organ-level":[62],"metric,":[63],"accurately":[64],"represents":[65],"tissue-level":[67,182],"in":[71,100],"healthy":[72],"diseased":[74],"myocardium":[75,90],"remains":[76],"elusive.":[77],"We":[78],"developed":[79],"modeling-based":[81],"approach":[82],"utilizing":[83],"two-parameter":[85],"material":[86,111,123],"model":[87],"(denoted":[91],"by":[92],"a<inf":[93,140,155,162],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[94,98,141,156,163],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">f</inf>":[95,157],"b<inf":[97],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">f</inf>)":[99],"biventricular":[103],"models":[105],"generate":[107],"EDPVRs":[108],"different":[110],"parameters.":[112,131],"Our":[113,185],"results":[114,186],"indicated":[115],"variable":[117],"between":[119],"\u03b2":[120,133],"parameters":[124],"depending":[125],"on":[126],"range":[128],"Interestingly,":[132],"showed":[134],"very":[136],"low":[137],"sensitivity":[138],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">f</inf>,":[142],"once":[143],"averaged":[144],"across":[145],"several":[146],"LV":[147],"geometries,":[148],"even":[150],"negative":[152],"correlation":[153],"with":[154],"small":[159],"values":[160],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">f</inf>.":[164],"These":[165],"findings":[166],"call":[167],"critical":[170],"reliability":[174],"confoundedness":[176],"EDPVR-derived":[178],"metrics":[179],"represent":[181],"also":[187],"underscore":[188],"necessity":[190],"explore":[192],"frameworks,":[195],"promising":[196],"provide":[198],"high-fidelity":[200],"potentially":[202],"non-invasive":[203]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}