{"id":"https://openalex.org/W4405488783","doi":"https://doi.org/10.1109/embc53108.2024.10782451","title":"Geno-GCN: A Genome-specific Graph Convolutional Network for Diabetes Prediction","display_name":"Geno-GCN: A Genome-specific Graph Convolutional Network for Diabetes Prediction","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405488783","doi":"https://doi.org/10.1109/embc53108.2024.10782451","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039720"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10782451","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782451","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089905899","display_name":"Kairui Guo","orcid":"https://orcid.org/0000-0003-1570-314X"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Kairui Guo","raw_affiliation_strings":["University of Technology Sydney,Australian Artificial Intelligence Institute, Faculty of Engineering and Information Technology,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Technology Sydney,Australian Artificial Intelligence Institute, Faculty of Engineering and Information Technology,Australia","institution_ids":["https://openalex.org/I114017466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067767936","display_name":"Hua Lin","orcid":"https://orcid.org/0000-0002-2899-0697"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Lin","raw_affiliation_strings":["23Strands Pty Ltd,New South Wales,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"23Strands Pty Ltd,New South Wales,Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024113714","display_name":"Mark Grosser","orcid":"https://orcid.org/0000-0002-4281-5369"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Grosser","raw_affiliation_strings":["23Strands Pty Ltd,New South Wales,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"23Strands Pty Ltd,New South Wales,Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062192039","display_name":"Guangquan Zhang","orcid":"https://orcid.org/0000-0003-3960-0583"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Guangquan Zhang","raw_affiliation_strings":["University of Technology Sydney,Australian Artificial Intelligence Institute, Faculty of Engineering and Information Technology,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Technology Sydney,Australian Artificial Intelligence Institute, Faculty of Engineering and Information Technology,Australia","institution_ids":["https://openalex.org/I114017466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100675577","display_name":"Jie L\u00fc","orcid":"https://orcid.org/0000-0003-0690-4732"},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jie Lu","raw_affiliation_strings":["University of Technology Sydney,Australian Artificial Intelligence Institute, Faculty of Engineering and Information Technology,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Technology Sydney,Australian Artificial Intelligence Institute, Faculty of Engineering and Information Technology,Australia","institution_ids":["https://openalex.org/I114017466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5089905899"],"corresponding_institution_ids":["https://openalex.org/I114017466"],"apc_list":null,"apc_paid":null,"fwci":0.6534,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.79923196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9883999824523926,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7252582907676697},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.511756181716919},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39894282817840576},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3436208963394165},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16145575046539307}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7252582907676697},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.511756181716919},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39894282817840576},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3436208963394165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16145575046539307}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10782451","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782451","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039720","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039720","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1644641054","https://openalex.org/W2554536751","https://openalex.org/W2767278854","https://openalex.org/W2952877743","https://openalex.org/W2965372631","https://openalex.org/W3002728042","https://openalex.org/W3152893301","https://openalex.org/W3191246504","https://openalex.org/W3216407895","https://openalex.org/W4200026682","https://openalex.org/W4237870467","https://openalex.org/W4280552086","https://openalex.org/W4283332321","https://openalex.org/W4283813541","https://openalex.org/W4313591046","https://openalex.org/W4386498736"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Drawing":[0],"inspiration":[1],"from":[2,73,76],"convolutional":[3,7,44],"neural":[4],"networks,":[5],"graph":[6,43],"networks":[8],"(GCNs)":[9],"have":[10],"been":[11],"implemented":[12],"in":[13,25,144],"various":[14],"applications.":[15],"Yet,":[16],"the":[17,26,53,116,135],"integration":[18],"of":[19,28,55,121],"GCNs":[20],"into":[21],"clinical":[22],"settings,":[23],"particularly":[24],"context":[27],"complex":[29],"health":[30],"conditions":[31],"like":[32],"diabetes,":[33],"remains":[34],"distant.":[35],"In":[36],"this":[37],"paper,":[38],"we":[39],"introduce":[40],"a":[41,48,84],"genome-specific":[42],"network":[45],"(Geno-GCN)":[46],"with":[47,89,138],"multi-graph":[49],"aggregator":[50],"to":[51],"predict":[52],"risk":[54,78],"developing":[56],"Type":[57],"2":[58],"diabetes":[59,77],"based":[60],"on":[61],"whole":[62],"genome":[63,98],"sequencing":[64],"data.":[65],"Geno-GCN":[66,94,132],"consolidates":[67],"both":[68],"positive":[69],"and":[70,100,108,119],"negative":[71,85],"influences":[72],"graphs":[74],"formulated":[75],"factors.":[79],"This":[80],"is":[81],"achieved":[82],"through":[83],"sample":[86],"strategy":[87],"combined":[88],"multi-view":[90],"aggregators.":[91],"We":[92],"assessed":[93],"using":[95],"Australia's":[96],"largest":[97],"bank":[99],"benchmarked":[101],"it":[102],"against":[103],"rule-based":[104],"methods,":[105],"bioinformatics":[106],"tools,":[107],"other":[109],"state-of-the-art":[110],"machine-learning":[111],"techniques.":[112],"The":[113],"results":[114],"demonstrated":[115],"superior":[117],"efficacy":[118],"robustness":[120],"our":[122],"method,":[123],"which":[124],"consistently":[125],"outperformed":[126],"competitors":[127],"across":[128],"all":[129],"evaluation":[130],"metrics.":[131],"also":[133],"exhibited":[134],"closest":[136],"alignment":[137],"actual":[139],"labels,":[140],"showcasing":[141],"its":[142],"potential":[143],"large":[145],"population":[146],"studies.":[147]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-03T08:25:01.440150","created_date":"2025-10-10T00:00:00"}