{"id":"https://openalex.org/W4405489495","doi":"https://doi.org/10.1109/embc53108.2024.10782358","title":"In silico drug delivery modeling of a novel Everolimus Coated Balloon","display_name":"In silico drug delivery modeling of a novel Everolimus Coated Balloon","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405489495","doi":"https://doi.org/10.1109/embc53108.2024.10782358","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039502"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10782358","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782358","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115513464","display_name":"Grigorios G. Kotoulas","orcid":null},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Grigorios G. Kotoulas","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece"],"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091064880","display_name":"Vasileios S. Loukas","orcid":"https://orcid.org/0000-0001-6390-884X"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vasileios S. Loukas","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece"],"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088807604","display_name":"Georgia S. Karanasiou","orcid":"https://orcid.org/0000-0001-9478-0375"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgia S. Karanasiou","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece"],"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079931924","display_name":"Antonis I. Sakellarios","orcid":"https://orcid.org/0000-0002-2272-9543"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Antonis I. Sakellarios","raw_affiliation_strings":["University of Patras,Laboratory of Biomechanics and Biomedical Engineering,Department of Mechanical and Aeronautics Engineering,Patras,Greece"],"affiliations":[{"raw_affiliation_string":"University of Patras,Laboratory of Biomechanics and Biomedical Engineering,Department of Mechanical and Aeronautics Engineering,Patras,Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074234790","display_name":"Vasileios C. Pezoulas","orcid":"https://orcid.org/0000-0002-1872-693X"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vasileios C. Pezoulas","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece"],"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059700503","display_name":"Christos S. Katsouras","orcid":"https://orcid.org/0000-0001-7638-9217"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christos C. Katsouras","raw_affiliation_strings":["University of Ioannina,Medical School,Dept. of Cardiology,Ioannina,GR,Greece"],"affiliations":[{"raw_affiliation_string":"University of Ioannina,Medical School,Dept. of Cardiology,Ioannina,GR,Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108147230","display_name":"Lambros K. Michalis","orcid":null},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Lambros K. Michalis","raw_affiliation_strings":["University of Ioannina,Medical School,Dept. of Cardiology,Ioannina,GR,Greece"],"affiliations":[{"raw_affiliation_string":"University of Ioannina,Medical School,Dept. of Cardiology,Ioannina,GR,Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084683488","display_name":"Arsen Semertzioglou","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arsen Semertzioglou","raw_affiliation_strings":["Rontis Corporation S.A,Larisa,Greece"],"affiliations":[{"raw_affiliation_string":"Rontis Corporation S.A,Larisa,Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081783984","display_name":"Anargyros N. Moulas","orcid":"https://orcid.org/0000-0002-4681-6174"},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anargyros Moulas","raw_affiliation_strings":["University of Thessaly,General Department,Larisa,Greece"],"affiliations":[{"raw_affiliation_string":"University of Thessaly,General Department,Larisa,Greece","institution_ids":["https://openalex.org/I145722265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030220964","display_name":"Liesbet Geris","orcid":"https://orcid.org/0000-0002-8180-1445"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Liesbet Geris","raw_affiliation_strings":["University of Liège KU Leuven,Department of Biomechanics and Computational Tissue Engineering,Belgium"],"affiliations":[{"raw_affiliation_string":"University of Liège KU Leuven,Department of Biomechanics and Computational Tissue Engineering,Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037813012","display_name":"Dimitrios I. Fotiadis","orcid":"https://orcid.org/0000-0002-7362-5082"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios I. Fotiadis","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece"],"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece","institution_ids":["https://openalex.org/I194019607"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5115513464"],"corresponding_institution_ids":["https://openalex.org/I194019607"],"apc_list":null,"apc_paid":null,"fwci":0.5662,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.73490678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9578999876976013,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11338","display_name":"Advancements in Photolithography Techniques","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8105322122573853},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.6634462475776672},{"id":"https://openalex.org/keywords/everolimus","display_name":"Everolimus","score":0.6427115201950073},{"id":"https://openalex.org/keywords/balloon","display_name":"Balloon","score":0.5674846768379211},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.48811349272727966},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47390568256378174},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.36591702699661255},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.2419717013835907},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2333226203918457},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.21895822882652283},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.18787771463394165},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.16505131125450134},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.10663461685180664}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8105322122573853},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6634462475776672},{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.6427115201950073},{"id":"https://openalex.org/C139059822","wikidata":"https://www.wikidata.org/wiki/Q183951","display_name":"Balloon","level":2,"score":0.5674846768379211},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48811349272727966},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47390568256378174},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.36591702699661255},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2419717013835907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2333226203918457},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21895822882652283},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18787771463394165},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.16505131125450134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10663461685180664},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10782358","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782358","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039502","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1964491483","https://openalex.org/W2011517547","https://openalex.org/W2095791911","https://openalex.org/W2749851477","https://openalex.org/W2751054365","https://openalex.org/W2897148831","https://openalex.org/W2924466413","https://openalex.org/W2999951240","https://openalex.org/W3040859983","https://openalex.org/W3086218297","https://openalex.org/W3092758776","https://openalex.org/W3118430413","https://openalex.org/W3126528864","https://openalex.org/W3154669308","https://openalex.org/W4223494124","https://openalex.org/W4280540099","https://openalex.org/W4282021512","https://openalex.org/W4284994469","https://openalex.org/W4294647318","https://openalex.org/W4311653217","https://openalex.org/W4327963690","https://openalex.org/W4386980655","https://openalex.org/W6755059079"],"related_works":["https://openalex.org/W2110077817","https://openalex.org/W1996770357","https://openalex.org/W2008367989","https://openalex.org/W2392653027","https://openalex.org/W2154968513","https://openalex.org/W2766008346","https://openalex.org/W2126726246","https://openalex.org/W4388540673","https://openalex.org/W2751083078","https://openalex.org/W2434802039"],"abstract_inverted_index":{"This":[0],"study":[1,103],"examines":[2],"the":[3,29,76,80,84,88,101,108,117,132,138,150,156,170,200,214],"drug":[4,77,85,126,168,185,197],"elution":[5],"process":[6],"of":[7,21,52,75,100,125,152,169,216],"a":[8,16,70,180],"novel":[9,17,217],"Everolimus":[10,27,112,153,157],"Coated":[11,219],"Balloon":[12,220],"(ECB)":[13],"that":[14,73,195],"features":[15],"polymer":[18],"mixture":[19],"consisting":[20],"cellulose":[22],"derivatives":[23],"and":[24,26,64,83,94,110,120,129,146,154],"accelerators,":[25],"as":[28,121],"pharmaceutical":[30],"component,":[31],"based":[32,148],"on":[33,149],"commercially":[34],"available":[35],"PTCA":[36,57],"balloon-catheter":[37],"system.":[38],"In":[39],"this":[40,177,207],"analysis,":[41],"we":[42],"utilized":[43,211],"in":[44,142,176,199],"silico":[45],"postdeployment":[46],"results":[47,99],"comprising":[48],"three":[49],"distinct":[50],"datasets":[51],"healthy":[53],"porcine":[54],"arteries":[55],"undergoing":[56],"with":[58,163],"(a)":[59,106],"Sirolimus,":[60,155],"(b)":[61,147],"Low-dose":[62],"Everolimus,":[63],"(c)":[65],"High-dose":[66],"Everolimus.":[67],"We":[68],"developed":[69],"computational":[71],"model":[72],"consists":[74],"release":[78,186],"from":[79,187],"balloon":[81,140],"surface":[82],"transport":[86],"through":[87],"porous":[89],"arterial":[90,133,171],"wall":[91,134],"given":[92],"advection":[93],"diffusion":[95],"properties.":[96],"The":[97],"comparative":[98],"current":[102],"highlight":[104],"that:":[105],"among":[107],"high":[109],"low-dose":[111],"Eluting":[113,158],"Balloons,":[114],"diffusivity":[115,151],"is":[116,127,179],"governing":[118],"property":[119],"such,":[122],"respective":[123],"amount":[124],"eluted":[128],"bound":[130,167],"by":[131],"-":[135],"effectively":[136],"rendering":[137],"high-dose":[139],"powerful":[141],"its":[143],"delivery":[144],"properties,":[145],"Balloons":[159],"exhibit":[160],"superior":[161],"performance":[162],"respect":[164],"to":[165,203,212],"total":[166],"wall.Clinical":[172],"Relevance-The":[173],"approach":[174],"described":[175],"article":[178],"step":[181],"farther":[182],"toward":[183],"precision":[184],"DCB":[188],"prediction.":[189],"Furthermore,":[190],"our":[191],"study's":[192],"findings":[193],"demonstrate":[194],"higher":[196,204],"concentration":[198],"coating":[201],"leads":[202],"binding":[205],"amounts;":[206],"information":[208],"could":[209],"be":[210],"inform":[213],"creation":[215],"Drug":[218],"(DCB).":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-03T22:45:19.894376","created_date":"2025-10-10T00:00:00"}