{"id":"https://openalex.org/W4405488872","doi":"https://doi.org/10.1109/embc53108.2024.10782247","title":"Structural and biocompatibility challenges for 3D printed microfluidic devices for IVF","display_name":"Structural and biocompatibility challenges for 3D printed microfluidic devices for IVF","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405488872","doi":"https://doi.org/10.1109/embc53108.2024.10782247","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039657"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10782247","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782247","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://eprints.whiterose.ac.uk/223221/1/EMBC2024Mancinelli.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050077461","display_name":"Elena Mancinelli","orcid":"https://orcid.org/0000-0002-0530-1924"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elena Mancinelli","raw_affiliation_strings":["University of Leeds,School of Electronic and Electrical Engineering,Leeds,United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leeds,School of Electronic and Electrical Engineering,Leeds,United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andreia Santos Miranda","orcid":null},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andreia Santos Miranda","raw_affiliation_strings":["University of Leeds,School of Medicine,Leeds,United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leeds,School of Medicine,Leeds,United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048153314","display_name":"Helen M. Picton","orcid":"https://orcid.org/0000-0002-7593-775X"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen M. Picton","raw_affiliation_strings":["University of Leeds,Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine,Leeds,United Kingdom UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leeds,Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine,Leeds,United Kingdom UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034208192","display_name":"Virginia Pensabene","orcid":"https://orcid.org/0000-0002-3352-8202"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Virginia Pensabene","raw_affiliation_strings":["University of Leeds,School of Electronic and Electrical Engineering,Leeds,United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leeds,School of Electronic and Electrical Engineering,Leeds,United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130828816"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9671000242233276,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9671000242233276,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10783","display_name":"Additive Manufacturing and 3D Printing Technologies","score":0.917900025844574,"subfield":{"id":"https://openalex.org/subfields/2203","display_name":"Automotive Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biocompatibility","display_name":"Biocompatibility","score":0.7879672050476074},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.6471214294433594},{"id":"https://openalex.org/keywords/3d-printed","display_name":"3d printed","score":0.5298694968223572},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44064366817474365},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.4041484594345093},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.38434287905693054},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3177991509437561},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1743365228176117}],"concepts":[{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.7879672050476074},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.6471214294433594},{"id":"https://openalex.org/C3019308078","wikidata":"https://www.wikidata.org/wiki/Q229367","display_name":"3d printed","level":2,"score":0.5298694968223572},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44064366817474365},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4041484594345093},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38434287905693054},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3177991509437561},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1743365228176117},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc53108.2024.10782247","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782247","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039657","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:eprints.whiterose.ac.uk:223221","is_oa":true,"landing_page_url":null,"pdf_url":"https://eprints.whiterose.ac.uk/223221/1/EMBC2024Mancinelli.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Proceedings Paper"}],"best_oa_location":{"id":"pmh:oai:eprints.whiterose.ac.uk:223221","is_oa":true,"landing_page_url":null,"pdf_url":"https://eprints.whiterose.ac.uk/223221/1/EMBC2024Mancinelli.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Proceedings Paper"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.5400000214576721,"display_name":"Affordable and clean energy"}],"awards":[{"id":"https://openalex.org/G7886759280","display_name":null,"funder_award_id":"MR/X502789/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405488872.pdf","grobid_xml":"https://content.openalex.org/works/W4405488872.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2032947008","https://openalex.org/W2045423466","https://openalex.org/W2111872922","https://openalex.org/W2122339603","https://openalex.org/W2162995726","https://openalex.org/W2166713989","https://openalex.org/W2167076112","https://openalex.org/W2296186698","https://openalex.org/W2782489123","https://openalex.org/W2800091803","https://openalex.org/W3160795150","https://openalex.org/W3183855134","https://openalex.org/W4205717756","https://openalex.org/W4256298201","https://openalex.org/W6799358274"],"related_works":["https://openalex.org/W2393655250","https://openalex.org/W2393417063","https://openalex.org/W2561756220","https://openalex.org/W2365560514","https://openalex.org/W2998489467","https://openalex.org/W1998250559","https://openalex.org/W2917354508","https://openalex.org/W2067214849","https://openalex.org/W2039688101","https://openalex.org/W2497443468"],"abstract_inverted_index":{"In":[0],"Vitro":[1],"Fertilization":[2],"(IVF)":[3],"is":[4],"a":[5,52,74,111],"widely":[6],"used":[7],"treatment":[8,31],"for":[9,14,122],"infertility,":[10],"but":[11],"success":[12],"rates":[13],"UK":[15],"women":[16],"under":[17],"35":[18],"stand":[19],"at":[20],"approximately":[21],"32%.":[22],"Culture":[23],"conditions":[24],"significantly":[25],"affect":[26],"in-vitro":[27],"embryo":[28,66,139],"development":[29,60],"and":[30,91,102],"efficacy.":[32],"Over":[33],"40":[34],"years,":[35],"IVF":[36],"procedures":[37],"evolved,":[38],"with":[39,78,105],"microfluidic":[40,75,126],"platforms":[41],"emerging":[42],"to":[43,50,136],"enhance":[44],"culture":[45],"conditions.":[46],"These":[47],"platforms,":[48],"designed":[49],"mimic":[51],"natural":[53],"environment,":[54],"show":[55],"promise":[56],"without":[57],"negatively":[58],"affecting":[59],"rates.":[61],"However,":[62,128],"potential":[63],"impacts":[64],"on":[65],"characteristics":[67],"require":[68],"further":[69],"evaluation.":[70],"The":[71],"study":[72],"introduces":[73],"concept":[76],"compatible":[77],"time-lapse":[79],"microscopy.":[80],"Two":[81],"prototyping":[82],"methods":[83],"are":[84,134],"compared,":[85],"being":[86],"soft":[87,107],"lithography":[88],"in":[89,94,120],"PDMS":[90],"3D":[92,115],"printing":[93,116],"HTL":[95],"resin.":[96,143],"Results":[97],"indicate":[98],"successful":[99],"prototype":[100],"detection":[101],"loading":[103],"efficiency,":[104],"the":[106,142],"lithographic":[108],"method":[109],"showing":[110],"lower":[112],"assembly":[113],"yield.":[114],"facilitates":[117],"rapid":[118],"design,":[119],"particular":[121],"high":[123],"aspect":[124],"ratio":[125],"devices.":[127],"viability":[129],"assessments":[130],"suggest":[131],"additional":[132],"steps":[133],"required":[135],"exclude":[137],"material":[138],"toxicity":[140],"of":[141]},"counts_by_year":[],"updated_date":"2026-07-19T07:52:34.831488","created_date":"2025-10-10T00:00:00"}