{"id":"https://openalex.org/W4405488813","doi":"https://doi.org/10.1109/embc53108.2024.10782171","title":"Investigation of the significance of the plaque morphology evolution in plaque rupture events using computational biomechanics","display_name":"Investigation of the significance of the plaque morphology evolution in plaque rupture events using computational biomechanics","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405488813","doi":"https://doi.org/10.1109/embc53108.2024.10782171","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039211"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10782171","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782171","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059959470","display_name":"Dimitrios S. Pleouras","orcid":"https://orcid.org/0000-0002-8000-8218"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios S. Pleouras","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060566170","display_name":"Panagiotis K. Siogkas","orcid":"https://orcid.org/0000-0002-0343-0984"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis K. Siogkas","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071147257","display_name":"Vassiliki T. Potsika","orcid":null},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vassiliki T. Potsika","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114033974","display_name":"Vasilis D. Tsakanikas","orcid":null},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vasilis D. Tsakanikas","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115513327","display_name":"Sokratis S. Dimos","orcid":null},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Sokratis S. Dimos","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060613837","display_name":"Michalis D. Mantzaris","orcid":null},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Michalis D. Mantzaris","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027492092","display_name":"Igor Kon\u010dar","orcid":"https://orcid.org/0000-0002-4873-2775"},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Igor Koncar","raw_affiliation_strings":["University of Belgrade,Faculty of Medicine,Department of Vascular and Endovascular Surgery,Belgrade,Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Belgrade,Faculty of Medicine,Department of Vascular and Endovascular Surgery,Belgrade,Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037813012","display_name":"Dimitrios I. Fotiadis","orcid":"https://orcid.org/0000-0002-7362-5082"},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios I. Fotiadis","raw_affiliation_strings":["University of Ioannina,Unit of Medical Technology and Intelligent Information Systems, Biomedical Research Institute FORTH,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ioannina,Unit of Medical Technology and Intelligent Information Systems, Biomedical Research Institute FORTH,Dept. of Materials Science and Engineering,Ioannina,Greece,GR45110","institution_ids":["https://openalex.org/I194019607"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4935,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.71568352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9822999835014343,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomechanics","display_name":"Biomechanics","score":0.7618446946144104},{"id":"https://openalex.org/keywords/morphology","display_name":"Morphology (biology)","score":0.6743150353431702},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3388960659503937},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19247666001319885},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.18843743205070496},{"id":"https://openalex.org/keywords/zoology","display_name":"Zoology","score":0.05822789669036865}],"concepts":[{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.7618446946144104},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.6743150353431702},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3388960659503937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19247666001319885},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.18843743205070496},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.05822789669036865}],"mesh":[{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10782171","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782171","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039211","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039211","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1966164421","https://openalex.org/W1980654125","https://openalex.org/W2035142337","https://openalex.org/W2037566088","https://openalex.org/W2087518289","https://openalex.org/W2131484662","https://openalex.org/W2162874261","https://openalex.org/W2560219472","https://openalex.org/W2886970585","https://openalex.org/W2931421228","https://openalex.org/W2940614632","https://openalex.org/W2980116008","https://openalex.org/W3092886167","https://openalex.org/W4389537819"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3014307317","https://openalex.org/W2668228314","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W1537355970"],"abstract_inverted_index":{"Forwarded":[0],"by":[1],"the":[2,30,47,60,68,81,115,136,156,158,163,166,171,179,183,203,208],"technological":[3],"urge":[4],"of":[5,20,29,49,59,83,117,138,216],"this":[6,23,74],"era,":[7],"several":[8,39,50],"computational":[9,40],"methods":[10],"are":[11,42,191],"implemented":[12],"to":[13,66,79,169,194,220,229],"give":[14],"further":[15],"insights":[16,228],"into":[17],"possible":[18],"outcomes":[19,51],"diseases.":[21],"In":[22,73],"context,":[24],"atherosclerosis,":[25],"which":[26],"is":[27,35,64,108],"one":[28,58,142,148],"most":[31,61],"fatal":[32],"diseases":[33],"nowadays,":[34],"treated":[36],"alike,":[37],"where":[38],"models":[41,63],"proposed":[43],"annually":[44],"allowing":[45],"for":[46,52,231],"evaluation":[48,157],"patient":[53,131,140],"specific":[54,132],"cases.":[55],"Among":[56],"them,":[57],"significant":[62],"able":[65],"predict":[67],"atherosclerotic":[69],"evolution":[70,100,146,152],"over":[71,162],"time.":[72],"proof-of-concept":[75,199],"study,":[76],"we":[77],"aim":[78],"investigate":[80],"effect":[82],"plaque":[84,87,99,120,145,151,172],"morphology":[85],"on":[86,110],"rupture":[88,173,218],"in":[89,101,129],"a":[90,94,97,111,118,213],"two-case":[91],"scenario":[92],"-":[93],"longitudinal":[95,144],"and":[96,126,147,165],"bulk":[98,150],"3D-reconstructed":[102],"patient-specific":[103],"carotids":[104],"arteries.":[105],"Our":[106],"approach":[107],"based":[109],"three-step":[112],"process:":[113],"i)":[114],"implementation":[116],"state-of-the-art":[119],"growth":[121],"model":[122],"that":[123,178,202,205,222],"predicts":[124],"evolving":[125,180],"new":[127],"plaques":[128,164,181,204,221],"real":[130],"carotid":[133],"arteries,":[134],"ii)":[135],"selection":[137],"2":[139],"cases,":[141],"with":[143,149,212],"and,":[153],"finally,":[154],"iii)":[155],"maximum":[159],"principal":[160],"stress":[161],"endothelium":[167],"layers":[168],"assess":[170],"risk.":[174],"The":[175],"results":[176],"indicate":[177],"towards":[182,207],"lumen,":[184],"not":[185],"only":[186],"cause":[187],"stenoses":[188],"but":[189],"also":[190],"more":[192],"prone":[193],"rupture.":[195],"Clinical":[196],"relevance-":[197],"This":[198],"work":[200],"establishes":[201],"grow":[206,223],"luminal":[209],"border":[210],"present":[211],"higher":[214],"risk":[215],"potential":[217,236],"compared":[219],"longitudinally,":[224],"thus":[225],"giving":[226],"valuable":[227],"clinicians":[230],"important":[232],"decision":[233],"making":[234],"regarding":[235],"endarterectomy":[237],"procedures.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-12T08:23:45.883708","created_date":"2025-10-10T00:00:00"}