{"id":"https://openalex.org/W4405489649","doi":"https://doi.org/10.1109/embc53108.2024.10782012","title":"Ensuring Model Fairness via Stratified Training: TP53 Mutation Prediction with Estrogen Receptor Stratification in Breast Histopathology","display_name":"Ensuring Model Fairness via Stratified Training: TP53 Mutation Prediction with Estrogen Receptor Stratification in Breast Histopathology","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405489649","doi":"https://doi.org/10.1109/embc53108.2024.10782012","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039878"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10782012","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782012","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037295300","display_name":"Nikos Tsiknakis","orcid":"https://orcid.org/0000-0002-7581-467X"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Nikos Tsiknakis","raw_affiliation_strings":["Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100381632","display_name":"Kang Wang","orcid":"https://orcid.org/0000-0001-5401-1803"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kang Wang","raw_affiliation_strings":["Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046277340","display_name":"Dimitrios Salgkamis","orcid":"https://orcid.org/0000-0002-3020-0359"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Dimitrios Salgkamis","raw_affiliation_strings":["Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005682217","display_name":"Evangelos Tzoras","orcid":"https://orcid.org/0009-0005-2109-4725"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Evangelos Tzoras","raw_affiliation_strings":["Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016219588","display_name":"Georgios C. Manikis","orcid":"https://orcid.org/0000-0002-3396-0644"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Georgios C. Manikis","raw_affiliation_strings":["Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009958595","display_name":"Emmanouil G. Sifakis","orcid":"https://orcid.org/0000-0001-9919-4471"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Emmanouil Sifakis","raw_affiliation_strings":["Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071571360","display_name":"Jonas Bergh","orcid":"https://orcid.org/0000-0001-5526-1847"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jonas Bergh","raw_affiliation_strings":["Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082110835","display_name":"Ioannis Zerdes","orcid":"https://orcid.org/0000-0002-8304-2462"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ioannis Zerdes","raw_affiliation_strings":["Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014640458","display_name":"Kostas Marias","orcid":"https://orcid.org/0000-0003-3783-5223"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Kostas Marias","raw_affiliation_strings":["Institute of Computer Science, Foundation for Research and Technology Hellas,Heraklion,Greece,70013"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Computer Science, Foundation for Research and Technology Hellas,Heraklion,Greece,70013","institution_ids":["https://openalex.org/I8901234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039948885","display_name":"Alexios Matikas","orcid":"https://orcid.org/0000-0002-4122-9624"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Alexios Matikas","raw_affiliation_strings":["Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060114464","display_name":"Theodoros Foukakis","orcid":"https://orcid.org/0000-0001-8952-9987"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Theodoros Foukakis","raw_affiliation_strings":["Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology-Pathology, Karolinska Institutet,Stockholm,Sweden,17177","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3055,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.67652953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histopathology","display_name":"Histopathology","score":0.6050816178321838},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"Estrogen receptor","score":0.5891666412353516},{"id":"https://openalex.org/keywords/stratification","display_name":"Stratification (seeds)","score":0.5743357539176941},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"Risk stratification","score":0.473632276058197},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44261249899864197},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3436456322669983},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.32157087326049805},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.3108212351799011},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22010433673858643},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2009200155735016},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.14359408617019653}],"concepts":[{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.6050816178321838},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5891666412353516},{"id":"https://openalex.org/C192943249","wikidata":"https://www.wikidata.org/wiki/Q1893382","display_name":"Stratification (seeds)","level":5,"score":0.5743357539176941},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.473632276058197},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44261249899864197},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3436456322669983},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32157087326049805},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3108212351799011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22010433673858643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2009200155735016},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14359408617019653},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C3527866","wikidata":"https://www.wikidata.org/wiki/Q162267","display_name":"Dormancy","level":3,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C88548481","wikidata":"https://www.wikidata.org/wiki/Q2397491","display_name":"Seed dormancy","level":4,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10782012","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782012","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039878","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5400000214576721,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W2052193554","https://openalex.org/W2093347382","https://openalex.org/W2096079397","https://openalex.org/W2114473143","https://openalex.org/W2343160907","https://openalex.org/W2530395818","https://openalex.org/W2531897166","https://openalex.org/W2963263347","https://openalex.org/W2963446712","https://openalex.org/W2987972529","https://openalex.org/W3043835773","https://openalex.org/W3113328935","https://openalex.org/W3135547872","https://openalex.org/W3176719058","https://openalex.org/W3186679119","https://openalex.org/W3201382058","https://openalex.org/W3211647829","https://openalex.org/W4220843931","https://openalex.org/W4302307280","https://openalex.org/W4312765357","https://openalex.org/W4320036931","https://openalex.org/W4361215239","https://openalex.org/W4387030598","https://openalex.org/W4389543108","https://openalex.org/W6726497184","https://openalex.org/W6728551298","https://openalex.org/W6803426362","https://openalex.org/W6845767997","https://openalex.org/W6857222836"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W3039419443","https://openalex.org/W4386772532","https://openalex.org/W4393212117","https://openalex.org/W2115661411","https://openalex.org/W2399391471","https://openalex.org/W2033590167","https://openalex.org/W1583810757","https://openalex.org/W2001086065","https://openalex.org/W2366529083"],"abstract_inverted_index":{"Developing":[0],"AI":[1],"models":[2,63,91],"on":[3,67,98,106],"medical":[4],"images":[5],"as":[6],"decision":[7],"support":[8],"systems":[9],"has":[10],"seen":[11],"a":[12],"huge":[13],"increase":[14],"in":[15,49],"interest":[16],"during":[17],"the":[18,29,42,68,71,107],"last":[19],"few":[20],"years.":[21],"However,":[22],"most":[23,56],"published":[24,62],"studies":[25],"have":[26,64],"neglected":[27],"testing":[28,75],"model's":[30],"robustness":[31],"against":[32],"certain":[33],"dataset-related":[34],"biases":[35,79],"and":[36,101,120,123],"unbalanced":[37],"variables.":[38],"For":[39],"example,":[40],"although":[41],"prevalence":[43],"of":[44,70,104,109],"TP53":[45,94],"mutations":[46],"is":[47,111],"higher":[48],"Estrogen":[50],"Receptor":[51],"(ER)-negative":[52],"breast":[53],"cancer,":[54],"while":[55,116],"ER-positive":[57],"tumors":[58],"are":[59],"not":[60],"mutated,":[61],"been":[65],"developed":[66],"entirety":[69],"available":[72],"data":[73],"without":[74],"for":[76,93,113],"such":[77],"intrinsic":[78],"that":[80,90,102],"can":[81],"lead":[82],"to":[83],"overfitting.":[84],"In":[85],"this":[86],"study":[87],"we":[88],"show":[89],"trained":[92],"mutation":[95],"prediction":[96],"overfit":[97],"ER":[99,110],"status":[100],"stratification":[103],"training":[105],"basis":[108],"beneficial":[112],"all":[114],"subgroups":[115],"it":[117],"reduces":[118],"bias":[119],"increases":[121],"generalizability":[122],"fairness.":[124],"(Implementation:":[125],"https://github.com/tsikup/er-stratified-training-tp53-prediction).":[126]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
