{"id":"https://openalex.org/W4405488600","doi":"https://doi.org/10.1109/embc53108.2024.10782010","title":"A closed-loop micropump and flow meter for high-precision drug delivery in an implantable neural probe","display_name":"A closed-loop micropump and flow meter for high-precision drug delivery in an implantable neural probe","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405488600","doi":"https://doi.org/10.1109/embc53108.2024.10782010","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039659"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10782010","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782010","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109446247","display_name":"Mohammad Makhdoumi Akram","orcid":"https://orcid.org/0000-0002-3637-3963"},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Mohammad Makhdoumi Akram","raw_affiliation_strings":["Universit&#x00E9; Laval,Department of Electrical and Computer Engineering,Quebec,Canada,G1V0A6"],"affiliations":[{"raw_affiliation_string":"Universit&#x00E9; Laval,Department of Electrical and Computer Engineering,Quebec,Canada,G1V0A6","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010360162","display_name":"Amir Aghajani","orcid":null},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amir Aghajani","raw_affiliation_strings":["Universit&#x00E9; Laval,Department of Electrical and Computer Engineering,Quebec,Canada,G1V0A6"],"affiliations":[{"raw_affiliation_string":"Universit&#x00E9; Laval,Department of Electrical and Computer Engineering,Quebec,Canada,G1V0A6","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035258088","display_name":"Wei Shi","orcid":"https://orcid.org/0000-0001-9106-1092"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Shi","raw_affiliation_strings":["Universit&#x00E9; Laval,Center for Optics, Photonics and Lasers (COPL),Quebec,Canada,G1V0A6"],"affiliations":[{"raw_affiliation_string":"Universit&#x00E9; Laval,Center for Optics, Photonics and Lasers (COPL),Quebec,Canada,G1V0A6","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018071134","display_name":"Benoit Gosselin","orcid":"https://orcid.org/0000-0003-1473-3451"},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Benoit Gosselin","raw_affiliation_strings":["Universit&#x00E9; Laval,Department of Electrical and Computer Engineering,Quebec,Canada,G1V0A6"],"affiliations":[{"raw_affiliation_string":"Universit&#x00E9; Laval,Department of Electrical and Computer Engineering,Quebec,Canada,G1V0A6","institution_ids":["https://openalex.org/I43406934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109446247"],"corresponding_institution_ids":["https://openalex.org/I43406934"],"apc_list":null,"apc_paid":null,"fwci":0.196,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.51310273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micropump","display_name":"Micropump","score":0.889310896396637},{"id":"https://openalex.org/keywords/closed-loop","display_name":"Closed loop","score":0.5585407614707947},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.5101235508918762},{"id":"https://openalex.org/keywords/loop","display_name":"Loop (graph theory)","score":0.5042303800582886},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48099860548973083},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.4637359380722046},{"id":"https://openalex.org/keywords/flow-measurement","display_name":"Flow measurement","score":0.4527393579483032},{"id":"https://openalex.org/keywords/flow","display_name":"Flow (mathematics)","score":0.45249128341674805},{"id":"https://openalex.org/keywords/feedback-loop","display_name":"Feedback loop","score":0.4379946291446686},{"id":"https://openalex.org/keywords/metre","display_name":"Metre","score":0.43532052636146545},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4262838065624237},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.33046215772628784},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.2893252372741699},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.26913008093833923},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.2578061819076538},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.24842306971549988},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.21541857719421387},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20958450436592102},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.14073455333709717},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11140665411949158}],"concepts":[{"id":"https://openalex.org/C76272257","wikidata":"https://www.wikidata.org/wiki/Q1933964","display_name":"Micropump","level":2,"score":0.889310896396637},{"id":"https://openalex.org/C3019251811","wikidata":"https://www.wikidata.org/wiki/Q5135346","display_name":"Closed loop","level":2,"score":0.5585407614707947},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5101235508918762},{"id":"https://openalex.org/C184670325","wikidata":"https://www.wikidata.org/wiki/Q512604","display_name":"Loop (graph theory)","level":2,"score":0.5042303800582886},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48099860548973083},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4637359380722046},{"id":"https://openalex.org/C16302685","wikidata":"https://www.wikidata.org/wiki/Q15091623","display_name":"Flow measurement","level":2,"score":0.4527393579483032},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.45249128341674805},{"id":"https://openalex.org/C186886427","wikidata":"https://www.wikidata.org/wiki/Q5441213","display_name":"Feedback loop","level":2,"score":0.4379946291446686},{"id":"https://openalex.org/C151011524","wikidata":"https://www.wikidata.org/wiki/Q11573","display_name":"Metre","level":2,"score":0.43532052636146545},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4262838065624237},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.33046215772628784},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2893252372741699},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.26913008093833923},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2578061819076538},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.24842306971549988},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.21541857719421387},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20958450436592102},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14073455333709717},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11140665411949158},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004129","descriptor_name":"Dimethylpolysiloxanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004129","descriptor_name":"Dimethylpolysiloxanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004129","descriptor_name":"Dimethylpolysiloxanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015918","descriptor_name":"Infusion Pumps, Implantable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10782010","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10782010","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039659","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6499999761581421}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2026229157","https://openalex.org/W2077128382","https://openalex.org/W2980128763","https://openalex.org/W2989901716","https://openalex.org/W3084845131","https://openalex.org/W3123007245","https://openalex.org/W4213189560","https://openalex.org/W4288428132"],"related_works":["https://openalex.org/W2379622005","https://openalex.org/W2365509988","https://openalex.org/W2405362194","https://openalex.org/W2076529279","https://openalex.org/W1978584881","https://openalex.org/W2331792489","https://openalex.org/W2375992089","https://openalex.org/W2035469321","https://openalex.org/W2558015143","https://openalex.org/W2577112555"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"a":[3,11,37,69],"closed-loop":[4],"micropump":[5],"system":[6],"and":[7,25,35],"flow":[8,22,45,58],"meter":[9,46],"with":[10,68],"proportional-integral-derivative":[12],"(PID)":[13],"controller":[14,82],"is":[15,47,62],"introduced":[16],"to":[17,65,91],"improve":[18],"the":[19,50,54,80,84],"accuracy":[20,85],"of":[21,41,71,79,86],"rate":[23,59],"measurement":[24],"drug":[26,38,87],"delivery.":[27],"The":[28,57,77],"micropumps":[29],"are":[30],"fabricated":[31],"using":[32],"Polydimethylsiloxane":[33],"(PDMS)":[34],"have":[36],"reservoir":[39],"capacity":[40],"7\u00b5L.":[42],"A":[43],"capacitance-based":[44],"employed":[48],"as":[49],"feedback":[51],"mechanism":[52],"for":[53],"PID":[55,81],"controller.":[56],"range":[60],"investigated":[61],"between":[63],"15":[64],"45":[66],"pL/min,":[67],"resolution":[70],"1.2":[72],"pF":[73],"per":[74],"100":[75],"pL/min.":[76],"implementation":[78],"enhances":[83],"delivery":[88],"by":[89],"up":[90],"27%.":[92]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2025-12-27T23:08:20.325037","created_date":"2025-10-10T00:00:00"}
