{"id":"https://openalex.org/W4405489139","doi":"https://doi.org/10.1109/embc53108.2024.10781848","title":"Voltage Independent Depth Control and Acute Lesion Formation Findings in Epicardial Pulsed Field Ablation System for Surgical Ablations","display_name":"Voltage Independent Depth Control and Acute Lesion Formation Findings in Epicardial Pulsed Field Ablation System for Surgical Ablations","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405489139","doi":"https://doi.org/10.1109/embc53108.2024.10781848","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039957"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10781848","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10781848","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11883168/pdf/nihms-2043853.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092347598","display_name":"Daniel Laurita","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Laurita","raw_affiliation_strings":["Case Western Reserve University,Biomedical Engineering,Cleveland,US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Biomedical Engineering,Cleveland,US","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080489982","display_name":"Celeen M. Khrestian","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celeen Khrestian","raw_affiliation_strings":["Cardiology Case Western Reserve University,Cleveland,US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Case Western Reserve University,Cleveland,US","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023677035","display_name":"Dragan Juzbasich","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dragan Juzbasich","raw_affiliation_strings":["Cardiology Case Western Reserve University,Cleveland,US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Case Western Reserve University,Cleveland,US","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103402634","display_name":"Seungyup Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seungyup Lee","raw_affiliation_strings":["Case Western Reserve University,Cardiology and Biomedical Engineering,Cleveland,US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Cardiology and Biomedical Engineering,Cleveland,US","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41827226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ablation","display_name":"Ablation","score":0.8007709980010986},{"id":"https://openalex.org/keywords/lesion","display_name":"Lesion","score":0.5781751275062561},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.49404340982437134},{"id":"https://openalex.org/keywords/voltage","display_name":"Voltage","score":0.4733857214450836},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.45627206563949585},{"id":"https://openalex.org/keywords/radiofrequency-ablation","display_name":"Radiofrequency ablation","score":0.4348353147506714},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4111720621585846},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3871016502380371},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3618999719619751},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.22051453590393066},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.15567082166671753},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1141204833984375}],"concepts":[{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.8007709980010986},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5781751275062561},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49404340982437134},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.4733857214450836},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.45627206563949585},{"id":"https://openalex.org/C2777377203","wikidata":"https://www.wikidata.org/wiki/Q1809554","display_name":"Radiofrequency ablation","level":3,"score":0.4348353147506714},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4111720621585846},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3871016502380371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3618999719619751},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22051453590393066},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.15567082166671753},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1141204833984375}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D010496","descriptor_name":"Pericardium","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc53108.2024.10781848","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10781848","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039957","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11883168","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11883168","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11883168/pdf/nihms-2043853.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annu Int Conf IEEE Eng Med Biol Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11883168","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11883168","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11883168/pdf/nihms-2043853.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annu Int Conf IEEE Eng Med Biol Soc","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2445557043","display_name":null,"funder_award_id":"HL146463","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3047014093","display_name":null,"funder_award_id":"HL167672","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306479","display_name":"Elisabeth Severance Prentiss Foundation","ror":"https://ror.org/015z1nq23"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405489139.pdf","grobid_xml":"https://content.openalex.org/works/W4405489139.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W2106414997","https://openalex.org/W2137434301","https://openalex.org/W2162622568","https://openalex.org/W2759628821","https://openalex.org/W2910092598","https://openalex.org/W3199309974","https://openalex.org/W4214726821","https://openalex.org/W4295136261","https://openalex.org/W4323294621","https://openalex.org/W4377010952","https://openalex.org/W4377234437"],"related_works":["https://openalex.org/W2913786724","https://openalex.org/W2977374089","https://openalex.org/W3145441801","https://openalex.org/W2357783023","https://openalex.org/W2013863777","https://openalex.org/W2118389769","https://openalex.org/W4394573179","https://openalex.org/W3150504402","https://openalex.org/W3020408180","https://openalex.org/W2904133969"],"abstract_inverted_index":{"Pulsed":[0],"Field":[1],"Ablation":[2],"(PFA)":[3],"is":[4,18,25,72],"a":[5],"novel":[6],"ablation":[7,52],"technology":[8],"that":[9,97],"utilizes":[10],"electric":[11,36],"field":[12],"strength":[13],"to":[14,35,49,56,66,74,80,87,118,138],"ablate":[15,58,78],"tissue.":[16],"PFA":[17,38,93,102,111,147],"unique":[19],"in":[20,27,45],"its":[21,46,50],"cell":[22],"selectivity,":[23],"which":[24,156],"found":[26],"the":[28,31,64,89,92,95,106,140],"biophysics":[29],"of":[30,43,60,91,143],"bilipid":[32],"membrane's":[33],"sensitivity":[34],"fields.":[37],"permits":[39],"an":[40],"unseen":[41],"level":[42,142],"flexibility":[44],"delivery":[47],"due":[48],"non-abrasive":[51],"methods":[53],"and":[54,77,105,124,161],"ability":[55,65],"selectively":[57],"regardless":[59],"direct":[61],"contact.":[62],"With":[63],"electrically":[67],"isolate":[68],"each":[69],"electrode,":[70],"it":[71],"possible":[73],"dynamically":[75],"map":[76],"according":[79],"patient-specific":[81],"\"mechanistic\"":[82],"targets.":[83],"Testing":[84],"was":[85],"done":[86],"determine":[88],"efficacy":[90],"system,":[94],"influence":[96],"electrode":[98,122],"configuration":[99,123],"has":[100],"on":[101],"lesion":[103,108,112],"size,":[104],"acute":[107],"formation":[109],"timeline.":[110],"depth":[113,152],"can":[114],"be":[115],"doubled":[116],"(1mm":[117],"2mm)":[119],"through":[120],"modulating":[121],"polarity.":[125],"Significant":[126],"electrophysiological":[127],"changes":[128],"were":[129],"only":[130],"recorded":[131],"immediately":[132],"post":[133],"ablation.":[134],"Electrode":[135],"configurations":[136],"appeared":[137],"generate":[139],"same":[141],"tissue":[144],"damage":[145],"at":[146],"sites":[148],"while":[149],"significantly":[150],"increasing":[151,154],"without":[153],"voltage,":[155],"could":[157],"introduce":[158],"more":[159],"risks":[160],"complications.":[162]},"counts_by_year":[],"updated_date":"2026-06-21T07:57:09.225873","created_date":"2025-10-10T00:00:00"}