{"id":"https://openalex.org/W4405489666","doi":"https://doi.org/10.1109/embc53108.2024.10781691","title":"Low intensity focused ultrasound stimulation targeted on M1 ameliorates neuroinflammation in hemi-parkinsonian rats","display_name":"Low intensity focused ultrasound stimulation targeted on M1 ameliorates neuroinflammation in hemi-parkinsonian rats","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405489666","doi":"https://doi.org/10.1109/embc53108.2024.10781691","pmid":"https://pubmed.ncbi.nlm.nih.gov/40038987"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10781691","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10781691","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018823699","display_name":"Chunchan Li","orcid":"https://orcid.org/0009-0003-9528-2185"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunchan Li","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021026281","display_name":"Tianyi Sun","orcid":"https://orcid.org/0009-0000-9152-7382"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyi Sun","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100896044","display_name":"Rong Liang","orcid":null},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Liang","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zihui Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zihui Yang","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Weifan Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weifan Yang","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015936466","display_name":"Wanzhe Li","orcid":null},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanzhe Li","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067876451","display_name":"Yiwei Yin","orcid":"https://orcid.org/0000-0002-1914-7577"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwei Yin","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100330893","display_name":"Guanglu Zhang","orcid":"https://orcid.org/0000-0001-7067-2257"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanglu Zhang","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398717","display_name":"Ling Wang","orcid":"https://orcid.org/0000-0003-1035-5633"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Wang","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068826437","display_name":"Jiajia Yang","orcid":"https://orcid.org/0000-0001-5439-7136"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Yang","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023574333","display_name":"Feng He","orcid":"https://orcid.org/0000-0001-8359-2635"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng He","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"last","author":{"id":null,"display_name":"Dong Ming","orcid":null},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Ming","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine,Tianjin,China,300072","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20233555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.6507999897003174,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.6507999897003174,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.13439999520778656,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"Neuroinflammation","score":0.7889087796211243},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.6931963562965393},{"id":"https://openalex.org/keywords/intensity","display_name":"Intensity (physics)","score":0.5221822261810303},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.48960238695144653},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.42836278676986694},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.40244466066360474},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.30724942684173584},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2136249542236328},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10261556506156921},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.08123779296875},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.050013452768325806}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7889087796211243},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6931963562965393},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.5221822261810303},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.48960238695144653},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42836278676986694},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40244466066360474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30724942684173584},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2136249542236328},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10261556506156921},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.08123779296875},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.050013452768325806},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069453","descriptor_name":"Ultrasonic Waves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069453","descriptor_name":"Ultrasonic Waves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069453","descriptor_name":"Ultrasonic Waves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10781691","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10781691","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40038987","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40038987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5099999904632568,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W2015026123","https://openalex.org/W2089845241","https://openalex.org/W2753051298","https://openalex.org/W2904404980","https://openalex.org/W2906406205","https://openalex.org/W2922876238","https://openalex.org/W2957671901","https://openalex.org/W3010106631","https://openalex.org/W3010966623","https://openalex.org/W3014859431","https://openalex.org/W3096174158","https://openalex.org/W3150546220","https://openalex.org/W3177002540","https://openalex.org/W4205118098","https://openalex.org/W4210490571","https://openalex.org/W4323567648","https://openalex.org/W4386070362"],"related_works":["https://openalex.org/W4390463473","https://openalex.org/W2807379694","https://openalex.org/W4221075899","https://openalex.org/W163337889","https://openalex.org/W4386839975","https://openalex.org/W3206087933","https://openalex.org/W2230859375","https://openalex.org/W1980457166","https://openalex.org/W2115523377","https://openalex.org/W2035158409"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Low":[1],"intensity":[2],"focused":[3],"stimulation":[4],"(LIFUS)":[5],"has":[6],"been":[7],"proved":[8],"to":[9,25,87,103,118,151],"improve":[10,37,197],"motor":[11,33,38,90],"function":[12],"in":[13,40,56,108,126,134,145,153,170,179,215],"Parkinson's":[14],"disease":[15],"(PD)":[16],"animal":[17],"modules.":[18],"The":[19,45,95,111],"aim":[20],"of":[21,53,92,97,122,200],"this":[22],"study":[23,205],"is":[24],"investigate":[26],"whether":[27],"LIFUS":[28,67,139,164],"target":[29],"on":[30,70,191],"the":[31,41,57,65,89,93,105,109,120,127,135,142,149,154,159,166,180],"primary":[32],"cortex":[34],"(M1)":[35],"can":[36,193],"deficit":[39],"PD":[42,46,71,161,201],"rats.":[43,94,162,202],"METHODS:":[44],"rat":[47],"model":[48],"was":[49,68,116],"induced":[50],"by":[51],"injection":[52],"6-hydroxydopamine":[54],"(6-OHDA)":[55],"medial":[58],"forebrain":[59],"bundle":[60],"(MFB).":[61],"Two":[62],"weeks":[63],"after":[64,182],"injection,":[66],"used":[69],"rats":[72],"for":[73,211],"two":[74],"weeks.":[75],"Behavioral":[76],"tests":[77],"were":[78,101],"performed":[79],"including":[80],"open":[81],"field":[82],"test":[83,86],"and":[84,99,131,147,172,196],"rotarod":[85,155],"examine":[88],"ability":[91],"activity":[96],"microglia":[98,171],"astrocyte":[100,173],"tested":[102],"evaluate":[104],"inflammation":[106,167],"level":[107],"brain.":[110],"tyrosine":[112],"hydroxylase":[113],"(TH)":[114],"staining":[115],"done":[117],"detect":[119],"recovery":[121],"dopaminergic":[123],"(DA)":[124],"neurons":[125],"substantia":[128],"nigra":[129],"(SN)":[130],"DA":[132],"fibers":[133,177],"striatum":[136],"(STR).":[137],"RESULTS:":[138],"treatment":[140],"decreased":[141],"resting":[143],"time":[144],"OFT(p<0.05)":[146],"increased":[148,178],"latency":[150],"falls":[152],"test(p<0.05)":[156],"compared":[157],"with":[158],"untreated":[160],"Moreover,":[163],"reduced":[165],"response":[168],"reflected":[169],"activation.":[174],"Additionally,":[175],"TH-immunoreactive":[176],"STR":[181],"LIFUS.":[183],"CONCLUSION:":[184],"These":[185],"findings":[186],"demonstrated":[187],"that":[188],"LIPUS":[189],"targeted":[190],"M1":[192],"inhibit":[194],"neuroinflammation":[195],"movement":[198],"disorders":[199],"SIGNIFICANCE:":[203],"This":[204],"provides":[206],"a":[207],"new":[208],"therapeutic":[209],"strategy":[210],"further":[212],"clinical":[213],"application":[214],"PD.":[216]},"counts_by_year":[],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}