{"id":"https://openalex.org/W4405489566","doi":"https://doi.org/10.1109/embc53108.2024.10781585","title":"Chronic Spinal Cord Injury Increases Spontaneous Intraspinal Neural Transmission and Spike Train Variability","display_name":"Chronic Spinal Cord Injury Increases Spontaneous Intraspinal Neural Transmission and Spike Train Variability","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405489566","doi":"https://doi.org/10.1109/embc53108.2024.10781585","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039548"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10781585","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10781585","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003396511","display_name":"Maria F. Bandres","orcid":"https://orcid.org/0000-0003-1806-7783"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria F. Bandres","raw_affiliation_strings":["Washington University School of Medicine,Program in Physical Therapy,Dept. of Biomedical Engineering,St. Louis,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine,Program in Physical Therapy,Dept. of Biomedical Engineering,St. Louis,USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023366843","display_name":"Jacob G. McPherson","orcid":"https://orcid.org/0000-0002-4554-7531"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacob G. McPherson","raw_affiliation_strings":["Washingon Univ. Pain Ctr Washington University School of Medicine,Prog. Physical Therapy,Dept. of Anesthesiology; Prog. Neurosciences; Dept. of Biomed. Eng.,St. Louis,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washingon Univ. Pain Ctr Washington University School of Medicine,Prog. Physical Therapy,Dept. of Anesthesiology; Prog. Neurosciences; Dept. of Biomed. Eng.,St. Louis,USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43529412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord","display_name":"Spinal cord","score":0.633282482624054},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"Spinal cord injury","score":0.6312201023101807},{"id":"https://openalex.org/keywords/spike","display_name":"Spike (software development)","score":0.6080950498580933},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4879609942436218},{"id":"https://openalex.org/keywords/neurophysiology","display_name":"Neurophysiology","score":0.4561331868171692},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4548930525779724},{"id":"https://openalex.org/keywords/transmission","display_name":"Transmission (telecommunications)","score":0.43902239203453064},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.41112518310546875},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.36182379722595215},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3460614085197449},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18996462225914001},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15624529123306274},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.08593890070915222}],"concepts":[{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.633282482624054},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.6312201023101807},{"id":"https://openalex.org/C2781390188","wikidata":"https://www.wikidata.org/wiki/Q25203449","display_name":"Spike (software development)","level":2,"score":0.6080950498580933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4879609942436218},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.4561331868171692},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4548930525779724},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.43902239203453064},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.41112518310546875},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.36182379722595215},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3460614085197449},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18996462225914001},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15624529123306274},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.08593890070915222},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10781585","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10781585","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039548","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.49000000953674316,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W83679122","https://openalex.org/W1985177015","https://openalex.org/W1998794714","https://openalex.org/W2007592542","https://openalex.org/W2029010014","https://openalex.org/W2037702549","https://openalex.org/W2136104104","https://openalex.org/W2172201406","https://openalex.org/W2528857413","https://openalex.org/W3164470634","https://openalex.org/W3189679457","https://openalex.org/W4306147066","https://openalex.org/W4365137626","https://openalex.org/W4366428241"],"related_works":["https://openalex.org/W2174331923","https://openalex.org/W2050175337","https://openalex.org/W2915014248","https://openalex.org/W2329992713","https://openalex.org/W3050304047","https://openalex.org/W2317338006","https://openalex.org/W2385487847","https://openalex.org/W2386002113","https://openalex.org/W3034714285","https://openalex.org/W2382449071"],"abstract_inverted_index":{"Spinal":[0],"cord":[1],"injury":[2],"(SCI)":[3],"often":[4],"leads":[5],"to":[6,13,20,90,149,171],"increased":[7,180],"spontaneous":[8,145],"activity":[9],"(SpAP)":[10],"and":[11,23,45,59,100,109,115,135,159,184,195],"responsiveness":[12],"sensory":[14,191],"feedback.":[15],"This":[16],"hyperexcitable":[17],"state":[18],"contributes":[19],"the":[21,36,42,55,60,81,85,95,124,128,150,156,176],"development":[22],"maintenance":[24],"of":[25,33,38,84,98,127,199],"SCI-related":[26],"neuropathic":[27],"pain":[28],"(SCI-NP).":[29],"In":[30],"general,":[31],"characterizations":[32],"SpAP":[34,53,79,122,181],"in":[35,52,54,78,103,105,155,182],"context":[37],"SCI-NP":[39,142],"focus":[40],"on":[41],"dorsal":[43,99,183],"horns":[44],"sensory-processing":[46],"neurons.":[47],"As":[48],"a":[49,197],"result,":[50],"changes":[51],"integrative":[56],"intermediate":[57],"gray":[58,87,130],"motor-dominant":[61],"ventral":[62,101,157,185],"horn":[63],"after":[64,132,193],"SCI":[65,113,134,165,194],"are":[66],"considerably":[67],"less":[68],"understood.":[69],"Thus,":[70],"it":[71],"is":[72],"unclear":[73],"whether":[74],"altered":[75],"firing":[76,96],"dynamics":[77,97],"throughout":[80,123],"dorso-ventral":[82],"extent":[83,126],"spinal":[86,129],"matter":[88,131],"contribute":[89],"SCI-NP.":[91,117,200],"Here":[92],"we":[93],"characterize":[94],"interneurons":[102],"vivo":[104],"neurologically":[106,172],"intact":[107,173],"rats":[108,110],"with":[111,114,141,163],"chronic":[112,133,136,164],"without":[116],"We":[118],"find":[119],"(1)":[120],"robust":[121],"dorsoventral":[125],"SCI-NP;":[137],"(2)":[138],"that":[139,161,179],"animals":[140,162],"showed":[143],"higher":[144,167],"discharge":[146],"rates":[147],"compared":[148,170],"other":[151],"animal":[152],"groups,":[153],"particularly":[154],"horns;":[158],"(3)":[160],"exhibited":[166],"neuronal":[168],"variability":[169],"animals.":[174],"Together,":[175],"results":[177],"suggest":[178],"neurons":[186],"may":[187],"further":[188],"exacerbate":[189],"pathological":[190],"transmission":[192],"be":[196],"component":[198]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2025-10-10T00:00:00"}
