{"id":"https://openalex.org/W4405490030","doi":"https://doi.org/10.1109/embc53108.2024.10781578","title":"Investigating the impact of sickle cell disease on red blood cell transport in complex capillary networks","display_name":"Investigating the impact of sickle cell disease on red blood cell transport in complex capillary networks","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405490030","doi":"https://doi.org/10.1109/embc53108.2024.10781578","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039263"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10781578","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10781578","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045213775","display_name":"Runxin Wu","orcid":"https://orcid.org/0009-0008-1945-413X"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Runxin Wu","raw_affiliation_strings":["Duke University,Biomedical Engineering,Durham,NC,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University,Biomedical Engineering,Durham,NC,USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108083376","display_name":"Mamun Kabir","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed Shihab Kabir","raw_affiliation_strings":["Duke University,Biomedical Engineering,Durham,NC,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University,Biomedical Engineering,Durham,NC,USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023772133","display_name":"George A. Truskey","orcid":"https://orcid.org/0000-0002-6885-4489"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George A. Truskey","raw_affiliation_strings":["Duke University,Biomedical Engineering,Durham,NC,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University,Biomedical Engineering,Durham,NC,USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056497188","display_name":"Amanda Randles","orcid":"https://orcid.org/0000-0001-6318-3885"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Randles","raw_affiliation_strings":["Duke University,Biomedical Engineering,Durham,NC,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University,Biomedical Engineering,Durham,NC,USA","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5602512359619141},{"id":"https://openalex.org/keywords/red-blood-cell","display_name":"Red blood cell","score":0.5507814884185791},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.45778384804725647},{"id":"https://openalex.org/keywords/red-cell","display_name":"Red Cell","score":0.4369010031223297},{"id":"https://openalex.org/keywords/capillary-action","display_name":"Capillary action","score":0.43476805090904236},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37136414647102356},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3085547685623169},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.27151381969451904},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24597135186195374},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17093461751937866},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.1571081578731537},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14837443828582764},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1201498806476593}],"concepts":[{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5602512359619141},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.5507814884185791},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45778384804725647},{"id":"https://openalex.org/C2777208419","wikidata":"https://www.wikidata.org/wiki/Q4347672","display_name":"Red Cell","level":2,"score":0.4369010031223297},{"id":"https://openalex.org/C196806460","wikidata":"https://www.wikidata.org/wiki/Q188603","display_name":"Capillary action","level":2,"score":0.43476805090904236},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37136414647102356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3085547685623169},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27151381969451904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24597135186195374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17093461751937866},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1571081578731537},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14837443828582764},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1201498806476593},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10781578","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10781578","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039263","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2007170047","https://openalex.org/W2020639348","https://openalex.org/W2022513670","https://openalex.org/W2081632499","https://openalex.org/W2153730006","https://openalex.org/W2293067660","https://openalex.org/W2622488958","https://openalex.org/W2768830599","https://openalex.org/W2944030358","https://openalex.org/W2995031681","https://openalex.org/W3047045307","https://openalex.org/W3099487260","https://openalex.org/W4239647010","https://openalex.org/W4283837991","https://openalex.org/W4306738655","https://openalex.org/W4313459884","https://openalex.org/W4388031358","https://openalex.org/W4389127811"],"related_works":["https://openalex.org/W2042664965","https://openalex.org/W2003120471","https://openalex.org/W4246490354","https://openalex.org/W2418575076","https://openalex.org/W2152677811","https://openalex.org/W202011109","https://openalex.org/W2390838093","https://openalex.org/W2007796665","https://openalex.org/W2400749554","https://openalex.org/W1996509571"],"abstract_inverted_index":{"Sickle":[0],"cell":[1,10,96,158],"disease":[2],"encompasses":[3],"a":[4,76,94],"variety":[5],"of":[6],"inherited":[7],"red":[8],"blood":[9,30,46,53],"(RBC)":[11],"disorders":[12],"characterized":[13],"by":[14],"abnormal":[15,29],"thrombosis,":[16],"microvascular":[17],"occlusion,":[18],"end-organ":[19],"ischemia,":[20],"and":[21,32,42,56,89,122,150],"early":[22],"mortality.":[23],"Understanding":[24],"how":[25,69],"sickle":[26,70,90,95,107,157],"RBCs":[27,108],"drive":[28],"flow":[31,54],"stress":[33,126],"on":[34],"the":[35,84,114],"endothelial":[36],"wall":[37,124],"is":[38],"essential":[39],"to":[40,82,99],"predict":[41],"prevent":[43],"blockages":[44],"in":[45,75,141,154],"circulation.":[47],"While":[48],"there":[49,63],"are":[50,64],"studies":[51],"comparing":[52],"velocity":[55],"pressure":[57],"via":[58],"computational":[59,132],"fluid":[60,118],"dynamics":[61],"simulations,":[62],"still":[65],"open":[66],"questions":[67],"about":[68],"cells":[71],"interact":[72],"with":[73,156],"plasma":[74],"complex":[77,142],"capillary":[78,143],"network.":[79],"In":[80],"order":[81],"quantify":[83],"hemodynamic":[85,139],"differences":[86],"between":[87],"normal":[88],"cells,":[91],"we":[92],"introduced":[93],"RBC":[97],"model":[98,133],"massively":[100],"parallel":[101],"fluid-structure":[102],"interaction":[103],"software":[104],"HARVEY.":[105],"Notably,":[106],"exhibit":[109],"increased":[110],"margination,":[111],"aggregation":[112],"at":[113,127],"inner":[115],"curvature,":[116],"slower":[117],"velocity,":[119],"higher":[120],"pressure,":[121],"greater":[123],"shear":[125],"standard":[128],"hematocrit":[129],"levels.":[130],"This":[131],"facilitates":[134],"detailed":[135],"cellular":[136],"modeling":[137],"for":[138],"simulations":[140],"networks,":[144],"offering":[145],"predictive":[146],"insight":[147],"into":[148],"blockage":[149],"potential":[151],"vessel":[152],"ruptures":[153],"patients":[155],"disease.":[159]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
