{"id":"https://openalex.org/W4405489212","doi":"https://doi.org/10.1109/embc53108.2024.10781539","title":"The Pattern of CA1 c-Fos Expressing Place Cells Correlates with Learning Progression","display_name":"The Pattern of CA1 c-Fos Expressing Place Cells Correlates with Learning Progression","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4405489212","doi":"https://doi.org/10.1109/embc53108.2024.10781539","pmid":"https://pubmed.ncbi.nlm.nih.gov/40039517"},"language":"en","primary_location":{"id":"doi:10.1109/embc53108.2024.10781539","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10781539","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021872901","display_name":"Ning Wang","orcid":"https://orcid.org/0000-0003-4741-2216"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Wang","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine, Medical College,Tianjin,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine, Medical College,Tianjin,China","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016463901","display_name":"Anqi Zhang","orcid":"https://orcid.org/0000-0002-5878-3728"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anqi Zhang","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine, Medical College,Tianjin,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine, Medical College,Tianjin,China","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101869500","display_name":"Jiajia Yang","orcid":"https://orcid.org/0000-0002-6112-9647"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Yang","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine, Medical College,Tianjin,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine, Medical College,Tianjin,China","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081587154","display_name":"Ling Wang","orcid":"https://orcid.org/0000-0002-2532-6467"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Wang","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine, Medical College,Tianjin,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine, Medical College,Tianjin,China","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002715805","display_name":"Chenguang Zheng","orcid":"https://orcid.org/0000-0002-4782-8732"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenguang Zheng","raw_affiliation_strings":["Tianjin University,Academy of Medical Engineering and Translational Medicine, Medical College,Tianjin,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin University,Academy of Medical Engineering and Translational Medicine, Medical College,Tianjin,China","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I162868743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9890999794006348,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9699000120162964,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5177032947540283},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32273879647254944}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5177032947540283},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32273879647254944}],"mesh":[{"descriptor_ui":"D000071037","descriptor_name":"Place Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071037","descriptor_name":"Place Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc53108.2024.10781539","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc53108.2024.10781539","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:40039517","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40039517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1917541791","https://openalex.org/W1980006923","https://openalex.org/W2082235945","https://openalex.org/W2151239423","https://openalex.org/W2155505956","https://openalex.org/W2299967951","https://openalex.org/W2883712683","https://openalex.org/W3199432935","https://openalex.org/W4293004892","https://openalex.org/W4383059188","https://openalex.org/W4385879793"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Spatial":[0],"memory":[1,72,89],"supported":[2],"by":[3,86,151],"the":[4,28,40,44,51,64,67,109,112,116,125,134,145,152,169,181],"hippocampus":[5],"is":[6],"a":[7,56,59,92,165],"critical":[8],"cognitive":[9],"function":[10],"in":[11,156],"daily":[12],"life.":[13],"It":[14],"helps":[15],"us":[16],"to":[17,19,43,58],"navigate":[18],"salient":[20],"goal":[21,94,114],"locations.":[22],"Hippocampal":[23],"place":[24,99,129,138,161,175],"cells":[25,33,100,162,176],"stably":[26],"represent":[27],"spatial":[29,71,117,149],"location,":[30],"while":[31,131,171],"c-Fos-expressing":[32],"(engram":[34],"cells)":[35],"contain":[36],"rich":[37],"information":[38],"about":[39],"environment,":[41],"contributing":[42],"encoding":[45,90],"and":[46],"retrieving":[47],"of":[48,53,63,69,91,98,147,168,180],"memories.":[49],"However,":[50],"role":[52],"cFos":[54],"as":[55],"gateway":[57],"more":[60],"profound":[61],"comprehension":[62],"mechanisms":[65],"underlying":[66],"process":[68],"goal-oriented":[70,148],"remained":[73,122],"poorly":[74],"understood.":[75],"In":[76],"this":[77],"study,":[78],"we":[79],"labeled":[80],"rats\u2019":[81],"c-Fos<sup":[82,126,135,172],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[83,127,136,159,173],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">+</sup>":[84,137,174],"neurons":[85],"Channelrhodopsin-2":[87],"during":[88],"specific":[93],"location.":[95],"A":[96],"subset":[97],"whether":[101],"they":[102],"expressed":[103],"c-Fos":[104],"was":[105],"identified":[106],"optogenetically.":[107],"As":[108],"rats":[110],"learned":[111],"new":[113],"locations,":[115,170],"correlation":[118],"between":[119],"task":[120],"periods":[121],"stable":[123,166],"for":[124,133],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">-</sup>":[128,160],"cell,":[130],"increased":[132],"cell.":[139],"This":[140],"finding":[141],"shed":[142],"light":[143],"on":[144],"processing":[146],"memories":[150],"hippocampal":[153],"network":[154],"involved":[155],"c-Fos.":[157],"C-Fos<sup":[158],"consistently":[163],"maintained":[164],"representation":[167],"exhibited":[177],"significant":[178],"flexibility":[179],"goal.":[182]},"counts_by_year":[],"updated_date":"2026-07-17T09:13:05.818461","created_date":"2025-10-10T00:00:00"}
