{"id":"https://openalex.org/W4294975697","doi":"https://doi.org/10.1109/embc48229.2022.9871901","title":"Why Reduced Inspiratory Pressure Could Determine Success of Non-Invasive Ventilation in Acute Hypoxic Respiratory Failure","display_name":"Why Reduced Inspiratory Pressure Could Determine Success of Non-Invasive Ventilation in Acute Hypoxic Respiratory Failure","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4294975697","doi":"https://doi.org/10.1109/embc48229.2022.9871901","pmid":"https://pubmed.ncbi.nlm.nih.gov/36085857"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871901","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871901","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102888488","display_name":"Liam Weaver","orcid":"https://orcid.org/0009-0007-2556-9382"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Liam Weaver","raw_affiliation_strings":["School of Engineering, University of Warwick,UK,CV4 7AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering, University of Warwick,UK,CV4 7AL","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039588793","display_name":"Sina Saffaran","orcid":"https://orcid.org/0000-0001-9296-180X"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sina Saffaran","raw_affiliation_strings":["School of Medicine, University of Nottingham,UK,NG7 2RD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Nottingham,UK,NG7 2RD","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000366861","display_name":"Marc Chikhani","orcid":"https://orcid.org/0000-0002-6449-8317"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marc Chikhani","raw_affiliation_strings":["University College London,Faculty of Engineering Science,UK,WC1E 6BT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London,Faculty of Engineering Science,UK,WC1E 6BT","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091498476","display_name":"John G. Laffey","orcid":"https://orcid.org/0000-0002-1246-9573"},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"John G. Laffey","raw_affiliation_strings":["School of Medicine, NUI Galway,Department of Anaesthesia and Intensive Care Medicine,Ireland","Department of Anaesthesia and Intensive Care Medicine, School of Medicine, NUI Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, NUI Galway,Department of Anaesthesia and Intensive Care Medicine,Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"Department of Anaesthesia and Intensive Care Medicine, School of Medicine, NUI Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064476507","display_name":"Tim E. Scott","orcid":null},"institutions":[{"id":"https://openalex.org/I2800655636","display_name":"Royal Navy","ror":"https://ror.org/003r53j91","country_code":"GB","type":"government","lineage":["https://openalex.org/I2800655636"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tim E. Scott","raw_affiliation_strings":["Royal Centre for Defence Medicine, ICT Centre,Academic Department of Military Anaesthesia and Critical Care,Birmingham,UK,B15 2SQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Centre for Defence Medicine, ICT Centre,Academic Department of Military Anaesthesia and Critical Care,Birmingham,UK,B15 2SQ","institution_ids":["https://openalex.org/I2800655636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029061731","display_name":"Luigi Camporota","orcid":"https://orcid.org/0000-0001-5600-1676"},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Luigi Camporota","raw_affiliation_strings":["Guy&#x0027;s and St Thomas&#x0027; NHS Foundation Trust,Department of Critical Care,London,UK,SE1 7EH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy&#x0027;s and St Thomas&#x0027; NHS Foundation Trust,Department of Critical Care,London,UK,SE1 7EH","institution_ids":["https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035273460","display_name":"Jonathan G. Hardman","orcid":"https://orcid.org/0000-0002-8959-8058"},"institutions":[{"id":"https://openalex.org/I1334287468","display_name":"Nottingham University Hospitals NHS Trust","ror":"https://ror.org/05y3qh794","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan G. Hardman","raw_affiliation_strings":["Nottingham University Hospitals NHS Trust,Nottingham,UK,NG7 2UH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nottingham University Hospitals NHS Trust,Nottingham,UK,NG7 2UH","institution_ids":["https://openalex.org/I1334287468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077819322","display_name":"Declan G. Bates","orcid":"https://orcid.org/0000-0003-1395-9846"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Declan G. Bates","raw_affiliation_strings":["School of Engineering, University of Warwick,UK,CV4 7AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering, University of Warwick,UK,CV4 7AL","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14935464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2022","issue":null,"first_page":"3265","last_page":"3268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7150108218193054},{"id":"https://openalex.org/keywords/ventilation","display_name":"Ventilation (architecture)","score":0.6362034678459167},{"id":"https://openalex.org/keywords/transpulmonary-pressure","display_name":"Transpulmonary pressure","score":0.6305903196334839},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.494505375623703},{"id":"https://openalex.org/keywords/pressure-support-ventilation","display_name":"Pressure support ventilation","score":0.4847714304924011},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"Respiratory failure","score":0.4676273465156555},{"id":"https://openalex.org/keywords/respiratory-system","display_name":"Respiratory system","score":0.4645417034626007},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"Mechanical ventilation","score":0.46233293414115906},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.34268367290496826},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.3312562108039856},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26861339807510376},{"id":"https://openalex.org/keywords/lung-volumes","display_name":"Lung volumes","score":0.23164242506027222}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7150108218193054},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.6362034678459167},{"id":"https://openalex.org/C2777421782","wikidata":"https://www.wikidata.org/wiki/Q7835341","display_name":"Transpulmonary pressure","level":4,"score":0.6305903196334839},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.494505375623703},{"id":"https://openalex.org/C2780368197","wikidata":"https://www.wikidata.org/wiki/Q7241738","display_name":"Pressure support ventilation","level":3,"score":0.4847714304924011},{"id":"https://openalex.org/C2776888751","wikidata":"https://www.wikidata.org/wiki/Q767485","display_name":"Respiratory failure","level":2,"score":0.4676273465156555},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4645417034626007},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.46233293414115906},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.34268367290496826},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3312562108039856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26861339807510376},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.23164242506027222},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063087","descriptor_name":"Noninvasive Ventilation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063087","descriptor_name":"Noninvasive Ventilation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063087","descriptor_name":"Noninvasive Ventilation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc48229.2022.9871901","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871901","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36085857","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36085857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:wrap.warwick.ac.uk:169332","is_oa":false,"landing_page_url":"https://wrap.warwick.ac.uk/169332/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Item"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7799999713897705,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2065071641","display_name":"Investigating Strategies for Mechanical Ventilation in COVID-19 via Computational Simulation of Virtual Patients","funder_award_id":"EP/V014455/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5099180843","display_name":null,"funder_award_id":"EP/P023444/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5883964741","display_name":"Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit: Realising Industrial and Medical Applications","funder_award_id":"EP/P023444/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1938806933","https://openalex.org/W2013033345","https://openalex.org/W2026209216","https://openalex.org/W2035271293","https://openalex.org/W2053066034","https://openalex.org/W2057489267","https://openalex.org/W2059818497","https://openalex.org/W2072378922","https://openalex.org/W2114262384","https://openalex.org/W2129289400","https://openalex.org/W2137731976","https://openalex.org/W2237044322","https://openalex.org/W2331306740","https://openalex.org/W2541706955","https://openalex.org/W3020183443","https://openalex.org/W3178592321"],"related_works":["https://openalex.org/W2382907023","https://openalex.org/W2356112316","https://openalex.org/W2350261372","https://openalex.org/W2348840217","https://openalex.org/W75506111","https://openalex.org/W2035271293","https://openalex.org/W2353667050","https://openalex.org/W2377301629","https://openalex.org/W3032753761","https://openalex.org/W2035139741"],"abstract_inverted_index":{"The":[0],"magnitude":[1],"of":[2,11,33,42,66,83,97,105,111,127,139],"inspiratory":[3,61,101,123],"effort":[4,62],"relief":[5],"within":[6],"the":[7,40,54,81,95],"first":[8],"2":[9],"hours":[10],"non-invasive":[12,43,112],"ventilation":[13,44,129],"for":[14,147],"hypoxic":[15],"respiratory":[16],"failure":[17],"was":[18],"shown":[19],"in":[20,56,60,100,135],"a":[21,143],"recent":[22,148],"exploratory":[23],"clinical":[24,51,149],"study":[25],"to":[26,45,64],"be":[27],"an":[28],"early":[29],"and":[30,50,90],"accurate":[31],"predictor":[32],"outcome":[34],"at":[35],"24":[36],"hours.":[37],"We":[38,116],"simulated":[39],"application":[41,110,126],"three":[46],"patients":[47],"whose":[48],"physiological":[49,145],"characteristics":[52],"match":[53],"data":[55],"that":[57,121],"study.":[58],"Reductions":[59],"corresponding":[63],"reductions":[65,99,134],"esophageal":[67],"pressure":[68,92,124],"swing":[69],"greater":[70],"than":[71,79],"10":[72],"cmH":[73],"<inf":[74],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[75],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</inf>":[76],"O":[77],"more":[78],"halved":[80],"values":[82],"total":[84],"lung":[85,106,140],"stress,":[86],"driving":[87],"pressure,":[88,102],"power":[89],"transpulmonary":[91],"swing.":[93],"In":[94],"absence":[96],"significant":[98],"multiple":[103,136],"indicators":[104,138],"injury":[107],"increased":[108],"after":[109,125],"ventilation.":[113],"Clinical":[114],"Relevance-":[115],"show":[117],"using":[118],"computer":[119],"simulation":[120],"reduced":[122],"noninvasive":[128],"translates":[130],"directly":[131],"into":[132],"large":[133],"well-established":[137],"injury,":[141],"providing":[142],"potential":[144],"explanation":[146],"findings.":[150]},"counts_by_year":[],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}