{"id":"https://openalex.org/W4295455964","doi":"https://doi.org/10.1109/embc48229.2022.9871558","title":"CETSA Feature Based Clustering for Protein Outlier Discovery by Protein-to-Protein Interaction Prediction","display_name":"CETSA Feature Based Clustering for Protein Outlier Discovery by Protein-to-Protein Interaction Prediction","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4295455964","doi":"https://doi.org/10.1109/embc48229.2022.9871558","pmid":"https://pubmed.ncbi.nlm.nih.gov/36085889"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871558","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871558","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104272403","display_name":"Xulei Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I3005327000","display_name":"Institute for Infocomm Research","ror":"https://ror.org/053rfa017","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3005327000","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xulei Yang","raw_affiliation_strings":["Institute for Infocomm Research (I2R), Agency for Science, Technology and Research,Singapore","Institute for Infocomm Research (I2R), Agency for Science, Technology and Research, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Infocomm Research (I2R), Agency for Science, Technology and Research,Singapore","institution_ids":["https://openalex.org/I3005327000"]},{"raw_affiliation_string":"Institute for Infocomm Research (I2R), Agency for Science, Technology and Research, Singapore","institution_ids":["https://openalex.org/I3005327000","https://openalex.org/I115228651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014326296","display_name":"Qing Da","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Qing Da","raw_affiliation_strings":["National University of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018528574","display_name":"Peisheng Qian","orcid":null},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I3005327000","display_name":"Institute for Infocomm Research","ror":"https://ror.org/053rfa017","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3005327000","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Peisheng Qian","raw_affiliation_strings":["Institute for Infocomm Research (I2R), Agency for Science, Technology and Research,Singapore","Institute for Infocomm Research (I2R), Agency for Science, Technology and Research, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Infocomm Research (I2R), Agency for Science, Technology and Research,Singapore","institution_ids":["https://openalex.org/I3005327000"]},{"raw_affiliation_string":"Institute for Infocomm Research (I2R), Agency for Science, Technology and Research, Singapore","institution_ids":["https://openalex.org/I3005327000","https://openalex.org/I115228651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070594442","display_name":"Bharadwaj Veeravalli","orcid":"https://orcid.org/0000-0001-9000-1813"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Bharadwaj Veeravalli","raw_affiliation_strings":["National University of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tam Wai Leong","orcid":null},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210103786","display_name":"National University Cancer Institute, Singapore","ror":"https://ror.org/025yypj46","country_code":"SG","type":"education","lineage":["https://openalex.org/I4210103786","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Tam Wai Leong","raw_affiliation_strings":["Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)","Cancer Science Institute of Singapore, National University of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I66068411"]},{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore","institution_ids":["https://openalex.org/I4210103786","https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100648395","display_name":"Lingyun Dai","orcid":"https://orcid.org/0000-0001-9386-5967"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["CN","SG"],"is_corresponding":false,"raw_author_name":"Lingyun Dai","raw_affiliation_strings":["The First Affiliated Hospital of Southern University of Science and Technology,Shenzhen,China","Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore","The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Southern University of Science and Technology,Shenzhen,China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060431795","display_name":"P. Nordlund","orcid":"https://orcid.org/0000-0002-7794-702X"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210116966","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/02fsfnf94","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210116966","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["RU","SE","SG"],"is_corresponding":false,"raw_author_name":"Par Nordlund","raw_affiliation_strings":["Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR),Singapore","Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore","Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR),Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210116966"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026462288","display_name":"Nayana Prabhu","orcid":"https://orcid.org/0000-0002-2350-6552"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210116966","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/02fsfnf94","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210116966","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["RU","SG"],"is_corresponding":false,"raw_author_name":"Nayana Prabhu","raw_affiliation_strings":["Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR),Singapore","Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR),Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210116966"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050743199","display_name":"Ziyuan Zhao","orcid":"https://orcid.org/0000-0002-4403-825X"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I3005327000","display_name":"Institute for Infocomm Research","ror":"https://ror.org/053rfa017","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3005327000","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ziyuan Zhao","raw_affiliation_strings":["Institute for Infocomm Research (I2R), Agency for Science, Technology and Research,Singapore","Institute for Infocomm Research (I2R), Agency for Science, Technology and Research, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Infocomm Research (I2R), Agency for Science, Technology and Research,Singapore","institution_ids":["https://openalex.org/I3005327000"]},{"raw_affiliation_string":"Institute for Infocomm Research (I2R), Agency for Science, Technology and Research, Singapore","institution_ids":["https://openalex.org/I3005327000","https://openalex.org/I115228651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010092389","display_name":"Zeng Zeng","orcid":"https://orcid.org/0000-0002-2405-0323"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I3005327000","display_name":"Institute for Infocomm Research","ror":"https://ror.org/053rfa017","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3005327000","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Zeng Zeng","raw_affiliation_strings":["Institute for Infocomm Research (I2R), Agency for Science, Technology and Research,Singapore","Institute for Infocomm Research (I2R), Agency for Science, Technology and Research, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Infocomm Research (I2R), Agency for Science, Technology and Research,Singapore","institution_ids":["https://openalex.org/I3005327000"]},{"raw_affiliation_string":"Institute for Infocomm Research (I2R), Agency for Science, Technology and Research, Singapore","institution_ids":["https://openalex.org/I3005327000","https://openalex.org/I115228651"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5193,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55346939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2022","issue":null,"first_page":"1659","last_page":"1662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7094783186912537},{"id":"https://openalex.org/keywords/outlier","display_name":"Outlier","score":0.5873515009880066},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5531008243560791},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4964781403541565},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.45355847477912903},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.42478036880493164},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4049347937107086},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.38901373744010925}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7094783186912537},{"id":"https://openalex.org/C79337645","wikidata":"https://www.wikidata.org/wiki/Q779824","display_name":"Outlier","level":2,"score":0.5873515009880066},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5531008243560791},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4964781403541565},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.45355847477912903},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.42478036880493164},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4049347937107086},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.38901373744010925},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc48229.2022.9871558","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871558","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36085889","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36085889","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.41999998688697815}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1611787727","https://openalex.org/W1993251792","https://openalex.org/W2013787405","https://openalex.org/W2050526879","https://openalex.org/W2130832525","https://openalex.org/W2170835800","https://openalex.org/W2319422264","https://openalex.org/W2616561032","https://openalex.org/W2762422564","https://openalex.org/W2763081415","https://openalex.org/W2775249104","https://openalex.org/W2787587553","https://openalex.org/W2809890174","https://openalex.org/W3114249272","https://openalex.org/W3116040669"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W3183283580","https://openalex.org/W2337929971","https://openalex.org/W4313069709","https://openalex.org/W4283741549","https://openalex.org/W2546942002","https://openalex.org/W4250175685","https://openalex.org/W2970216048","https://openalex.org/W2382607599","https://openalex.org/W2360069064"],"abstract_inverted_index":{"The":[0],"Cellular":[1],"Thermal":[2],"Shift":[3],"Assay":[4],"(CETSA)":[5],"is":[6,165],"a":[7,77,108,166,186],"biophysical":[8],"assay":[9],"based":[10],"on":[11],"the":[12,47,65,96,102,119,130,136,141,173],"principle":[13],"of":[14,18,41,111,132,138,152,169],"ligand-induced":[15],"thermal":[16],"stabilization":[17],"target":[19,26],"proteins.":[20],"This":[21],"technology":[22],"has":[23,30,161],"revolutionized":[24],"cell-based":[25],"engagement":[27],"studies":[28],"and":[29,52,150],"been":[31,45,58],"used":[32,184],"as":[33,185],"guidance":[34],"for":[35,72,107,155,190],"drug":[36],"design.":[37],"Although":[38],"many":[39],"ap-plications":[40],"CETSA":[42,50,70,89,170,180],"data":[43,51,71,181,188],"have":[44,56,146],"explored,":[46],"correlations":[48],"between":[49],"protein-protein":[53],"interactions":[54],"(PPI)":[55],"barely":[57],"touched.":[59],"In":[60],"this":[61],"study,":[62],"we":[63,122],"conduct":[64],"first":[66],"exploration":[67,192],"study":[68,160],"applying":[69],"PPI":[73,85,98,104,115,164,191],"prediction.":[74],"We":[75],"use":[76,123],"machine":[78],"learning":[79],"method,":[80],"Decision":[81],"Tree,":[82],"to":[83,127],"predict":[84],"scores":[86,99],"using":[87],"proteins'":[88],"features.":[90],"It":[91],"shows":[92],"promising":[93],"results":[94],"that":[95,163,179],"predicted":[97],"closely":[100],"match":[101],"ground-truth":[103],"scores.":[105],"Furthermore,":[106],"small":[109],"number":[110,131],"protein":[112,143],"pairs,":[113],"whose":[114],"score":[116],"predictions":[117],"mismatch":[118],"ground":[120],"truth,":[121],"iterative":[124,139],"clustering":[125],"strategy":[126],"gradually":[128],"reduce":[129],"these":[133],"pairs.":[134],"At":[135,172],"end":[137],"clustering,":[140],"remaining":[142],"pairs":[144],"may":[145],"some":[147],"unusual":[148],"properties":[149],"are":[151],"scientific":[153],"value":[154],"further":[156],"biological":[157],"investigation.":[158],"Our":[159],"demonstrated":[162],"brand-new":[167],"application":[168],"data.":[171],"same":[174],"time,":[175],"it":[176],"also":[177],"manifests":[178],"can":[182],"be":[183],"new":[187],"source":[189],"study.":[193]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}