{"id":"https://openalex.org/W4295453551","doi":"https://doi.org/10.1109/embc48229.2022.9871551","title":"Low cardiac frequency associated with higher number of extrasistoles in a computational model of Brugada Syndrome","display_name":"Low cardiac frequency associated with higher number of extrasistoles in a computational model of Brugada Syndrome","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4295453551","doi":"https://doi.org/10.1109/embc48229.2022.9871551","pmid":"https://pubmed.ncbi.nlm.nih.gov/36086285"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871551","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871551","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11382/570075","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031543913","display_name":"Paolo Seghetti","orcid":"https://orcid.org/0000-0001-5965-6539"},"institutions":[{"id":"https://openalex.org/I4210118921","display_name":"Institute of Life Sciences","ror":"https://ror.org/02927dx12","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210118921","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]}],"countries":["IN","IT"],"is_corresponding":true,"raw_author_name":"Paolo Seghetti","raw_affiliation_strings":["Institute of Life Sciences,Sant&#x0027;Anna","Institute of Clinical Physiology, National Research Council, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Institute of Life Sciences,Sant&#x0027;Anna","institution_ids":["https://openalex.org/I4210118921"]},{"raw_affiliation_string":"Institute of Clinical Physiology, National Research Council, Pisa, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4210106076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045138156","display_name":"Niccol\u00f2 Biasi","orcid":"https://orcid.org/0000-0001-8194-1010"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Niccolo Biasi","raw_affiliation_strings":["University of Pisa,Information Engineering Department,Pisa,Italy","Information Engineering Department, University of Pisa, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"University of Pisa,Information Engineering Department,Pisa,Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Information Engineering Department, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015494107","display_name":"Marco Laurino","orcid":"https://orcid.org/0000-0003-4798-5196"},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Laurino","raw_affiliation_strings":["Institute of Clinical Physiology, National Research Council,Pisa,Italy","Institute of Clinical Physiology, National Research Council, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Institute of Clinical Physiology, National Research Council,Pisa,Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4210106076"]},{"raw_affiliation_string":"Institute of Clinical Physiology, National Research Council, Pisa, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4210106076"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066692839","display_name":"Alessandro Tognetti","orcid":"https://orcid.org/0000-0001-9848-4071"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I1300504238","display_name":"Piaggio (Italy)","ror":"https://ror.org/00r254y42","country_code":"IT","type":"company","lineage":["https://openalex.org/I1300504238"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Tognetti","raw_affiliation_strings":["University of Pisa,Information Engineering Department,Pisa,Italy","Information Engineering Department, University of Pisa, Pisa, Italy","Research Center \"E.Piaggio\", University of Pisa, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"University of Pisa,Information Engineering Department,Pisa,Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Information Engineering Department, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Research Center \"E.Piaggio\", University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I1300504238","https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5031543913"],"corresponding_institution_ids":["https://openalex.org/I4210106076","https://openalex.org/I4210118921","https://openalex.org/I4210155236"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16047297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"253","issue":null,"first_page":"2262","last_page":"2265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9815999865531921,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.9764999747276306,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brugada-syndrome","display_name":"Brugada syndrome","score":0.9260261654853821},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"Ventricular fibrillation","score":0.8029083013534546},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.7443583011627197},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.743331253528595},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6101701855659485},{"id":"https://openalex.org/keywords/fibrillation","display_name":"Fibrillation","score":0.4723188579082489},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"Cardiac arrhythmia","score":0.4133906662464142},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"Electrocardiography","score":0.4128260314464569},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.2841663360595703}],"concepts":[{"id":"https://openalex.org/C2777382798","wikidata":"https://www.wikidata.org/wiki/Q599683","display_name":"Brugada syndrome","level":2,"score":0.9260261654853821},{"id":"https://openalex.org/C2781005686","wikidata":"https://www.wikidata.org/wiki/Q848662","display_name":"Ventricular fibrillation","level":2,"score":0.8029083013534546},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7443583011627197},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.743331253528595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6101701855659485},{"id":"https://openalex.org/C2777356233","wikidata":"https://www.wikidata.org/wiki/Q1001150","display_name":"Fibrillation","level":3,"score":0.4723188579082489},{"id":"https://openalex.org/C2988455589","wikidata":"https://www.wikidata.org/wiki/Q189331","display_name":"Cardiac arrhythmia","level":3,"score":0.4133906662464142},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.4128260314464569},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.2841663360595703}],"mesh":[{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053840","descriptor_name":"Brugada Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D053840","descriptor_name":"Brugada Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D053840","descriptor_name":"Brugada Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D053840","descriptor_name":"Brugada Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D053840","descriptor_name":"Brugada Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D053840","descriptor_name":"Brugada Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1109/embc48229.2022.9871551","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871551","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36086285","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36086285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:arpi.unipi.it:11568/1151862","is_oa":false,"landing_page_url":"https://hdl.handle.net/11568/1151862","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:it.cnr:prodotti:474863","is_oa":false,"landing_page_url":"http://www.cnr.it/prodotto/i/474863","pdf_url":null,"source":{"id":"https://openalex.org/S7407055101","display_name":"CNR ExploRA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"info:cnr-pdr/source/autori:Paolo Seghetti, Niccolo Biasi, Marco Laurino, Alessandro Tognetti/congresso_nome:2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)/congresso_luogo:/congresso_data:11-15 July 2022/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:","raw_type":"Contributo in atti di convegno"},{"id":"pmh:oai:www.iris.sssup.it:11382/570075","is_oa":true,"landing_page_url":"https://hdl.handle.net/11382/570075","pdf_url":null,"source":{"id":"https://openalex.org/S4377196376","display_name":"CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I162290304","host_organization_name":"Scuola Superiore Sant'Anna","host_organization_lineage":["https://openalex.org/I162290304"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:www.iris.sssup.it:11382/570075","is_oa":true,"landing_page_url":"https://hdl.handle.net/11382/570075","pdf_url":null,"source":{"id":"https://openalex.org/S4377196376","display_name":"CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I162290304","host_organization_name":"Scuola Superiore Sant'Anna","host_organization_lineage":["https://openalex.org/I162290304"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317295","display_name":"Dipartimenti di Eccellenza","ror":null},{"id":"https://openalex.org/F4320324499","display_name":"Universit\u00e0 di Pisa","ror":"https://ror.org/03ad39j10"},{"id":"https://openalex.org/F4320331528","display_name":"Ministero dell'Universit\u00e0 e della Ricerca","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W220488953","https://openalex.org/W1874320426","https://openalex.org/W1969239041","https://openalex.org/W1981872906","https://openalex.org/W1992733056","https://openalex.org/W1996829258","https://openalex.org/W2095484056","https://openalex.org/W2113243306","https://openalex.org/W2114516874","https://openalex.org/W2130139165","https://openalex.org/W2136071898","https://openalex.org/W2148023358","https://openalex.org/W2151232306","https://openalex.org/W2539080347","https://openalex.org/W2596328064","https://openalex.org/W2616249537","https://openalex.org/W2767767978","https://openalex.org/W3001756357","https://openalex.org/W3088763441","https://openalex.org/W3210159958","https://openalex.org/W6774990696"],"related_works":["https://openalex.org/W1996829258","https://openalex.org/W2992882273","https://openalex.org/W2099963082","https://openalex.org/W1984029483","https://openalex.org/W2789937767","https://openalex.org/W3125179740","https://openalex.org/W2072079788","https://openalex.org/W600729162","https://openalex.org/W2110884637","https://openalex.org/W641465021"],"abstract_inverted_index":{"Brugada":[0],"Syndrome":[1],"is":[2,12,20],"a":[3,40,67],"form":[4],"of":[5,48,60,72],"idiopathic":[6],"ventricular":[7,18],"fibrillation,":[8],"to":[9,44],"date":[10],"there":[11],"no":[13],"definitive":[14],"theory":[15],"about":[16],"how":[17],"fibrillation":[19],"initiated":[21],"or":[22],"its":[23],"substrate.":[24],"Starting":[25],"from":[26],"the":[27,46,58,70],"clinical":[28],"observation":[29],"that":[30,57],"cardiac":[31,49,64,73],"episodes":[32],"are":[33],"more":[34],"frequent":[35],"at":[36],"rest,":[37],"we":[38],"developed":[39],"model":[41],"in":[42,69],"order":[43],"study":[45],"effect":[47],"frequency":[50,65],"on":[51],"reentrant":[52],"activity.":[53],"Our":[54],"results":[55],"suggest":[56],"combination":[59],"arrhythmic":[61],"substrate":[62],"and":[63],"has":[66],"role":[68],"insurgence":[71],"arrhythmia.":[74]},"counts_by_year":[],"updated_date":"2026-03-02T08:37:19.008085","created_date":"2025-10-10T00:00:00"}
