{"id":"https://openalex.org/W4295422446","doi":"https://doi.org/10.1109/embc48229.2022.9871508","title":"Synthesis and Characterization of a new Alginate-Gelatine Aerogel for Tissue Engineering","display_name":"Synthesis and Characterization of a new Alginate-Gelatine Aerogel for Tissue Engineering","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4295422446","doi":"https://doi.org/10.1109/embc48229.2022.9871508","pmid":"https://pubmed.ncbi.nlm.nih.gov/36086473"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871508","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871508","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074697996","display_name":"Immacolata Greco","orcid":"https://orcid.org/0009-0009-7471-7032"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Immacolata Greco","raw_affiliation_strings":["microgravity research center of Universit&#x00E9; Libre de Bruxelles,Bruxelles,Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"microgravity research center of Universit&#x00E9; Libre de Bruxelles,Bruxelles,Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048675936","display_name":"Carolina Varon","orcid":"https://orcid.org/0000-0002-9581-0676"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Carolina Varon","raw_affiliation_strings":["microgravity research center of Universit&#x00E9; Libre de Bruxelles,Bruxelles,Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"microgravity research center of Universit&#x00E9; Libre de Bruxelles,Bruxelles,Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041824534","display_name":"Carlo Saverio Iorio","orcid":"https://orcid.org/0000-0003-0952-0064"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Carlo S. Iorio","raw_affiliation_strings":["microgravity research center of Universit&#x00E9; Libre de Bruxelles,Bruxelles,Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"microgravity research center of Universit&#x00E9; Libre de Bruxelles,Bruxelles,Belgium","institution_ids":["https://openalex.org/I132053463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I132053463"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2022","issue":null,"first_page":"3915","last_page":"3918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12195","display_name":"Aerogels and thermal insulation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12195","display_name":"Aerogels and thermal insulation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10338","display_name":"Advanced Sensor and Energy Harvesting Materials","score":0.9811000227928162,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10313","display_name":"Surface Modification and Superhydrophobicity","score":0.9372000098228455,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aerogel","display_name":"Aerogel","score":0.7283554077148438},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.6849725842475891},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.6141350269317627},{"id":"https://openalex.org/keywords/self-healing-hydrogels","display_name":"Self-healing hydrogels","score":0.5927978157997131},{"id":"https://openalex.org/keywords/scaffold","display_name":"Scaffold","score":0.5307885408401489},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5151447057723999},{"id":"https://openalex.org/keywords/adhesion","display_name":"Adhesion","score":0.5002779960632324},{"id":"https://openalex.org/keywords/porosity","display_name":"Porosity","score":0.48941341042518616},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"Cell adhesion","score":0.4560629427433014},{"id":"https://openalex.org/keywords/chemical-engineering","display_name":"Chemical engineering","score":0.42287886142730713},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.41138312220573425},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.29390060901641846},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.28514915704727173},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.261260062456131},{"id":"https://openalex.org/keywords/polymer-chemistry","display_name":"Polymer chemistry","score":0.24917113780975342},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10023865103721619}],"concepts":[{"id":"https://openalex.org/C2780012831","wikidata":"https://www.wikidata.org/wiki/Q381490","display_name":"Aerogel","level":2,"score":0.7283554077148438},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.6849725842475891},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6141350269317627},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.5927978157997131},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.5307885408401489},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5151447057723999},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5002779960632324},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.48941341042518616},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4560629427433014},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.42287886142730713},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.41138312220573425},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29390060901641846},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28514915704727173},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.261260062456131},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.24917113780975342},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10023865103721619},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc48229.2022.9871508","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871508","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36086473","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36086473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1514165635","https://openalex.org/W1851070377","https://openalex.org/W2000449739","https://openalex.org/W2042079661","https://openalex.org/W2044876907","https://openalex.org/W2047305537","https://openalex.org/W2051194659","https://openalex.org/W2090621459","https://openalex.org/W2094186006","https://openalex.org/W2095675381","https://openalex.org/W2153290574","https://openalex.org/W2156525630","https://openalex.org/W2414545839","https://openalex.org/W2913205283","https://openalex.org/W2974933784","https://openalex.org/W3007530783","https://openalex.org/W3047024864","https://openalex.org/W3143321472"],"related_works":["https://openalex.org/W2809376314","https://openalex.org/W1966288407","https://openalex.org/W1458672946","https://openalex.org/W3003069570","https://openalex.org/W2412922490","https://openalex.org/W2626164717","https://openalex.org/W2387757681","https://openalex.org/W2478420051","https://openalex.org/W3196863326","https://openalex.org/W922543731"],"abstract_inverted_index":{"Scaffolds":[0],"have":[1],"been":[2],"used":[3,44],"to":[4,45,60],"stimulate":[5],"cell":[6,8,11,34,139],"migration,":[7],"adhesion,":[9],"and":[10,55,122,141,159],"proliferation":[12],"as":[13,156],"extracellular":[14],"matrix":[15],"analogues.":[16],"This":[17],"study":[18],"proposes":[19],"a":[20,58,88,116],"novel":[21],"method":[22],"for":[23,33,67,137,152],"creating":[24],"hybrid":[25],"alginate-gelatine":[26,39,147],"aerogel-based":[27],"scaffold,":[28],"which":[29,49],"could":[30],"be":[31,76],"suitable":[32,150],"adhesion.":[35],"To":[36],"this":[37,86],"end,":[38],"at":[40,53],"4%":[41],"was":[42,97],"first":[43],"make":[46],"stable":[47],"hydrogels,":[48],"were":[50],"then":[51],"frozen":[52],"-70\u00b0C":[54],"dried":[56],"under":[57],"vacuum":[59],"produced":[61],"aerogels.":[62],"Aerogels":[63],"are":[64,149],"materials":[65],"known":[66],"their":[68],"extremely":[69],"low":[70],"density,":[71],"which,":[72],"by":[73],"definition,":[74],"should":[75],"lower":[77],"than":[78],"0.5":[79],"g/cm":[80,93],"<sup":[81,94],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[82,95],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">3</sup>":[83,96],",":[84],"In":[85,111],"study,":[87],"bulk":[89],"density":[90],"of":[91,108,129],"0.16":[92],"reached,":[98],"confirming":[99],"that":[100,144],"the":[101,106,113,135,145],"created":[102],"material":[103,114],"fits":[104],"within":[105,134],"definition":[107],"an":[109,125],"aerogel.":[110],"addition,":[112],"presented":[115],"sponge-like":[117],"structure,":[118],"high":[119],"absorption":[120],"properties,":[121],"high-porosity,":[123],"with":[124],"average":[126],"pore":[127],"size":[128],"193\u03bcm.":[130],"These":[131],"properties":[132],"fit":[133],"requirements":[136],"fibroblast":[138],"infiltrate":[140],"survival,":[142],"demonstrating":[143],"proposed":[146],"aerogels":[148],"candidates":[151],"various":[153],"applications":[154],"such":[155],"tissue":[157],"engineering":[158],"regenerative":[160],"medicine.":[161]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}