{"id":"https://openalex.org/W4294975490","doi":"https://doi.org/10.1109/embc48229.2022.9871454","title":"Effect of Graded Targeted Temperature Management on Cerebral Glucose Spatiotemporal Characteristics after Cardiac Arrest","display_name":"Effect of Graded Targeted Temperature Management on Cerebral Glucose Spatiotemporal Characteristics after Cardiac Arrest","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4294975490","doi":"https://doi.org/10.1109/embc48229.2022.9871454","pmid":"https://pubmed.ncbi.nlm.nih.gov/36086320"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871454","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871454","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9639334","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100741929","display_name":"Zhuoran Wang","orcid":"https://orcid.org/0000-0001-5175-8645"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuoran Wang","raw_affiliation_strings":["University of Maryland, School of Medicine,Department of Neurosurgery, Department of Diagnostic Radiology and Nuclear Medicine,Baltimore,MD,USA,21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, School of Medicine,Department of Neurosurgery, Department of Diagnostic Radiology and Nuclear Medicine,Baltimore,MD,USA,21201","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065601005","display_name":"Songyu Chen","orcid":"https://orcid.org/0000-0001-5748-0314"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Songyu Chen","raw_affiliation_strings":["University of Maryland, School of Medicine,Department of Neurosurgery, Department of Diagnostic Radiology and Nuclear Medicine,Baltimore,MD,USA,21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, School of Medicine,Department of Neurosurgery, Department of Diagnostic Radiology and Nuclear Medicine,Baltimore,MD,USA,21201","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000533473","display_name":"Mark F. Smith","orcid":null},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark F. Smith","raw_affiliation_strings":["University of Maryland, School of Medicine,Department of Neurosurgery, Department of Diagnostic Radiology and Nuclear Medicine,Baltimore,MD,USA,21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, School of Medicine,Department of Neurosurgery, Department of Diagnostic Radiology and Nuclear Medicine,Baltimore,MD,USA,21201","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100612505","display_name":"Xiaofeng Jia","orcid":"https://orcid.org/0000-0003-1445-8525"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Jia","raw_affiliation_strings":["University of Maryland, School of Medicine,Anatomy Neurobiology, Orthopaedics,Department of Neurosurgery,Baltimore,MD,USA,21201","Department of Biomedical Engineering, Anesthesiology and Critical Care Medicine Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, School of Medicine,Anatomy Neurobiology, Orthopaedics,Department of Neurosurgery,Baltimore,MD,USA,21201","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Anesthesiology and Critical Care Medicine Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.196875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2022","issue":null,"first_page":"182","last_page":"185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3568168878555298},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3269995152950287},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.28868168592453003},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2883792221546173}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3568168878555298},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3269995152950287},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28868168592453003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2883792221546173}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001237","descriptor_name":"Asphyxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001237","descriptor_name":"Asphyxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001237","descriptor_name":"Asphyxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc48229.2022.9871454","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871454","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36086320","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36086320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9639334","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9639334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annu Int Conf IEEE Eng Med Biol Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9639334","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9639334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annu Int Conf IEEE Eng Med Biol Soc","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6200000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G149273551","display_name":null,"funder_award_id":"UL1-TR003098","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G1588971552","display_name":null,"funder_award_id":"R01HL118084","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2236029305","display_name":null,"funder_award_id":"R01NS117102","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4760970569","display_name":null,"funder_award_id":"R01 NS110387","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W92640518","https://openalex.org/W1966573493","https://openalex.org/W1987570599","https://openalex.org/W2038811384","https://openalex.org/W2050917505","https://openalex.org/W2058056440","https://openalex.org/W2074706974","https://openalex.org/W2120561852","https://openalex.org/W2259205596","https://openalex.org/W2419165202","https://openalex.org/W2752605669","https://openalex.org/W2788295856","https://openalex.org/W2791453970","https://openalex.org/W2796279370","https://openalex.org/W2811295475","https://openalex.org/W2980367240","https://openalex.org/W2999465467","https://openalex.org/W3044716128","https://openalex.org/W3097956594","https://openalex.org/W3120442053","https://openalex.org/W3122179404"],"related_works":["https://openalex.org/W3188962172","https://openalex.org/W2772917594","https://openalex.org/W4306742369","https://openalex.org/W4303457083","https://openalex.org/W2131146434","https://openalex.org/W2951359407","https://openalex.org/W4376623224","https://openalex.org/W3136979370","https://openalex.org/W4387849428","https://openalex.org/W2058170566"],"abstract_inverted_index":{"Cardiac":[0],"arrest":[1],"(CA)":[2],"is":[3,19,33],"a":[4,46,111],"fatal":[5],"disease":[6],"with":[7,23,45,121,173],"high":[8],"rates":[9],"of":[10,39,48,72,97,126,133,169],"neurological":[11,105,175],"impairment.":[12],"At":[13],"present,":[14],"targeted":[15],"temperature":[16],"management":[17],"(TTM)":[18],"the":[20,37,104,149,166],"only":[21],"strategy":[22],"firm":[24],"clinical":[25],"evidence":[26],"to":[27,58,91],"prove":[28],"its":[29,43],"effectiveness.":[30],"However,":[31],"there":[32],"still":[34],"controversy":[35],"on":[36,42],"implementation":[38],"TTM,":[40],"particularly":[41],"depth,":[44],"lack":[47],"elucidated":[49],"underlying":[50],"therapeutic":[51],"mechanisms.":[52],"Six":[53],"Wistar":[54],"rats":[55],"were":[56,78,155],"subjected":[57],"8":[59],"min":[60],"asphyxia-CA":[61],"and":[62,95,151],"randomly":[63],"divided":[64],"into":[65],"TTM":[66],"at$33^{\\mathrm{o}}\\mathrm{C}(\\mathrm{n}=3)$or$35^\\circ":[67],"\\mathrm{C}$groups$(\\mathrm{n}=3)$.":[68],"The":[69],"spatiotemporal":[70,167],"characteristics":[71,168],"cerebral":[73],"glucose":[74,171],"metabolism":[75,125],"after":[76,136],"CA":[77],"investigated":[79],"by":[80,117],"18F-FDG":[81],"microPET/CT.":[82],"Myelin":[83],"Basic":[84],"Protein":[85],"(MBP)":[86],"immunofluorescence":[87],"staining":[88],"was":[89,101,110,129],"used":[90],"assess":[92],"acute":[93],"injury":[94],"recovery":[96,100,116],"oligodendrocytes.":[98],"Functional":[99],"evaluated":[102],"using":[103],"deficit":[106],"score":[107],"(NDS).":[108],"There":[109],"significant":[112],"improvement":[113],"in":[114,148,153,158],"functional":[115],"NDS":[118],"(p$33^{\\mathrm{o}}\\mathrm{C}$group":[119],"compared":[120,162],"the$35^\\circ":[122],"\\mathrm{C}$group.":[123],"Glucose":[124],"the$33^\\circ":[127],"\\mathrm{C}$group":[128],"higher":[130],"than":[131,157],"that":[132,144],"the$35^{\\mathrm{o}}\\mathrm{C}$group":[134],"early":[135],"resuscitation":[137],"(within":[138],"10":[139],"minutes).":[140],"Immunofluorescence":[141],"analysis":[142],"showed":[143],"positive":[145],"MBP":[146],"signals":[147],"cortex":[150],"hippocampus":[152],"the$33^{\\mathrm{o}}\\mathrm{C}$group":[154],"greater":[156],"the$35^{\\mathrm{o}}\\mathrm{C}$group.":[159],"In":[160],"conclusion,":[161],"to$35^{\\mathrm{o}}\\mathrm{C}$TTM,$33^\\circ":[163],"\\mathrm{C}$TTM":[164],"changed":[165],"brain":[170],"metabolisms":[172],"improved":[174],"function,":[176],"which":[177],"may":[178],"be":[179],"through":[180],"oligodendrocyte":[181],"participation.":[182]},"counts_by_year":[],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
