{"id":"https://openalex.org/W4294975154","doi":"https://doi.org/10.1109/embc48229.2022.9871251","title":"A Graph Based Neural Network Approach to Immune Profiling of Multiplexed Tissue Samples","display_name":"A Graph Based Neural Network Approach to Immune Profiling of Multiplexed Tissue Samples","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4294975154","doi":"https://doi.org/10.1109/embc48229.2022.9871251","pmid":"https://pubmed.ncbi.nlm.nih.gov/36085678"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871251","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871251","pdf_url":"https://ieeexplore.ieee.org/ielx7/9870821/9870822/09871251.pdf","source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ieeexplore.ieee.org/ielx7/9870821/9870822/09871251.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040225784","display_name":"Natalia Garcia-Martin","orcid":"https://orcid.org/0000-0002-5457-251X"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Natalia Garcia Martin","raw_affiliation_strings":["Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","Department of Statistics, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","institution_ids":["https://openalex.org/I4210142469","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Statistics, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082807892","display_name":"Stefano Malacrino","orcid":"https://orcid.org/0000-0003-1237-8572"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stefano Malacrino","raw_affiliation_strings":["Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK","Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","institution_ids":["https://openalex.org/I4210142469","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063002856","display_name":"Marta Wojciechowska","orcid":"https://orcid.org/0000-0002-9561-8799"},"institutions":[{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marta Wojciechowska","raw_affiliation_strings":["Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","Department of Engineering Sci-ence, Institute of Biomedical Engineering, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","institution_ids":["https://openalex.org/I4210142469","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Engineering Sci-ence, Institute of Biomedical Engineering, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112231268","display_name":"Leticia Campo","orcid":"https://orcid.org/0000-0002-4714-0188"},"institutions":[{"id":"https://openalex.org/I4210146410","display_name":"Science Oxford","ror":"https://ror.org/04j8yhy50","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210146410"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Leticia Campo","raw_affiliation_strings":["Institute of Biomedical Engineering, University of Oxford,Department of Engineering Sci-ence,Oxford,UK","Department of Engineering Sci-ence, Institute of Biomedical Engineering, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, University of Oxford,Department of Engineering Sci-ence,Oxford,UK","institution_ids":["https://openalex.org/I4210146410"]},{"raw_affiliation_string":"Department of Engineering Sci-ence, Institute of Biomedical Engineering, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034964857","display_name":"Helen Jones","orcid":"https://orcid.org/0000-0001-8238-7779"},"institutions":[{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen Jones","raw_affiliation_strings":["Oxford University Hospitals NHS Trust,Department of Colorectal Surgery,Oxford,UK","Department of Colorectal Surgery, Oxford University Hospitals NHS Trust, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Oxford University Hospitals NHS Trust,Department of Colorectal Surgery,Oxford,UK","institution_ids":["https://openalex.org/I4210147381"]},{"raw_affiliation_string":"Department of Colorectal Surgery, Oxford University Hospitals NHS Trust, Oxford, UK","institution_ids":["https://openalex.org/I4210147381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004776968","display_name":"David C. Wedge","orcid":"https://orcid.org/0000-0002-7572-3196"},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"funder","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210129527"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David C. Wedge","raw_affiliation_strings":["University of Manchester,Manchester Cancer Research Centre,Manch-ester,UK","Manchester Cancer Research Centre, University of Manchester, Manch-ester, UK"],"affiliations":[{"raw_affiliation_string":"University of Manchester,Manchester Cancer Research Centre,Manch-ester,UK","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I2801316944"]},{"raw_affiliation_string":"Manchester Cancer Research Centre, University of Manchester, Manch-ester, UK","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649922","display_name":"Chris Holmes","orcid":"https://orcid.org/0000-0002-6667-4943"},"institutions":[{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Holmes","raw_affiliation_strings":["Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","Department of Statistics, University of Oxford, Oxford, UK","Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","institution_ids":["https://openalex.org/I4210142469","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Statistics, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037405971","display_name":"Korsuk Sirinukunwattana","orcid":"https://orcid.org/0000-0002-3603-4435"},"institutions":[{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Korsuk Sirinukunwattana","raw_affiliation_strings":["Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","Department of Engineering Sci-ence, Institute of Biomedical Engineering, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","institution_ids":["https://openalex.org/I4210142469","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Engineering Sci-ence, Institute of Biomedical Engineering, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068600717","display_name":"Heba Sailem","orcid":"https://orcid.org/0000-0002-6600-1255"},"institutions":[{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Heba Sailem","raw_affiliation_strings":["Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","Department of Engineering Sci-ence, Institute of Biomedical Engineering, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","institution_ids":["https://openalex.org/I4210142469","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Engineering Sci-ence, Institute of Biomedical Engineering, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090096123","display_name":"Clare Verrill","orcid":"https://orcid.org/0000-0002-4905-8233"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210146357","display_name":"Oxford BioMedica (United Kingdom)","ror":"https://ror.org/03dp0vf82","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146357"]},{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clare Verrill","raw_affiliation_strings":["Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","NIHR Oxford Biomedical Research Centre, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","institution_ids":["https://openalex.org/I4210142469","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"NIHR Oxford Biomedical Research Centre, Oxford, UK","institution_ids":["https://openalex.org/I4210146357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027416348","display_name":"Jens Rittscher","orcid":"https://orcid.org/0000-0002-8528-8298"},"institutions":[{"id":"https://openalex.org/I4210146357","display_name":"Oxford BioMedica (United Kingdom)","ror":"https://ror.org/03dp0vf82","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146357"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jens Rittscher","raw_affiliation_strings":["Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","Department of Engineering Sci-ence, Institute of Biomedical Engineering, University of Oxford, Oxford, UK","Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","NIHR Oxford Biomedical Research Centre, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Big Data Institute, University of Oxford,Li Ka Shing Centre for Health Information and Discovery,Oxford,UK","institution_ids":["https://openalex.org/I4210142469","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Engineering Sci-ence, Institute of Biomedical Engineering, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"NIHR Oxford Biomedical Research Centre, Oxford, UK","institution_ids":["https://openalex.org/I4210146357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5040225784"],"corresponding_institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210142469"],"apc_list":null,"apc_paid":null,"fwci":3.5211,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.93784422,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"2022","issue":null,"first_page":"3063","last_page":"3067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6567059755325317},{"id":"https://openalex.org/keywords/multiplexing","display_name":"Multiplexing","score":0.5926099419593811},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5412748456001282},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5005805492401123},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3993600010871887},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2975839674472809},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.20167329907417297},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2009117305278778},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.09335565567016602}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6567059755325317},{"id":"https://openalex.org/C19275194","wikidata":"https://www.wikidata.org/wiki/Q222903","display_name":"Multiplexing","level":2,"score":0.5926099419593811},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5412748456001282},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5005805492401123},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3993600010871887},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2975839674472809},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.20167329907417297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2009117305278778},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.09335565567016602}],"mesh":[{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc48229.2022.9871251","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871251","pdf_url":"https://ieeexplore.ieee.org/ielx7/9870821/9870822/09871251.pdf","source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36085678","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36085678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/c21f713f-43f9-4b7e-8875-528d56ac3971","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/c21f713f-43f9-4b7e-8875-528d56ac3971","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Martin, N G, Campo, L, Wedge, D C, Holmes, C, Sirinukunwattana, K, Sailem, H, Verrill, C & Rittscher, J 2022, 'A Graph Based Neural Network Approach to Immune Profiling of Multiplexed Tissue Samples', Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, vol. 2022, pp. 3063-3067. https://doi.org/10.1109/EMBC48229.2022.9871251","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1109/embc48229.2022.9871251","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871251","pdf_url":"https://ieeexplore.ieee.org/ielx7/9870821/9870822/09871251.pdf","source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1204174473","display_name":null,"funder_award_id":"C2195/A27450","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G1934935867","display_name":null,"funder_award_id":"Engineering and Physical Sciences R","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2583680303","display_name":null,"funder_award_id":"CIFMS","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G4198845526","display_name":"EPSRC and MRC Centre for Doctoral Training in Biomedical Imaging","funder_award_id":"EP/L016052/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4632173870","display_name":null,"funder_award_id":"EP/L016052/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4669774001","display_name":null,"funder_award_id":"2018-I2M-2-002","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G4743594581","display_name":null,"funder_award_id":"EP/L016052","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6653872853","display_name":null,"funder_award_id":"EP/L016","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G920613653","display_name":null,"funder_award_id":"204724/Z/16/Z","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320335846","display_name":"Biomedical Research Council","ror":"https://ror.org/03xy0wx88"},{"id":"https://openalex.org/F4320336045","display_name":"NIHR Oxford Biomedical Research Centre","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4294975154.pdf","grobid_xml":"https://content.openalex.org/works/W4294975154.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W2019062120","https://openalex.org/W2053725511","https://openalex.org/W2058333183","https://openalex.org/W2086335524","https://openalex.org/W2092772483","https://openalex.org/W2126563020","https://openalex.org/W2132022337","https://openalex.org/W2194775991","https://openalex.org/W2344591493","https://openalex.org/W2594633041","https://openalex.org/W2622865236","https://openalex.org/W2890156321","https://openalex.org/W2918342466","https://openalex.org/W2922124692","https://openalex.org/W2962711740","https://openalex.org/W2962810718","https://openalex.org/W2964015378","https://openalex.org/W3085380432","https://openalex.org/W3096587759","https://openalex.org/W4288419263","https://openalex.org/W6639824700","https://openalex.org/W6726873649","https://openalex.org/W6734194636","https://openalex.org/W6754929296","https://openalex.org/W6760753967"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2382290278"],"abstract_inverted_index":{"Multiplexed":[0],"immunofluorescence":[1],"provides":[2],"an":[3],"un-precedented":[4],"opportunity":[5,70],"for":[6],"studying":[7],"specific":[8],"cell-to-cell":[9],"and":[10,49,66],"cell":[11],"microenvironment":[12,35],"interactions.":[13,75],"We":[14],"employ":[15],"graph":[16],"neural":[17],"networks":[18],"to":[19,31,47,71],"combine":[20],"features":[21],"obtained":[22],"from":[23],"tissue":[24],"morphology":[25],"with":[26,37],"measurements":[27],"of":[28,58],"protein":[29],"expression":[30],"profile":[32],"the":[33,59,69],"tumour":[34,39],"associated":[36],"different":[38],"stages.":[40],"Our":[41],"framework":[42],"presents":[43],"a":[44],"new":[45],"approach":[46],"analysing":[48,63],"processing":[50],"these":[51,64],"complex":[52],"multi-dimensional":[53],"datasets":[54],"that":[55],"overcomes":[56],"some":[57],"key":[60],"challenges":[61],"in":[62],"data":[65],"opens":[67],"up":[68],"abstract":[72],"biologically":[73],"meaningful":[74]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
