{"id":"https://openalex.org/W4295074183","doi":"https://doi.org/10.1109/embc48229.2022.9871205","title":"Cerebellum involvement in dystonia: insights from a spiking neural network model during associative learning","display_name":"Cerebellum involvement in dystonia: insights from a spiking neural network model during associative learning","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4295074183","doi":"https://doi.org/10.1109/embc48229.2022.9871205","pmid":"https://pubmed.ncbi.nlm.nih.gov/36086302"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871205","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871205","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041703283","display_name":"Alice Geminiani","orcid":"https://orcid.org/0000-0002-9407-8719"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alice Geminiani","raw_affiliation_strings":["University of Pavia,Department of Brain and Behavioral Sciences,Pavia,Italy,27100"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia,Department of Brain and Behavioral Sciences,Pavia,Italy,27100","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089203606","display_name":"Aurimas Mockevi\u010dius","orcid":"https://orcid.org/0009-0006-9368-0093"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Aurimas Mockevicius","raw_affiliation_strings":["University of Pavia,Department of Brain and Behavioral Sciences,Pavia,Italy,27100"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia,Department of Brain and Behavioral Sciences,Pavia,Italy,27100","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060051804","display_name":"Egidio D\u2019Angelo","orcid":"https://orcid.org/0000-0002-6007-7187"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Egidio D'Angelo","raw_affiliation_strings":["University of Pavia,Department of Brain and Behavioral Sciences,Pavia,Italy,27100","IRCCS Mondino Foundation, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia,Department of Brain and Behavioral Sciences,Pavia,Italy,27100","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"IRCCS Mondino Foundation, Pavia, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006185953","display_name":"Claudia Casellato","orcid":"https://orcid.org/0000-0002-8729-0391"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Casellato","raw_affiliation_strings":["University of Pavia,Department of Brain and Behavioral Sciences,Pavia,Italy,27100"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia,Department of Brain and Behavioral Sciences,Pavia,Italy,27100","institution_ids":["https://openalex.org/I25217355"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2094,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.33478261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"2022","issue":null,"first_page":"5132","last_page":"5135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eyeblink-conditioning","display_name":"Eyeblink conditioning","score":0.8810773491859436},{"id":"https://openalex.org/keywords/cerebellum","display_name":"Cerebellum","score":0.795199990272522},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7872087359428406},{"id":"https://openalex.org/keywords/dystonia","display_name":"Dystonia","score":0.7489884495735168},{"id":"https://openalex.org/keywords/motor-learning","display_name":"Motor learning","score":0.6910839676856995},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.5441144704818726},{"id":"https://openalex.org/keywords/associative-learning","display_name":"Associative learning","score":0.5435426831245422},{"id":"https://openalex.org/keywords/cerebellar-cortex","display_name":"Cerebellar cortex","score":0.5294216275215149},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"Basal ganglia","score":0.4549734592437744},{"id":"https://openalex.org/keywords/motor-cortex","display_name":"Motor cortex","score":0.43074145913124084},{"id":"https://openalex.org/keywords/classical-conditioning","display_name":"Classical conditioning","score":0.42773890495300293},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.19883662462234497},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.18583041429519653},{"id":"https://openalex.org/keywords/conditioning","display_name":"Conditioning","score":0.15963837504386902}],"concepts":[{"id":"https://openalex.org/C2781081984","wikidata":"https://www.wikidata.org/wiki/Q5422751","display_name":"Eyeblink conditioning","level":4,"score":0.8810773491859436},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.795199990272522},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7872087359428406},{"id":"https://openalex.org/C2778559928","wikidata":"https://www.wikidata.org/wiki/Q906492","display_name":"Dystonia","level":2,"score":0.7489884495735168},{"id":"https://openalex.org/C107690735","wikidata":"https://www.wikidata.org/wiki/Q852461","display_name":"Motor learning","level":2,"score":0.6910839676856995},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5441144704818726},{"id":"https://openalex.org/C2983526489","wikidata":"https://www.wikidata.org/wiki/Q133500","display_name":"Associative learning","level":2,"score":0.5435426831245422},{"id":"https://openalex.org/C2992333117","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellar cortex","level":3,"score":0.5294216275215149},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.4549734592437744},{"id":"https://openalex.org/C2778373776","wikidata":"https://www.wikidata.org/wiki/Q18696","display_name":"Motor cortex","level":3,"score":0.43074145913124084},{"id":"https://openalex.org/C39617858","wikidata":"https://www.wikidata.org/wiki/Q212737","display_name":"Classical conditioning","level":3,"score":0.42773890495300293},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.19883662462234497},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.18583041429519653},{"id":"https://openalex.org/C45262634","wikidata":"https://www.wikidata.org/wiki/Q5159291","display_name":"Conditioning","level":2,"score":0.15963837504386902},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001767","descriptor_name":"Blinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001767","descriptor_name":"Blinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001767","descriptor_name":"Blinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003214","descriptor_name":"Conditioning, Classical","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003214","descriptor_name":"Conditioning, Classical","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003214","descriptor_name":"Conditioning, Classical","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004421","descriptor_name":"Dystonia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004421","descriptor_name":"Dystonia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004421","descriptor_name":"Dystonia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc48229.2022.9871205","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871205","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36086302","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36086302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.6299999952316284}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W644875736","https://openalex.org/W879505599","https://openalex.org/W2031937032","https://openalex.org/W2045102824","https://openalex.org/W2061083553","https://openalex.org/W2115752493","https://openalex.org/W2147478804","https://openalex.org/W2220734730","https://openalex.org/W2403384342","https://openalex.org/W2562392420","https://openalex.org/W2570641660","https://openalex.org/W2605002006","https://openalex.org/W2613454693","https://openalex.org/W2894976494","https://openalex.org/W2948227879","https://openalex.org/W2978564343","https://openalex.org/W3160823891","https://openalex.org/W3192731151","https://openalex.org/W4237519055"],"related_works":["https://openalex.org/W2080473762","https://openalex.org/W2321268899","https://openalex.org/W2051629081","https://openalex.org/W2030263206","https://openalex.org/W1980284406","https://openalex.org/W2026363346","https://openalex.org/W2491923983","https://openalex.org/W2083049700","https://openalex.org/W2006891140","https://openalex.org/W2278390842"],"abstract_inverted_index":{"Dystonia":[0],"is":[1,44,147,155],"a":[2,54,79,97,132],"neurological":[3],"movement":[4],"disorder":[5],"characterized":[6],"by":[7,96,109],"twisting":[8],"and":[9,60],"repetitive":[10],"movements":[11],"or":[12,236],"abnormal":[13],"fixed":[14],"postures.":[15],"This":[16],"complex":[17],"brain":[18,238],"disease":[19],"has":[20],"usually":[21],"been":[22,76],"associated":[23,176],"with":[24,62,139,177],"damages":[25,65],"to":[26,118,130,149,197,215,244],"the":[27,35,39,71,102,111,115,156,167,170,178,199,208,223,242],"Basal":[28],"Ganglia.":[29],"However,":[30],"recent":[31],"studies":[32,229],"point":[33],"out":[34],"potential":[36,80],"role":[37],"of":[38,83,92,101,135,158,165,173,184,192,205,225,234],"cerebellum.":[40,103],"Indeed,":[41,144,207],"motor":[42,137,160,226],"learning":[43,58],"impaired":[45],"in":[46,70,123,181,189,202,222,248],"dystonic":[47,67],"patients,":[48],"e.g.":[49],"during":[50],"eyeblink":[51,93,136,209],"classical":[52],"conditioning,":[53],"typical":[55],"cerebellum-driven":[56,159],"associative":[57],"protocol,":[59],"rodents":[61],"local":[63],"cerebellar":[64,119,151,200],"exhibit":[66],"movements.":[68],"Alterations":[69],"olivocerebellar":[72],"circuit":[73],"connectivity":[74],"have":[75],"identified":[77],"as":[78,121],"neural":[81],"substrate":[82],"dystonia.":[84,206],"Here,":[85],"we":[86],"investigated":[87],"this":[88,145],"hypothesis":[89],"through":[90],"simulations":[91,233],"conditioning":[94,210],"driven":[95],"realistic":[98],"spiking":[99],"model":[100,106,127,168],"The":[104,126],"pathological":[105],"was":[107,128],"generated":[108],"decreasing":[110],"signal":[112],"transmission":[113],"from":[114],"Inferior":[116],"Olive":[117],"cortex,":[120],"observed":[122,180],"animal":[124],"experiments.":[125],"able":[129],"reproduce":[131],"reduced":[133],"acquisition":[134],"responses,":[138],"also":[140,231],"an":[141],"unproper":[142],"timing.":[143],"pathway":[146],"fundamental":[148],"drive":[150],"cortical":[152],"plasticity,":[153],"which":[154],"basis":[157],"learning.":[161],"Exploring":[162],"different":[163,203],"levels":[164],"damage,":[166],"predicted":[169],"possible":[171],"amount":[172],"underlying":[174],"impairment":[175],"misbehavior":[179],"patients.":[182],"Simulations":[183],"other":[185],"debated":[186],"lesions":[187],"reported":[188],"mouse":[190],"models":[191],"dystonia":[193],"will":[194,230],"be":[195,213],"run":[196],"investigate":[198],"involvement":[201],"types":[204],"phenotype":[211],"could":[212],"used":[214],"discriminate":[216],"between":[217],"them,":[218],"identifying":[219],"specific":[220],"deficits":[221],"generation":[224],"responses.":[227],"Future":[228],"include":[232],"pharmacological":[235],"deep":[237],"stimulation":[239],"treatments":[240],"targeting":[241],"cerebellum,":[243],"predict":[245],"their":[246],"impact":[247],"improving":[249],"symptoms.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
