{"id":"https://openalex.org/W4294976032","doi":"https://doi.org/10.1109/embc48229.2022.9871185","title":"Closed-Loop Control of Arterial CO<sub>2</sub> in Mechanical Ventilation of Neonates","display_name":"Closed-Loop Control of Arterial CO<sub>2</sub> in Mechanical Ventilation of Neonates","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4294976032","doi":"https://doi.org/10.1109/embc48229.2022.9871185","pmid":"https://pubmed.ncbi.nlm.nih.gov/36083943"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871185","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871185","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034584579","display_name":"Mateusz Buglowski","orcid":"https://orcid.org/0009-0003-9591-7953"},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mateusz Buglowski","raw_affiliation_strings":["RWTH Aachen University,Informatik 11 - Embedded Software,Aachen,Germany","Informatik 11 - Embedded Software, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University,Informatik 11 - Embedded Software,Aachen,Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Informatik 11 - Embedded Software, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001997171","display_name":"Valerie Pfannschmidt","orcid":null},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Valerie Pfannschmidt","raw_affiliation_strings":["RWTH Aachen University,Informatik 11 - Embedded Software,Aachen,Germany","Informatik 11 - Embedded Software, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University,Informatik 11 - Embedded Software,Aachen,Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Informatik 11 - Embedded Software, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031501347","display_name":"Sabine Becker","orcid":null},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Becker","raw_affiliation_strings":["RWTH Aachen University Hospital,Neonatology Section,Department of Paediatric and Adolescent Medicine,Aachen,Germany","Department of Paediatric and Adolescent Medicine, Neonatology Section, RWTH Aachen University Hospital, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University Hospital,Neonatology Section,Department of Paediatric and Adolescent Medicine,Aachen,Germany","institution_ids":["https://openalex.org/I887968799","https://openalex.org/I4210120689"]},{"raw_affiliation_string":"Department of Paediatric and Adolescent Medicine, Neonatology Section, RWTH Aachen University Hospital, Aachen, Germany","institution_ids":["https://openalex.org/I887968799","https://openalex.org/I4210120689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017904021","display_name":"Oliver Braun","orcid":"https://orcid.org/0000-0001-5155-3033"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliver Braun","raw_affiliation_strings":["L&#x00F6;wenstein Medical SE &#x0026; Co. KG,Bad Ems,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L&#x00F6;wenstein Medical SE &#x0026; Co. KG,Bad Ems,Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015589373","display_name":"Matthi\ufeffas C. H\u00fctten","orcid":"https://orcid.org/0000-0003-4870-5782"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Matthias Hutten","raw_affiliation_strings":["School of Oncology and Developmental Biology (GROW), Maastricht University,Department of Pediatrics,Maastricht,The Netherlands,6202 AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Oncology and Developmental Biology (GROW), Maastricht University,Department of Pediatrics,Maastricht,The Netherlands,6202 AZ","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001595908","display_name":"Daan R. M. G. Ophelders","orcid":"https://orcid.org/0000-0001-7410-5102"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Daan Ophelders","raw_affiliation_strings":["School of Oncology and Developmental Biology (GROW), Maastricht University,Department of Pediatrics,Maastricht,The Netherlands,6202 AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Oncology and Developmental Biology (GROW), Maastricht University,Department of Pediatrics,Maastricht,The Netherlands,6202 AZ","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102178814","display_name":"Camelia Oprea","orcid":null},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Camelia Oprea","raw_affiliation_strings":["RWTH Aachen University,Informatik 11 - Embedded Software,Aachen,Germany","Informatik 11 - Embedded Software, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University,Informatik 11 - Embedded Software,Aachen,Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Informatik 11 - Embedded Software, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012702566","display_name":"Steffen Pattai","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steffen Pattai","raw_affiliation_strings":["L&#x00F6;wenstein Medical SE &#x0026; Co. KG,Bad Ems,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L&#x00F6;wenstein Medical SE &#x0026; Co. KG,Bad Ems,Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110027449","display_name":"Mark Schoberer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mark Schoberer","raw_affiliation_strings":["RWTH Aachen University Hospital,Neonatology Section,Department of Paediatric and Adolescent Medicine,Aachen,Germany","Department of Paediatric and Adolescent Medicine, Neonatology Section, RWTH Aachen University Hospital, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University Hospital,Neonatology Section,Department of Paediatric and Adolescent Medicine,Aachen,Germany","institution_ids":["https://openalex.org/I887968799","https://openalex.org/I4210120689"]},{"raw_affiliation_string":"Department of Paediatric and Adolescent Medicine, Neonatology Section, RWTH Aachen University Hospital, Aachen, Germany","institution_ids":["https://openalex.org/I887968799","https://openalex.org/I4210120689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060790136","display_name":"Andr\u00e9 Stollenwerk","orcid":"https://orcid.org/0000-0002-9195-535X"},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andre Stollenwerk","raw_affiliation_strings":["RWTH Aachen University,Informatik 11 - Embedded Software,Aachen,Germany","Informatik 11 - Embedded Software, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University,Informatik 11 - Embedded Software,Aachen,Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Informatik 11 - Embedded Software, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5034584579"],"corresponding_institution_ids":["https://openalex.org/I887968799"],"apc_list":null,"apc_paid":null,"fwci":5.2654,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.95448954,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"2022","issue":null,"first_page":"4991","last_page":"4995"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.4504009485244751},{"id":"https://openalex.org/keywords/ventilation","display_name":"Ventilation (architecture)","score":0.42091476917266846},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4092964231967926},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.25388702750205994},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24123340845108032},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.09563273191452026}],"concepts":[{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.4504009485244751},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.42091476917266846},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4092964231967926},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.25388702750205994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24123340845108032},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.09563273191452026},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc48229.2022.9871185","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871185","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36083943","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36083943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire_cris_publications/9d201492-8ee8-4cba-a64d-01df7be9ce33","is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/9d201492-8ee8-4cba-a64d-01df7be9ce33","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Buglowski, M, Pfannschmidt, V, Becker, S, Braun, O, Hutten, M, Ophelders, D, Oprea, C, Pattai, S, Schoberer, M & Stollenwerk, A 2022, Closed-Loop Control of Arterial CO2 in Mechanical Ventilation of Neonates. in 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). vol. 2022, IEEE, IEEE Engineering in Medicine and Biology Society. Annual International Conference Proceedings, pp. 4991-4995. https://doi.org/10.1109/EMBC48229.2022.9871185","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1471981189","display_name":null,"funder_award_id":"13GW0292C","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1516055747","https://openalex.org/W1984853170","https://openalex.org/W2027134023","https://openalex.org/W2102806222","https://openalex.org/W2113276226","https://openalex.org/W2135477731","https://openalex.org/W2170348418","https://openalex.org/W2225287332","https://openalex.org/W2795949677","https://openalex.org/W2898963498","https://openalex.org/W3013693534","https://openalex.org/W4250370005","https://openalex.org/W6689435565"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2382290278"],"abstract_inverted_index":{"remains":[0],"a":[1,30],"critical":[2],"aspect":[3],"that":[4],"needs":[5],"to":[6,19,25],"be":[7],"further":[8],"investigated.":[9],"Clinical":[10],"relevance-Closed-loop":[11],"control":[12],"of":[13],"CO2":[14],"in":[15],"mechanical":[16],"ventilation":[17],"aims":[18],"avoid":[20],"PaC":[21],"O2":[22],"extremes":[23],"and":[24],"reduce":[26],"fluctuations.":[27],"Both":[28],"are":[29],"relevant":[31],"risk":[32],"factors":[33],"especially":[34],"for":[35],"neurological":[36],"complications":[37],"among":[38],"preterm":[39],"newborns.":[40]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}