{"id":"https://openalex.org/W4295509545","doi":"https://doi.org/10.1109/embc48229.2022.9871160","title":"Automated Retinal Vascular Topological Information Extraction From OCTA","display_name":"Automated Retinal Vascular Topological Information Extraction From OCTA","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4295509545","doi":"https://doi.org/10.1109/embc48229.2022.9871160","pmid":"https://pubmed.ncbi.nlm.nih.gov/36086557"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871160","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871160","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082355690","display_name":"Ashe X. Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Ashe X. Lee","raw_affiliation_strings":["Singapore Eye Research Institute,Ocular Imaging,Singapore","Ocular Imaging, Singapore Eye Research Institute, Singapore"],"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute,Ocular Imaging,Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Ocular Imaging, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075739031","display_name":"Ashish Saxena","orcid":"https://orcid.org/0000-0003-3353-129X"},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ashish Saxena","raw_affiliation_strings":["Singapore Eye Research Institute,Ocular Imaging,Singapore","SERI-NTU Advanced Ocular Engineering (STANCE), Singapore","Ocular Imaging, Singapore Eye Research Institute, Singapore"],"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute,Ocular Imaging,Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"SERI-NTU Advanced Ocular Engineering (STANCE), Singapore","institution_ids":[]},{"raw_affiliation_string":"Ocular Imaging, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030728121","display_name":"Jacqueline Chua","orcid":"https://orcid.org/0000-0002-6474-5293"},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jacqueline Chua","raw_affiliation_strings":["Singapore Eye Research Institute,Ocular Imaging,Singapore","Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore","Ocular Imaging, Singapore Eye Research Institute, Singapore","SERI-NTU Advanced Ocular Engineering (STANCE), Singapore"],"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute,Ocular Imaging,Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore","institution_ids":["https://openalex.org/I4210126319"]},{"raw_affiliation_string":"Ocular Imaging, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"SERI-NTU Advanced Ocular Engineering (STANCE), Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015017045","display_name":"Leopold Schmetterer","orcid":"https://orcid.org/0000-0002-7189-1707"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Leopold Schmetterer","raw_affiliation_strings":["Singapore Eye Research Institute,Ocular Imaging,Singapore","SERI-NTU Advanced Ocular Engineering (STANCE), Singapore","Ocular Imaging, Singapore Eye Research Institute, Singapore","School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore"],"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute,Ocular Imaging,Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"SERI-NTU Advanced Ocular Engineering (STANCE), Singapore","institution_ids":[]},{"raw_affiliation_string":"Ocular Imaging, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072145894","display_name":"Bingyao Tan","orcid":"https://orcid.org/0000-0002-6532-9603"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Bingyao Tan","raw_affiliation_strings":["Singapore Eye Research Institute,Ocular Imaging,Singapore","SERI-NTU Advanced Ocular Engineering (STANCE), Singapore","School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore","Ocular Imaging, Singapore Eye Research Institute, Singapore"],"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute,Ocular Imaging,Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"SERI-NTU Advanced Ocular Engineering (STANCE), Singapore","institution_ids":[]},{"raw_affiliation_string":"School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Ocular Imaging, Singapore Eye Research Institute, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5082355690"],"corresponding_institution_ids":["https://openalex.org/I4210116917"],"apc_list":null,"apc_paid":null,"fwci":0.6705,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.69420745,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"2022","issue":null,"first_page":"1839","last_page":"1842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal","display_name":"Retinal","score":0.6402519941329956},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5799306631088257},{"id":"https://openalex.org/keywords/glaucoma","display_name":"Glaucoma","score":0.4955943822860718},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48266151547431946},{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"Optical coherence tomography","score":0.4805094003677368},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.47160109877586365},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"Diabetic retinopathy","score":0.46961337327957153},{"id":"https://openalex.org/keywords/macular-degeneration","display_name":"Macular degeneration","score":0.4209884703159332},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.40031546354293823},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3341371417045593},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3243488669395447},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.3233029246330261}],"concepts":[{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6402519941329956},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5799306631088257},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.4955943822860718},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48266151547431946},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.4805094003677368},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.47160109877586365},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.46961337327957153},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.4209884703159332},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.40031546354293823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3341371417045593},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3243488669395447},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3233029246330261},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc48229.2022.9871160","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871160","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36086557","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36086557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4399999976158142,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W1909185046","https://openalex.org/W2174711832","https://openalex.org/W2572945848","https://openalex.org/W2590925679","https://openalex.org/W2916950160","https://openalex.org/W2971614929","https://openalex.org/W3035452548","https://openalex.org/W3048610712","https://openalex.org/W3068821485","https://openalex.org/W3098652539","https://openalex.org/W3160252910"],"related_works":["https://openalex.org/W4360991425","https://openalex.org/W2994531931","https://openalex.org/W2049145612","https://openalex.org/W2085450444","https://openalex.org/W4386789577","https://openalex.org/W4246192989","https://openalex.org/W2500847435","https://openalex.org/W1014602304","https://openalex.org/W1033756233","https://openalex.org/W2744576618"],"abstract_inverted_index":{"The":[0],"retinal":[1],"vascular":[2,30],"system":[3],"adapts":[4],"and":[5,16,48,52,60,65,81,113],"reacts":[6],"rapidly":[7],"to":[8,27,77],"ocular":[9],"diseases":[10],"such":[11],"as":[12],"glaucoma,":[13],"diabetic":[14],"retinopathy":[15],"age-related":[17],"macular":[18],"degeneration.":[19],"Here":[20],"we":[21],"present":[22],"a":[23,55],"combination":[24],"of":[25,50,58,63,83,91,99,110],"methods":[26],"further":[28],"extract":[29],"information":[31,74],"from":[32],"[Formula:":[33],"see":[34],"text]":[35],"wide-field":[36],"optical":[37],"coherence":[38],"tomography":[39],"angiography":[40],"(OCTA).":[41],"An":[42],"integrated":[43],"U-Net":[44],"for":[45],"the":[46,79,84,96,107],"segmentation":[47,56],"classification":[49,61],"arteries":[51],"veins":[53],"reached":[54],"IoU":[57,62],"0.7095\u00b10.0224,":[59],"0.8793\u00b10.1049":[64],"0.8928\u00b10.0929":[66],"respectively.":[67],"A":[68],"correcting":[69],"algorithm":[70],"which":[71,86],"uses":[72],"topological":[73],"was":[75,102],"created":[76],"correct":[78],"misclassification":[80],"connectivity":[82],"vessels,":[85],"showed":[87],"an":[88],"average":[89],"increase":[90],"8.29%":[92],"in":[93],"IoU.":[94],"Finally,":[95],"vessel":[97],"morphometry":[98],"branch":[100],"orders":[101],"extracted,":[103],"where":[104],"this":[105],"allows":[106],"direct":[108],"comparison":[109],"artery/vein,":[111],"arterioles/venules":[112],"capillaries.":[114]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-01-21T23:30:37.877113","created_date":"2025-10-10T00:00:00"}
