{"id":"https://openalex.org/W4295424666","doi":"https://doi.org/10.1109/embc48229.2022.9871141","title":"Analysis of Brain-Heart Interactions in newborns with and without seizures using the Convergent Cross Mapping approach","display_name":"Analysis of Brain-Heart Interactions in newborns with and without seizures using the Convergent Cross Mapping approach","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4295424666","doi":"https://doi.org/10.1109/embc48229.2022.9871141","pmid":"https://pubmed.ncbi.nlm.nih.gov/36086480"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871141","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871141","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2158/1282821","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067221769","display_name":"Lorenzo Frassineti","orcid":"https://orcid.org/0000-0001-7455-5656"},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Lorenzo Frassineti","raw_affiliation_strings":["Universit&#x00E0; degli Studi di Firenze,Department of Information Engineering,Firenze,Italy"],"affiliations":[{"raw_affiliation_string":"Universit&#x00E0; degli Studi di Firenze,Department of Information Engineering,Firenze,Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022434697","display_name":"Claudia Manfredi","orcid":"https://orcid.org/0000-0001-6364-9753"},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Manfredi","raw_affiliation_strings":["Universit&#x00E0; degli Studi di Firenze,Department of Information Engineering,Firenze,Italy"],"affiliations":[{"raw_affiliation_string":"Universit&#x00E0; degli Studi di Firenze,Department of Information Engineering,Firenze,Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054954655","display_name":"Daniele Ermini","orcid":null},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele Ermini","raw_affiliation_strings":["School of Engineering, Universit&#x00E0; degli Studi di Firenze,Firenze,Italy"],"affiliations":[{"raw_affiliation_string":"School of Engineering, Universit&#x00E0; degli Studi di Firenze,Firenze,Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050297075","display_name":"Rachele Fabbri","orcid":"https://orcid.org/0000-0002-7589-8367"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rachele Fabbri","raw_affiliation_strings":["University of Pisa,Department of Information Engineering,Pisa,Italy","Department of Information Engineering, University of Pisa, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"University of Pisa,Department of Information Engineering,Pisa,Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Department of Information Engineering, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003090063","display_name":"Benedetta Olmi","orcid":"https://orcid.org/0000-0002-6291-1120"},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Benedetta Olmi","raw_affiliation_strings":["Universit&#x00E0; degli Studi di Firenze,Department of Information Engineering,Firenze,Italy"],"affiliations":[{"raw_affiliation_string":"Universit&#x00E0; degli Studi di Firenze,Department of Information Engineering,Firenze,Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040595723","display_name":"Antonio Lanat\u00e0","orcid":"https://orcid.org/0000-0002-6540-5952"},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Lanata","raw_affiliation_strings":["Universit&#x00E0; degli Studi di Firenze,Department of Information Engineering,Firenze,Italy"],"affiliations":[{"raw_affiliation_string":"Universit&#x00E0; degli Studi di Firenze,Department of Information Engineering,Firenze,Italy","institution_ids":["https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5067221769"],"corresponding_institution_ids":["https://openalex.org/I45084792"],"apc_list":null,"apc_paid":null,"fwci":0.8024,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66784038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"2022","issue":null,"first_page":"36","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5425330996513367},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.4897751808166504},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.34816646575927734},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.19800525903701782}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5425330996513367},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4897751808166504},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34816646575927734},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.19800525903701782}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc48229.2022.9871141","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871141","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36086480","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36086480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:flore.unifi.it:2158/1282821","is_oa":true,"landing_page_url":"http://hdl.handle.net/2158/1282821","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:flore.unifi.it:2158/1282821","is_oa":true,"landing_page_url":"http://hdl.handle.net/2158/1282821","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5899999737739563}],"awards":[],"funders":[{"id":"https://openalex.org/F4320313975","display_name":"Universit\u00e0 degli Studi di Siena","ror":"https://ror.org/01tevnk56"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W2011805513","https://openalex.org/W2083278075","https://openalex.org/W2162273778","https://openalex.org/W2327416138","https://openalex.org/W2333032581","https://openalex.org/W2411514576","https://openalex.org/W2810899922","https://openalex.org/W2886478704","https://openalex.org/W2916154230","https://openalex.org/W2918225995","https://openalex.org/W2981764557","https://openalex.org/W2990430870","https://openalex.org/W3006679747","https://openalex.org/W3042424020","https://openalex.org/W3080952300","https://openalex.org/W3109672150","https://openalex.org/W3129128079","https://openalex.org/W3164057060","https://openalex.org/W3171389528","https://openalex.org/W3197747318","https://openalex.org/W3202842840","https://openalex.org/W3211388146"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2395385109","https://openalex.org/W2773633178","https://openalex.org/W2080101436","https://openalex.org/W2802335767","https://openalex.org/W2356350882","https://openalex.org/W4388090985","https://openalex.org/W2390279801","https://openalex.org/W1545074592"],"abstract_inverted_index":{"In":[0],"the":[1,4,28,38,44,51,58,64,113,116,138,160,163,173,176],"last":[2],"years,":[3],"characterization":[5],"of":[6,25,57,67,92,110,128,148,175],"brain-heart":[7],"interactions":[8],"(BHIs)":[9],"in":[10,63,74,150],"epilepsy":[11],"has":[12],"gained":[13],"great":[14],"interest.":[15],"For":[16],"some":[17],"specific":[18],"seizures":[19,79,105,153],"there":[20],"is":[21,50],"still":[22],"a":[23,90,96,107,182],"lack":[24],"information":[26],"about":[27],"mechanisms":[29,140],"occurring":[30],"during":[31,178],"or":[32,162,179],"close":[33,180],"to":[34,89,135,157,181],"ictal":[35,166],"events":[36],"between":[37,76,112],"central":[39],"nervous":[40,46],"system":[41,47],"(CNS)":[42],"and":[43,80,115],"autonomic":[45],"(ANS).":[48],"This":[49,69],"case":[52],"for":[53,131],"neonatal":[54,142,183],"seizures,":[55],"one":[56],"most":[59],"common":[60],"neurological":[61],"emergencies":[62],"first":[65],"days":[66],"life.":[68],"paper":[70],"evaluates":[71],"possible":[72],"differences":[73],"BHIs":[75,149],"newborns":[77,94,103,151],"with":[78,104,152],"seizure-free":[81,119],"ones.":[82],"We":[83],"applied":[84],"convergent":[85],"cross":[86],"mapping":[87],"approaches":[88,134,170],"cohort":[91],"52":[93],"from":[95],"public":[97],"dataset.":[98],"Preliminary":[99],"results":[100,126],"show":[101],"that":[102],"have":[106],"lower":[108],"degree":[109],"interaction":[111],"CNS":[114],"ANS":[117,177],"than":[118],"ones":[120],"(Mann-Whitney":[121],"test:":[122],"p-value":[123],"<0.05).":[124],"These":[125],"are":[127],"clinical":[129],"relevance":[130],"future":[132],"BHI-based":[133],"better":[136,158],"understand":[137],"neural":[139],"behind":[141,165],"seizures.":[143],"Clinical":[144],"Relevance-":[145],"The":[146],"study":[147],"might":[154],"be":[155],"helpful":[156],"characterize":[159],"disorder":[161],"aetiologies":[164],"events.":[167],"Moreover,":[168],"BHI":[169],"may":[171],"confirm":[172],"involvement":[174],"seizure":[184],"event.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}