{"id":"https://openalex.org/W4295426734","doi":"https://doi.org/10.1109/embc48229.2022.9871000","title":"Causal Symbolic Information Transfer for the Assessment of functional Brain-Heart Interplay through EEG Microstates Occurrences: a proof-of-concept study","display_name":"Causal Symbolic Information Transfer for the Assessment of functional Brain-Heart Interplay through EEG Microstates Occurrences: a proof-of-concept study","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4295426734","doi":"https://doi.org/10.1109/embc48229.2022.9871000","pmid":"https://pubmed.ncbi.nlm.nih.gov/36086149"},"language":"en","primary_location":{"id":"doi:10.1109/embc48229.2022.9871000","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871000","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079173922","display_name":"Davide Manzoni","orcid":null},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I1300504238","display_name":"Piaggio (Italy)","ror":"https://ror.org/00r254y42","country_code":"IT","type":"company","lineage":["https://openalex.org/I1300504238"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Davide Manzoni","raw_affiliation_strings":["School of Engineering, University of Pisa,NeuroCardiovascular Intelligence lab,Bioengineering and Robotics Research Center E. Piaggio & Department of Information Engineering,Pisa,Italy"],"affiliations":[{"raw_affiliation_string":"School of Engineering, University of Pisa,NeuroCardiovascular Intelligence lab,Bioengineering and Robotics Research Center E. Piaggio & Department of Information Engineering,Pisa,Italy","institution_ids":["https://openalex.org/I1300504238","https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013014934","display_name":"Vincenzo Catrambone","orcid":"https://orcid.org/0000-0001-9030-7601"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I1300504238","display_name":"Piaggio (Italy)","ror":"https://ror.org/00r254y42","country_code":"IT","type":"company","lineage":["https://openalex.org/I1300504238"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Catrambone","raw_affiliation_strings":["School of Engineering, University of Pisa,NeuroCardiovascular Intelligence lab,Bioengineering and Robotics Research Center E. Piaggio & Department of Information Engineering,Pisa,Italy"],"affiliations":[{"raw_affiliation_string":"School of Engineering, University of Pisa,NeuroCardiovascular Intelligence lab,Bioengineering and Robotics Research Center E. Piaggio & Department of Information Engineering,Pisa,Italy","institution_ids":["https://openalex.org/I1300504238","https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041459422","display_name":"Gaetano Valenza","orcid":"https://orcid.org/0000-0001-6574-1879"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I1300504238","display_name":"Piaggio (Italy)","ror":"https://ror.org/00r254y42","country_code":"IT","type":"company","lineage":["https://openalex.org/I1300504238"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaetano Valenza","raw_affiliation_strings":["School of Engineering, University of Pisa,NeuroCardiovascular Intelligence lab,Bioengineering and Robotics Research Center E. Piaggio & Department of Information Engineering,Pisa,Italy"],"affiliations":[{"raw_affiliation_string":"School of Engineering, University of Pisa,NeuroCardiovascular Intelligence lab,Bioengineering and Robotics Research Center E. Piaggio & Department of Information Engineering,Pisa,Italy","institution_ids":["https://openalex.org/I1300504238","https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079173922"],"corresponding_institution_ids":["https://openalex.org/I108290504","https://openalex.org/I1300504238"],"apc_list":null,"apc_paid":null,"fwci":0.2005,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.31748826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2022","issue":null,"first_page":"255","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.7857301831245422},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5167345404624939},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4945838153362274},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.49127811193466187},{"id":"https://openalex.org/keywords/brain-activity-and-meditation","display_name":"Brain activity and meditation","score":0.4904910922050476},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.4705814719200134},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3871428370475769},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.33655333518981934},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.18016916513442993}],"concepts":[{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.7857301831245422},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5167345404624939},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4945838153362274},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.49127811193466187},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.4904910922050476},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.4705814719200134},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3871428370475769},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33655333518981934},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18016916513442993},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc48229.2022.9871000","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc48229.2022.9871000","pdf_url":null,"source":{"id":"https://openalex.org/S4363607706","display_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:36086149","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36086149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:arpi.unipi.it:11568/1156362","is_oa":false,"landing_page_url":"https://hdl.handle.net/11568/1156362","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1607198972","https://openalex.org/W1965555277","https://openalex.org/W2004522297","https://openalex.org/W2012462205","https://openalex.org/W2041782669","https://openalex.org/W2045412058","https://openalex.org/W2057569029","https://openalex.org/W2090764388","https://openalex.org/W2106873519","https://openalex.org/W2152287997","https://openalex.org/W2162134198","https://openalex.org/W2333032581","https://openalex.org/W2772704314","https://openalex.org/W2795079518","https://openalex.org/W2910134385","https://openalex.org/W2940246131","https://openalex.org/W2958541350","https://openalex.org/W2964836530","https://openalex.org/W3012088083","https://openalex.org/W3033307588","https://openalex.org/W3128209380","https://openalex.org/W3143949375","https://openalex.org/W3153187388","https://openalex.org/W3179585071","https://openalex.org/W3201506798","https://openalex.org/W3211265939","https://openalex.org/W6749512619"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2033914206","https://openalex.org/W2146076056","https://openalex.org/W2163831990","https://openalex.org/W3003836766","https://openalex.org/W2046077695","https://openalex.org/W2542552744","https://openalex.org/W2045882740","https://openalex.org/W1974369926"],"abstract_inverted_index":{"Electroencephalography":[0],"(EEG)":[1],"microstates":[2,41,98],"analysis":[3],"provides":[4],"a":[5,23,57,67,71,80,126,133,137,175],"sequence":[6],"of":[7,87,95],"topographies":[8],"representing":[9],"the":[10,46,62,85,92,143,146,156,163],"scalp-related":[11],"electric":[12],"field":[13],"over":[14],"time,":[15],"and":[16,99,115,136],"each":[17],"microstate":[18],"is":[19,108,121],"synthetically":[20],"represented":[21],"by":[22],"symbol.":[24],"Despite":[25],"recent":[26],"advances":[27],"on":[28,125,171],"functional":[29,88],"brain-heart":[30,172],"interplay":[31],"(BHI)":[32],"assessment,":[33],"to":[34,44,56],"our":[35],"knowledge":[36],"no":[37],"methodology":[38,120],"takes":[39],"EEG":[40,97],"into":[42],"account":[43],"relate":[45],"causal":[47],"heartbeat":[48],"dynamics.":[49],"Moreover,":[50],"standard":[51],"BHI":[52,89,106],"methods":[53],"are":[54],"tailored":[55],"single":[58],"EEG-channel":[59],"analysis,":[60],"neglecting":[61],"comprehensive":[63],"information":[64],"associated":[65],"with":[66],"multichannel":[68],"cluster":[69],"or":[70],"whole-brain":[72,176],"activity.":[73],"To":[74],"overcome":[75],"these":[76],"limitations,":[77],"we":[78],"devised":[79],"novel":[81,169],"methodological":[82],"frame-work":[83,165],"for":[84,142],"assessment":[86],"that":[90,162],"exploits":[91],"symbolic":[93,177],"representation":[94],"both":[96],"heart":[100],"rate":[101],"variability":[102],"(HRV)":[103],"series.":[104],"Directional":[105],"quantification":[107],"then":[109],"performed":[110],"through":[111,174],"Kullback-Leibler":[112],"Divergence":[113],"(KLD)":[114],"Transfer":[116],"Entropy.":[117],"The":[118],"proposed":[119,164],"here":[122],"preliminarily":[123],"tested":[124],"dataset":[127],"gathered":[128],"from":[129],"healthy":[130],"subjects":[131],"undergoing":[132],"resting":[134],"state":[135],"mental":[138],"arithmetic":[139],"task.":[140],"Except":[141],"KLD":[144],"in":[145],"from-brain-to-heart":[147],"direction,":[148],"all":[149],"other":[150],"estimates":[151],"showed":[152],"significant":[153],"differences":[154],"between":[155],"two":[157],"experimental":[158],"conditions.":[159],"We":[160],"conclude":[161],"may":[166],"promisingly":[167],"provide":[168],"insights":[170],"phenomena":[173],"representation.":[178]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}