{"id":"https://openalex.org/W4200140422","doi":"https://doi.org/10.1109/embc46164.2021.9630776","title":"Detection of MGMT methylation status using a Lab-on-Chip compatible isothermal amplification method","display_name":"Detection of MGMT methylation status using a Lab-on-Chip compatible isothermal amplification method","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W4200140422","doi":"https://doi.org/10.1109/embc46164.2021.9630776","pmid":"https://pubmed.ncbi.nlm.nih.gov/34892804"},"language":"en","primary_location":{"id":"doi:10.1109/embc46164.2021.9630776","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9630776","pdf_url":"https://ieeexplore.ieee.org/ielx7/9629355/9629471/09630776.pdf","source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/9629355/9629471/09630776.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081054899","display_name":"Myesha Jahin","orcid":null},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Myesha Jahin","raw_affiliation_strings":["Centre for Bio-Inspired Technology, Imperial College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Inspired Technology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009187445","display_name":"Benji Fenech\u2010Salerno","orcid":"https://orcid.org/0000-0002-0150-9672"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benji Fenech-Salerno","raw_affiliation_strings":["Centre for Bio-Inspired Technology, Imperial College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Inspired Technology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054027777","display_name":"Nicolas Moser","orcid":"https://orcid.org/0000-0002-6689-0486"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicolas Moser","raw_affiliation_strings":["Centre for Bio-Inspired Technology, Imperial College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Inspired Technology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069244062","display_name":"Pantelis Georgiou","orcid":"https://orcid.org/0000-0003-2476-3857"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pantelis Georgiou","raw_affiliation_strings":["Centre for Bio-Inspired Technology, Imperial College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Inspired Technology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028236133","display_name":"James M. Flanagan","orcid":"https://orcid.org/0000-0003-4955-1383"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Flanagan","raw_affiliation_strings":["Institute of Reproductive and Developmental Biology, Imperial College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive and Developmental Biology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038289380","display_name":"C. Toumazou","orcid":null},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Toumazou","raw_affiliation_strings":["Centre for Bio-Inspired Technology, Imperial College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Inspired Technology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022367518","display_name":"Sara de Mateo","orcid":"https://orcid.org/0000-0003-4754-6599"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sara De Mateo","raw_affiliation_strings":["Centre for Bio-Inspired Technology, Imperial College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Inspired Technology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013265768","display_name":"Melpomeni Kalofonou","orcid":"https://orcid.org/0000-0001-8299-4106"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Melpomeni Kalofonou","raw_affiliation_strings":["Centre for Bio-Inspired Technology, Imperial College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Inspired Technology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":1.5406,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.80881978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"13","issue":null,"first_page":"7385","last_page":"7389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9837999939918518,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9837999939918518,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9836000204086304,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loop-mediated-isothermal-amplification","display_name":"Loop-mediated isothermal amplification","score":0.7765852212905884},{"id":"https://openalex.org/keywords/isothermal-process","display_name":"Isothermal process","score":0.6050827503204346},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"Lab-on-a-chip","score":0.5657973885536194},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.5002079010009766},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.47679686546325684},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3882347345352173},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3763800263404846},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33914095163345337},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.18591412901878357},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.18248683214187622},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.17638030648231506},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.1471310257911682},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12742888927459717},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.08655217289924622},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08403673768043518}],"concepts":[{"id":"https://openalex.org/C60635243","wikidata":"https://www.wikidata.org/wiki/Q6675780","display_name":"Loop-mediated isothermal amplification","level":3,"score":0.7765852212905884},{"id":"https://openalex.org/C133347239","wikidata":"https://www.wikidata.org/wiki/Q486921","display_name":"Isothermal process","level":2,"score":0.6050827503204346},{"id":"https://openalex.org/C138942068","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Lab-on-a-chip","level":3,"score":0.5657973885536194},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5002079010009766},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.47679686546325684},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3882347345352173},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3763800263404846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33914095163345337},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18591412901878357},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.18248683214187622},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.17638030648231506},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.1471310257911682},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12742888927459717},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.08655217289924622},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08403673768043518},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc46164.2021.9630776","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9630776","pdf_url":"https://ieeexplore.ieee.org/ielx7/9629355/9629471/09630776.pdf","source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:34892804","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34892804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":{"id":"doi:10.1109/embc46164.2021.9630776","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9630776","pdf_url":"https://ieeexplore.ieee.org/ielx7/9629355/9629471/09630776.pdf","source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200140422.pdf","grobid_xml":"https://content.openalex.org/works/W4200140422.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1965301144","https://openalex.org/W1988878254","https://openalex.org/W2035021866","https://openalex.org/W2054179662","https://openalex.org/W2063839904","https://openalex.org/W2083021548","https://openalex.org/W2105275554","https://openalex.org/W2106680700","https://openalex.org/W2131981377","https://openalex.org/W2138417195","https://openalex.org/W2147977885","https://openalex.org/W2510749076","https://openalex.org/W2773338743","https://openalex.org/W2791995217","https://openalex.org/W2801058627","https://openalex.org/W2883923871","https://openalex.org/W3011064533","https://openalex.org/W3047623879","https://openalex.org/W3120630492","https://openalex.org/W3173311735","https://openalex.org/W6681984629"],"related_works":["https://openalex.org/W2385043201","https://openalex.org/W2378351399","https://openalex.org/W2945075252","https://openalex.org/W2003087030","https://openalex.org/W2390156094","https://openalex.org/W2376505109","https://openalex.org/W2136854845","https://openalex.org/W2375007538","https://openalex.org/W2387172946","https://openalex.org/W2569660137"],"abstract_inverted_index":{"The":[0,21],"growing":[1],"cancer":[2],"burden":[3],"necessitates":[4],"the":[5,35,80,103,112,130,133,137,153],"development":[6],"of":[7,23,39,73,77,117,124,139,158],"cost-effective":[8],"solutions":[9],"that":[10,111],"provide":[11],"rapid,":[12],"precise":[13],"and":[14,37,83],"personalised":[15],"information":[16],"to":[17,27,67,85,99,102,135,161],"improve":[18],"patient":[19],"outcome.":[20],"aim":[22],"this":[24,159],"study":[25],"was":[26,65,146],"develop":[28],"a":[29,44,55,149,166],"novel,":[30],"Lab-on-Chip":[31,59,150],"compatible":[32,60],"method":[33,63],"for":[34,42,48,71,155],"detection":[36,72],"quantification":[38],"DNA":[40,122,140,145],"methylation":[41,141],"MGMT,":[43,78],"well-established":[45],"molecular":[46],"biomarker":[47],"glioblastoma,":[49],"with":[50,79],"direct":[51],"clinical":[52],"translation":[53],"as":[54],"predictive":[56],"target.":[57],"A":[58],"isothermal":[61],"amplification":[62,113],"(LAMP)":[64],"used":[66],"test":[68],"its":[69],"efficacy":[70],"sequence-specific":[74],"methylated":[75,105],"regions":[76],"method's":[81],"specificity":[82],"sensitivity":[84,108],"have":[86],"been":[87],"compared":[88],"against":[89],"gold-standards":[90],"(MethyLight,":[91],"JumpStart).":[92],"Our":[93],"LAMP":[94],"primer":[95],"combinations":[96],"were":[97,115],"shown":[98],"be":[100],"specific":[101],"MGMT":[104],"region,":[106],"while":[107],"assays":[109],"determined":[110],"methods":[114],"capable":[116],"running":[118],"at":[119],"clinically":[120],"relevant":[121],"concentrations":[123],"0.2":[125],"-":[126],"20":[127],"ng/\u00b5L.":[128],"For":[129],"first":[131],"time,":[132],"ability":[134],"detect":[136],"presence":[138],"on":[142,148],"bisulfite":[143],"converted":[144],"demonstrated":[147],"setup,":[151],"laying":[152],"foundation":[154],"future":[156],"applications":[157],"platform":[160],"other":[162],"epigenetic":[163],"biomarkers":[164],"in":[165],"point-of-care":[167],"setting.":[168]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}