{"id":"https://openalex.org/W4200013961","doi":"https://doi.org/10.1109/embc46164.2021.9630725","title":"Design of Experiments and Sobol\u2019 sensitivity analysis of a hippocampus computational model","display_name":"Design of Experiments and Sobol\u2019 sensitivity analysis of a hippocampus computational model","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W4200013961","doi":"https://doi.org/10.1109/embc46164.2021.9630725","pmid":"https://pubmed.ncbi.nlm.nih.gov/34892519"},"language":"en","primary_location":{"id":"doi:10.1109/embc46164.2021.9630725","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9630725","pdf_url":null,"source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004379832","display_name":"Am\u00e9lie Aussel","orcid":"https://orcid.org/0000-0003-0498-2905"},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I4210110792","display_name":"Centre de Recherche en Automatique de Nancy","ror":"https://ror.org/022r5hc56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I4210099203","https://openalex.org/I4210100260","https://openalex.org/I4210110792","https://openalex.org/I4210159245","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I4210121838","display_name":"Laboratoire Lorrain de Recherche en Informatique et ses Applications","ror":"https://ror.org/02vnf0c38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I277688954","https://openalex.org/I4210107720","https://openalex.org/I4210121838","https://openalex.org/I4210159245","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Amelie Aussel","raw_affiliation_strings":["Centre de Recherche en Automatique de Nancy (CRAN UMR 7039), University of Lorraine-CNRS","Laboratoire Lorrain de Recherche en Informatique et ses applications (LORIA UMR 7503), University of Lorraine-INRIA-CNRS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Automatique de Nancy (CRAN UMR 7039), University of Lorraine-CNRS","institution_ids":["https://openalex.org/I4210110792","https://openalex.org/I90183372"]},{"raw_affiliation_string":"Laboratoire Lorrain de Recherche en Informatique et ses applications (LORIA UMR 7503), University of Lorraine-INRIA-CNRS","institution_ids":["https://openalex.org/I4210121838","https://openalex.org/I90183372","https://openalex.org/I1326498283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023628129","display_name":"Laure Buhry","orcid":"https://orcid.org/0000-0003-2401-5453"},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I4210121838","display_name":"Laboratoire Lorrain de Recherche en Informatique et ses Applications","ror":"https://ror.org/02vnf0c38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I277688954","https://openalex.org/I4210107720","https://openalex.org/I4210121838","https://openalex.org/I4210159245","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laure Buhry","raw_affiliation_strings":["Laboratoire Lorrain de Recherche en Informatique et ses applications (LORIA UMR 7503), University of Lorraine-INRIA-CNRS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Lorrain de Recherche en Informatique et ses applications (LORIA UMR 7503), University of Lorraine-INRIA-CNRS","institution_ids":["https://openalex.org/I4210121838","https://openalex.org/I90183372","https://openalex.org/I1326498283"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053716055","display_name":"Radu Ranta","orcid":"https://orcid.org/0000-0002-0893-8998"},"institutions":[{"id":"https://openalex.org/I4210110792","display_name":"Centre de Recherche en Automatique de Nancy","ror":"https://ror.org/022r5hc56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I4210099203","https://openalex.org/I4210100260","https://openalex.org/I4210110792","https://openalex.org/I4210159245","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Radu Ranta","raw_affiliation_strings":["Centre de Recherche en Automatique de Nancy (CRAN UMR 7039), University of Lorraine-CNRS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Automatique de Nancy (CRAN UMR 7039), University of Lorraine-CNRS","institution_ids":["https://openalex.org/I4210110792","https://openalex.org/I90183372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4921,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4516129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2021","issue":null,"first_page":"6146","last_page":"6150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sobol-sequence","display_name":"Sobol sequence","score":0.8027602434158325},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.6408417820930481},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.6012865304946899},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5929198265075684},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5733028650283813},{"id":"https://openalex.org/keywords/wakefulness","display_name":"Wakefulness","score":0.5024762153625488},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.34578949213027954},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3245934545993805},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3081522583961487},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.20496979355812073},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.10513350367546082},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.08641317486763}],"concepts":[{"id":"https://openalex.org/C49740808","wikidata":"https://www.wikidata.org/wiki/Q7550116","display_name":"Sobol sequence","level":3,"score":0.8027602434158325},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.6408417820930481},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6012865304946899},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5929198265075684},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5733028650283813},{"id":"https://openalex.org/C2779320081","wikidata":"https://www.wikidata.org/wiki/Q246710","display_name":"Wakefulness","level":3,"score":0.5024762153625488},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.34578949213027954},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3245934545993805},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3081522583961487},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.20496979355812073},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.10513350367546082},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08641317486763}],"mesh":[{"descriptor_ui":"D000077310","descriptor_name":"Sleep, Slow-Wave","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077310","descriptor_name":"Sleep, Slow-Wave","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077310","descriptor_name":"Sleep, Slow-Wave","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc46164.2021.9630725","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9630725","pdf_url":null,"source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:34892519","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34892519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W100464641","https://openalex.org/W1770958704","https://openalex.org/W1999331755","https://openalex.org/W2101589741","https://openalex.org/W2127411502","https://openalex.org/W2138623500","https://openalex.org/W2162870648","https://openalex.org/W2200681203","https://openalex.org/W2899103095","https://openalex.org/W6621148490"],"related_works":["https://openalex.org/W2965112349","https://openalex.org/W2382989764","https://openalex.org/W2963358185","https://openalex.org/W4302374767","https://openalex.org/W2118457152","https://openalex.org/W4237006455","https://openalex.org/W4214847409","https://openalex.org/W1991366063","https://openalex.org/W4283798112","https://openalex.org/W4300026339"],"abstract_inverted_index":{"The":[0,89],"hippocampus":[1,68],"is":[2,86,95],"a":[3,44,47],"brain":[4],"area":[5],"involved":[6],"in":[7,17,43],"many":[8],"memory":[9],"processes.":[10],"This":[11],"structure":[12],"can":[13],"also":[14],"be":[15],"affected":[16],"neurological":[18],"diseases":[19],"such":[20],"as":[21],"mesial":[22],"temporal":[23],"lobe":[24],"epilepsy.":[25],"A":[26],"better":[27],"understanding":[28],"of":[29,53,65,83,91,105,119],"its":[30,87],"electrophysiological":[31],"activity":[32],"could":[33],"benefit":[34],"both":[35],"the":[36,61,66,92,106,117,122],"neuroscientific":[37,98],"and":[38,72,100,121],"clinical":[39],"communities.":[40],"We":[41],"proposed,":[42],"previous":[45],"paper,":[46],"detailed":[48],"bio-realistic":[49],"conductance-based":[50],"mathematical":[51],"model":[52,85],"more":[54],"than":[55],"thirty":[56],"thousand":[57],"neurons":[58],"to":[59,76,96],"reproduce":[60],"main":[62],"oscillatory":[63],"features":[64],"healthy":[67],"during":[69],"slow-wave":[70],"sleep":[71],"wakefulness,":[73],"from":[74],"slow":[75],"very":[77],"fast":[78],"frequencies.":[79],"One":[80],"big":[81],"challenge":[82],"this":[84],"parametrization.":[88],"aim":[90],"present":[93],"work":[94],"combine":[97],"expertise":[99],"systematic":[101],"yet":[102],"efficient":[103],"exploration":[104],"highly":[107],"dimensional":[108],"parameter":[109],"space":[110],"using":[111],"well":[112],"defined":[113],"identification":[114],"methods,":[115],"namely":[116],"design":[118],"experiments":[120],"Sobol's":[123],"sensitivity":[124],"analysis.":[125]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
