{"id":"https://openalex.org/W4200012210","doi":"https://doi.org/10.1109/embc46164.2021.9630589","title":"Automating the Design of Cancer Specific DNA Probes Using Computational Algorithms","display_name":"Automating the Design of Cancer Specific DNA Probes Using Computational Algorithms","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W4200012210","doi":"https://doi.org/10.1109/embc46164.2021.9630589","pmid":"https://pubmed.ncbi.nlm.nih.gov/34891648"},"language":"en","primary_location":{"id":"doi:10.1109/embc46164.2021.9630589","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9630589","pdf_url":"https://ieeexplore.ieee.org/ielx7/9629355/9629471/09630589.pdf","source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/9629355/9629471/09630589.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100720452","display_name":"Jiacheng Zhang","orcid":"https://orcid.org/0000-0002-1895-5003"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jiacheng Zhang","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Imperial College London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088140371","display_name":"George Alexandrou","orcid":null},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"George Alexandrou","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Imperial College London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038289380","display_name":"C. Toumazou","orcid":null},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Toumazou","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Imperial College London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013265768","display_name":"Melpomeni Kalofonou","orcid":"https://orcid.org/0000-0001-8299-4106"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Melpomeni Kalofonou","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Imperial College London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, Centre for Bio-Inspired Technology, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100720452"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":0.5188,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52509294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2021","issue":null,"first_page":"1852","last_page":"1856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6205562353134155},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4514828622341156},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.32957756519317627},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.156174898147583}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6205562353134155},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4514828622341156},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32957756519317627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.156174898147583}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc46164.2021.9630589","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9630589","pdf_url":"https://ieeexplore.ieee.org/ielx7/9629355/9629471/09630589.pdf","source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:34891648","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34891648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":{"id":"doi:10.1109/embc46164.2021.9630589","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9630589","pdf_url":"https://ieeexplore.ieee.org/ielx7/9629355/9629471/09630589.pdf","source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200012210.pdf","grobid_xml":"https://content.openalex.org/works/W4200012210.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1502872322","https://openalex.org/W2009095852","https://openalex.org/W2026300665","https://openalex.org/W2054179662","https://openalex.org/W2063839904","https://openalex.org/W2065098811","https://openalex.org/W2105275554","https://openalex.org/W2164604555","https://openalex.org/W2347160271","https://openalex.org/W2467093478","https://openalex.org/W2807664264","https://openalex.org/W2883923871","https://openalex.org/W2889646458","https://openalex.org/W2889665799","https://openalex.org/W2917102036","https://openalex.org/W3011064533","https://openalex.org/W3037977609","https://openalex.org/W3039885051","https://openalex.org/W3089581278","https://openalex.org/W3089698634","https://openalex.org/W3173311735","https://openalex.org/W6629932431","https://openalex.org/W6783931504"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2051487156","https://openalex.org/W2073681303","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"This":[0],"paper":[1],"introduces":[2],"a":[3,50,63,72,109,123],"novel":[4],"Python":[5],"script":[6,40,60,80],"which":[7],"automates":[8],"the":[9,19,31,35,39,85,98,103],"design":[10,76,113],"process":[11],"of":[12,30,43,65,88,137],"cancer":[13,94],"variant-specific":[14,138],"DNA":[15,32],"probes,":[16],"based":[17],"on":[18],"amplification":[20],"method":[21,125],"LAMP":[22,111,116],"(Loop-Mediated":[23],"Isothermal":[24],"Amplification).":[25],"With":[26],"just":[27],"an":[28,55],"input":[29],"sequence":[33],"and":[34,91],"mutation":[36],"base":[37],"location,":[38],"outputs":[41],"suggestions":[42],"two":[44],"best":[45],"fitting":[46],"primer":[47,75,106,112],"sets":[48],"for":[49,74,126],"given":[51],"target,":[52],"together":[53],"with":[54,97],"estimated":[56],"working":[57],"efficiency.":[58],"The":[59,78],"also":[61],"implements":[62],"feature":[64],"'script":[66],"training',":[67],"using":[68,84],"experimentally-validated":[69],"primers":[70],"as":[71,122],"benchmark":[73],"optimisation.":[77],"proposed":[79],"has":[81],"been":[82],"tested":[83],"gene":[86],"sequences":[87],"ESR1":[89,92],"p.E380Q":[90],"p.Y537S":[93],"specific":[95],"mutations,":[96],"results":[99],"to":[100,117,133],"closely":[101],"resemble":[102],"experimentally":[104],"validated":[105],"sets.":[107],"Creating":[108],"rapid":[110],"utility":[114],"allows":[115],"be":[118],"more":[119],"easily":[120],"used":[121],"molecular":[124],"assay":[127],"development":[128],"in":[129],"Lab-on-Chip":[130],"(LoC)":[131],"systems":[132],"track":[134],"mutational":[135],"profiles":[136],"assays.":[139]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}