{"id":"https://openalex.org/W4200211835","doi":"https://doi.org/10.1109/embc46164.2021.9630158","title":"Adaptive Individualized Drug-Dose Response Modeling from a Limited Clinical Data: Case of Warfarin Management","display_name":"Adaptive Individualized Drug-Dose Response Modeling from a Limited Clinical Data: Case of Warfarin Management","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W4200211835","doi":"https://doi.org/10.1109/embc46164.2021.9630158","pmid":"https://pubmed.ncbi.nlm.nih.gov/34892207"},"language":"en","primary_location":{"id":"doi:10.1109/embc46164.2021.9630158","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9630158","pdf_url":null,"source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Affan Affan","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Affan Affan","raw_affiliation_strings":["University of Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jacek M. Zurada","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacek M. Zurada","raw_affiliation_strings":["University of Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael E. Brier","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I4210111273","display_name":"Louisville VA Medical Center","ror":"https://ror.org/01zd7yk57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111273","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Brier","raw_affiliation_strings":["Robley Rex Veterans Administration Medical Center, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robley Rex Veterans Administration Medical Center, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786","https://openalex.org/I4210111273"]}]},{"author_position":"last","author":{"id":null,"display_name":"Tamer Inanc","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamer Inanc","raw_affiliation_strings":["University of Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2021","issue":null,"first_page":"4448","last_page":"4451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.18240000307559967,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.18240000307559967,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1264999955892563,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.12110000103712082,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.525600016117096},{"id":"https://openalex.org/keywords/warfarin","display_name":"Warfarin","score":0.453000009059906},{"id":"https://openalex.org/keywords/predictability","display_name":"Predictability","score":0.4415000081062317},{"id":"https://openalex.org/keywords/limiting","display_name":"Limiting","score":0.4375},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.4260999858379364},{"id":"https://openalex.org/keywords/usability","display_name":"Usability","score":0.4203999936580658},{"id":"https://openalex.org/keywords/drug-administration","display_name":"Drug administration","score":0.38659998774528503}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.525600016117096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48590001463890076},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4706999957561493},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.453000009059906},{"id":"https://openalex.org/C197640229","wikidata":"https://www.wikidata.org/wiki/Q2534066","display_name":"Predictability","level":2,"score":0.4415000081062317},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4375},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.4260999858379364},{"id":"https://openalex.org/C170130773","wikidata":"https://www.wikidata.org/wiki/Q216378","display_name":"Usability","level":2,"score":0.4203999936580658},{"id":"https://openalex.org/C2987276129","wikidata":"https://www.wikidata.org/wiki/Q12140","display_name":"Drug administration","level":2,"score":0.38659998774528503},{"id":"https://openalex.org/C107464732","wikidata":"https://www.wikidata.org/wiki/Q235781","display_name":"Adaptive control","level":3,"score":0.3756999969482422},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.33469998836517334},{"id":"https://openalex.org/C91575142","wikidata":"https://www.wikidata.org/wiki/Q1971426","display_name":"Optimal control","level":2,"score":0.33219999074935913},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.31049999594688416},{"id":"https://openalex.org/C119247159","wikidata":"https://www.wikidata.org/wiki/Q1366192","display_name":"System identification","level":3,"score":0.29429998993873596},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.2502000033855438}],"mesh":[{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc46164.2021.9630158","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9630158","pdf_url":null,"source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:34892207","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34892207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2018954315","https://openalex.org/W2047270732","https://openalex.org/W2056370385","https://openalex.org/W2124955418","https://openalex.org/W2126885419","https://openalex.org/W2155011318","https://openalex.org/W2279035215","https://openalex.org/W2280910116","https://openalex.org/W2589739019","https://openalex.org/W3108195191","https://openalex.org/W6601998390","https://openalex.org/W6638453670","https://openalex.org/W6656571560"],"related_works":[],"abstract_inverted_index":{"Administration":[0],"of":[1,24,50,64,103,131],"drugs":[2],"requires":[3],"sophisticated":[4],"methods":[5],"to":[6,41,55,91,152],"determine":[7,56],"the":[8,22,35,47,62,73,84,93],"drug":[9,58,144],"quantity":[10],"for":[11,21,67,121,142],"optimal":[12,57],"results,":[13],"and":[14,70,97,148],"it":[15],"has":[16],"been":[17],"a":[18,81,118,128,155],"challenging":[19],"task":[20],"number":[23,49,130],"diseases.":[25],"To":[26,60],"solve":[27],"these":[28,65],"challenges,":[29],"in":[30,140],"this":[31],"paper,":[32],"we":[33],"present":[34],"semi-blind":[36,94],"robust":[37,95],"model":[38,74,98],"identification":[39,96],"technique":[40,76],"find":[42],"individualized":[43,123],"patient":[44,146,150],"models":[45,66,104,126],"using":[46],"minimum":[48,109],"clinically":[51],"acquired":[52],"patient-specific":[53,133],"data":[54],"dosage.":[59],"ensure":[61],"usability":[63],"dosage":[68],"predictability":[69],"controller":[71],"design,":[72],"(In)validation":[75,99],"is":[77,105],"also":[78],"investigated.":[79],"As":[80],"case":[82],"study,":[83],"patients":[85],"treated":[86],"with":[87,154],"warfarin":[88],"are":[89],"studied":[90],"demonstrate":[92],"techniques.":[100],"The":[101],"performance":[102],"assessed":[106],"by":[107],"calculating":[108],"means":[110],"squared":[111],"error":[112],"(MMSE).Clinical":[113],"Relevance-":[114],"This":[115,135],"work":[116,136],"establishes":[117],"general":[119],"framework":[120],"adaptive":[122],"drug-dose":[124],"response":[125],"from":[127],"limited":[129],"clinical":[132],"data.":[134],"will":[137],"help":[138],"clinicians":[139],"decision-making":[141],"improved":[143],"dosing,":[145],"care,":[147],"limiting":[149],"exposure":[151],"agents":[153],"narrow":[156],"therapeutic":[157],"range.":[158]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2021-12-31T00:00:00"}
