{"id":"https://openalex.org/W4200335619","doi":"https://doi.org/10.1109/embc46164.2021.9629924","title":"Time-varying Spectral Index of Electrodermal Activity to Predict Central Nervous System Oxygen Toxicity Symptoms in Divers: Preliminary results","display_name":"Time-varying Spectral Index of Electrodermal Activity to Predict Central Nervous System Oxygen Toxicity Symptoms in Divers: Preliminary results","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W4200335619","doi":"https://doi.org/10.1109/embc46164.2021.9629924","pmid":"https://pubmed.ncbi.nlm.nih.gov/34891512"},"language":"en","primary_location":{"id":"doi:10.1109/embc46164.2021.9629924","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9629924","pdf_url":null,"source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hugo F. Posada-Quintero","orcid":null},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hugo F. Posada-Quintero","raw_affiliation_strings":["Biomedical Engineering Department, University of Connecticut, Storrs, CT, USA"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, University of Connecticut, Storrs, CT, USA","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bruce J. Derrick","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce J. Derrick","raw_affiliation_strings":["Department of Anesthesiology, Division of Emergency Medicine, Duke University, Durham, NC, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Division of Emergency Medicine, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher Winstead-Derlega","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Winstead-Derlega","raw_affiliation_strings":["Department of Anesthesiology, Division of Emergency Medicine, Duke University, Durham, NC, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Division of Emergency Medicine, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sara I. Gonzalez","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara I. Gonzalez","raw_affiliation_strings":["Division of Emergency Medicine, Duke University, Durham, NC, USA"],"affiliations":[{"raw_affiliation_string":"Division of Emergency Medicine, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Claire Ellis","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Claire Ellis","raw_affiliation_strings":["Division of Emergency Medicine, Duke University, Durham, NC, USA"],"affiliations":[{"raw_affiliation_string":"Division of Emergency Medicine, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John J. Freiberger","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Freiberger","raw_affiliation_strings":["Department of Anesthesiology, Duke University, Durham, NC, USA"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ki H. Chon","orcid":null},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ki H. Chon","raw_affiliation_strings":["Biomedical Engineering Department, University of Connecticut, Storrs, CT, USA"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, University of Connecticut, Storrs, CT, USA","institution_ids":["https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I140172145"],"apc_list":null,"apc_paid":null,"fwci":2.4192,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.89805825,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"2021","issue":null,"first_page":"1242","last_page":"1245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.7210999727249146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.7210999727249146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.6011000275611877},{"id":"https://openalex.org/keywords/breathing","display_name":"Breathing","score":0.5719000101089478},{"id":"https://openalex.org/keywords/hyperbaric-oxygen","display_name":"Hyperbaric oxygen","score":0.5716000199317932},{"id":"https://openalex.org/keywords/spectral-analysis","display_name":"Spectral analysis","score":0.5070000290870667},{"id":"https://openalex.org/keywords/decompression-sickness","display_name":"Decompression sickness","score":0.49900001287460327},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.4390999972820282},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.41100001335144043},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"Sympathetic nervous system","score":0.37470000982284546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6402999758720398},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6093999743461609},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6011000275611877},{"id":"https://openalex.org/C39300077","wikidata":"https://www.wikidata.org/wiki/Q9530","display_name":"Breathing","level":2,"score":0.5719000101089478},{"id":"https://openalex.org/C2994405533","wikidata":"https://www.wikidata.org/wiki/Q731615","display_name":"Hyperbaric oxygen","level":2,"score":0.5716000199317932},{"id":"https://openalex.org/C2983668108","wikidata":"https://www.wikidata.org/wiki/Q280453","display_name":"Spectral analysis","level":3,"score":0.5070000290870667},{"id":"https://openalex.org/C2776957369","wikidata":"https://www.wikidata.org/wiki/Q460591","display_name":"Decompression sickness","level":3,"score":0.49900001287460327},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4390999972820282},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.41100001335144043},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.37470000982284546},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.37310001254081726},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.3555000126361847},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.35100001096725464},{"id":"https://openalex.org/C2777590204","wikidata":"https://www.wikidata.org/wiki/Q125223","display_name":"Oxygen toxicity","level":3,"score":0.3458000123500824},{"id":"https://openalex.org/C2778615406","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Amnesia","level":2,"score":0.3050999939441681},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2964000105857849},{"id":"https://openalex.org/C3020789104","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic activity","level":4,"score":0.2825999855995178},{"id":"https://openalex.org/C3018260909","wikidata":"https://www.wikidata.org/wiki/Q1322871","display_name":"Exploratory analysis","level":2,"score":0.2802000045776367},{"id":"https://openalex.org/C2780930544","wikidata":"https://www.wikidata.org/wiki/Q62962","display_name":"Hypnotic","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C20463939","wikidata":"https://www.wikidata.org/wiki/Q811123","display_name":"Diaphragmatic breathing","level":3,"score":0.2685999870300293},{"id":"https://openalex.org/C2779480328","wikidata":"https://www.wikidata.org/wiki/Q1183684","display_name":"Decompression","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25949999690055847},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.25589999556541443},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.2556999921798706}],"mesh":[{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005712","descriptor_name":"Galvanic Skin Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005712","descriptor_name":"Galvanic Skin Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005712","descriptor_name":"Galvanic Skin Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc46164.2021.9629924","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9629924","pdf_url":null,"source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:34891512","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34891512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W122741093","https://openalex.org/W308542233","https://openalex.org/W638997142","https://openalex.org/W1987253690","https://openalex.org/W2031734932","https://openalex.org/W2042658424","https://openalex.org/W2060705482","https://openalex.org/W2062905783","https://openalex.org/W2065490412","https://openalex.org/W2108455549","https://openalex.org/W2110456938","https://openalex.org/W2127108471","https://openalex.org/W2140147284","https://openalex.org/W2167357446","https://openalex.org/W2329439512","https://openalex.org/W2504069552","https://openalex.org/W2764271683","https://openalex.org/W2905500182","https://openalex.org/W2913068231","https://openalex.org/W2970038897","https://openalex.org/W3009321689","https://openalex.org/W4240284349","https://openalex.org/W4242743388","https://openalex.org/W4255375128","https://openalex.org/W4300792138","https://openalex.org/W6601830604","https://openalex.org/W6604439782","https://openalex.org/W6605243319","https://openalex.org/W6605511707","https://openalex.org/W6608303526","https://openalex.org/W6634074731","https://openalex.org/W6642046472"],"related_works":[],"abstract_inverted_index":{"The":[0,123],"most":[1],"effective":[2],"method":[3,181],"to":[4,89,141,148,161,173,192,199],"mitigate":[5],"decompression":[6],"sickness":[7],"in":[8,58,70,121,129,187],"divers":[9,16],"is":[10],"hyperbaric":[11],"oxygen":[12,27,63,149],"(HBO<sub>2</sub>)":[13],"pre-breathing.":[14],"However,":[15],"breathing":[17],"HBO<sub>2</sub>":[18],"are":[19],"at":[20,61,75],"risk":[21],"for":[22,87,106,114],"developing":[23],"central":[24],"nervous":[25],"system":[26],"toxicity":[28],"(CNS-OT),":[29],"which":[30,170,182],"can":[31,171],"manifest":[32],"as":[33,103],"symptoms":[34,45,118,146,197],"that":[35],"might":[36,157],"impair":[37],"a":[38,83,104,178,184],"diver's":[39],"performance,":[40],"or":[41],"cause":[42],"more":[43],"serious":[44],"like":[46],"seizures.":[47],"In":[48],"this":[49],"study,":[50],"we":[51,93],"have":[52,94],"collected":[53],"electrodermal":[54,189],"activity":[55,190],"(EDA)":[56],"signals":[57],"fifteen":[59],"subjects":[60],"elevated":[62],"partial":[64],"pressures":[65],"(2.06":[66],"ATA,":[67],"35":[68],"FSW)":[69],"the":[71,76,96,115,130,159,165,188],"\"foxtrot\"":[72],"chamber":[73],"pool":[74],"Duke":[77],"University":[78],"Hyperbaric":[79],"Center,":[80],"while":[81],"performing":[82],"cognitive":[84],"stress":[85],"test":[86],"up":[88],"120":[90],"minutes.":[91],"Specifically,":[92],"computed":[95],"time-varying":[97],"spectral":[98],"analysis":[99,180],"of":[100,117,119,145,168,196],"EDA":[101,136],"(TVSymp)":[102],"tool":[105],"sympathetic":[107],"tone":[108],"assessment":[109],"and":[110],"evaluated":[111],"its":[112],"feasibility":[113],"prediction":[116],"CNS-OT":[120,169],"divers.":[122],"preliminary":[124],"results":[125],"show":[126],"large":[127],"increase":[128,186],"amplitude":[131],"TVSymp":[132,156],"values":[133],"derived":[134],"from":[135],"recordings":[137],"~2":[138],"minutes":[139],"prior":[140,191],"expert":[142,194],"human":[143,193],"adjudication":[144,195],"related":[147,198],"toxicity.":[150],"An":[151],"early":[152],"detection":[153],"based":[154],"on":[155],"allow":[158],"diver":[160],"take":[162],"countermeasures":[163],"against":[164],"dire":[166],"consequences":[167],"lead":[172],"drowning.Clinical":[174],"Relevance-This":[175],"study":[176],"provides":[177],"sensitive":[179],"indicates":[183],"significant":[185],"CNS-OT.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2021-12-31T00:00:00"}