{"id":"https://openalex.org/W4200011767","doi":"https://doi.org/10.1109/embc46164.2021.9629785","title":"Modeling the variability of insulin sensitivity during the menstrual cycle in women with type 1 diabetes to adjust open-loop insulin therapy","display_name":"Modeling the variability of insulin sensitivity during the menstrual cycle in women with type 1 diabetes to adjust open-loop insulin therapy","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W4200011767","doi":"https://doi.org/10.1109/embc46164.2021.9629785","pmid":"https://pubmed.ncbi.nlm.nih.gov/34891578"},"language":"en","primary_location":{"id":"doi:10.1109/embc46164.2021.9629785","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9629785","pdf_url":null,"source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087918897","display_name":"Jenny L. Diaz C.","orcid":"https://orcid.org/0000-0002-7863-4914"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jenny L. Diaz C.","raw_affiliation_strings":["Center for Diabetes Technology, University of Virginia, Charlottesville, VA, USA"],"affiliations":[{"raw_affiliation_string":"Center for Diabetes Technology, University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044457781","display_name":"Eda Cengiz","orcid":"https://orcid.org/0000-0001-7992-9506"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eda Cengiz","raw_affiliation_strings":["Division of Pediatric Endocrinology and Diabetes, Yale University School of Medicine, New Haven, CT, USA"],"affiliations":[{"raw_affiliation_string":"Division of Pediatric Endocrinology and Diabetes, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089437051","display_name":"Marc D. Breton","orcid":"https://orcid.org/0000-0001-7645-2693"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc D. Breton","raw_affiliation_strings":["Center for Diabetes Technology, University of Virginia, Charlottesville, VA, USA"],"affiliations":[{"raw_affiliation_string":"Center for Diabetes Technology, University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046374727","display_name":"Chiara Fabris","orcid":"https://orcid.org/0000-0001-7575-4622"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiara Fabris","raw_affiliation_strings":["Center for Diabetes Technology, University of Virginia, Charlottesville, VA, USA"],"affiliations":[{"raw_affiliation_string":"Center for Diabetes Technology, University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087918897"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":null,"apc_paid":null,"fwci":1.4336,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.77570093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"33","issue":null,"first_page":"1543","last_page":"1546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9830999970436096,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycemic","display_name":"Glycemic","score":0.8000354170799255},{"id":"https://openalex.org/keywords/menstrual-cycle","display_name":"Menstrual cycle","score":0.7983601093292236},{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.6690641641616821},{"id":"https://openalex.org/keywords/luteal-phase","display_name":"Luteal phase","score":0.6621979475021362},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"Type 1 diabetes","score":0.5938898921012878},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5815521478652954},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.5617703795433044},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"Insulin sensitivity","score":0.5227106809616089},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.48943081498146057},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.470878928899765},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4487728178501129},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"Insulin resistance","score":0.2803323268890381},{"id":"https://openalex.org/keywords/hormone","display_name":"Hormone","score":0.19443216919898987}],"concepts":[{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.8000354170799255},{"id":"https://openalex.org/C2779058012","wikidata":"https://www.wikidata.org/wiki/Q83864","display_name":"Menstrual cycle","level":3,"score":0.7983601093292236},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6690641641616821},{"id":"https://openalex.org/C143228043","wikidata":"https://www.wikidata.org/wiki/Q2363481","display_name":"Luteal phase","level":3,"score":0.6621979475021362},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5938898921012878},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5815521478652954},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5617703795433044},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.5227106809616089},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48943081498146057},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.470878928899765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4487728178501129},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.2803323268890381},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.19443216919898987}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008597","descriptor_name":"Menstrual Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008597","descriptor_name":"Menstrual Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008597","descriptor_name":"Menstrual Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc46164.2021.9629785","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9629785","pdf_url":null,"source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:34891578","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34891578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2043505835","https://openalex.org/W2113314534","https://openalex.org/W2410556865","https://openalex.org/W2750485813","https://openalex.org/W2790915589","https://openalex.org/W4241883936"],"related_works":["https://openalex.org/W2297547890","https://openalex.org/W2187310686","https://openalex.org/W2523260065","https://openalex.org/W2008367171","https://openalex.org/W1984675688","https://openalex.org/W2509239751","https://openalex.org/W2184261368","https://openalex.org/W2016668868","https://openalex.org/W4256169667","https://openalex.org/W2273787269"],"abstract_inverted_index":{"Women":[0],"with":[1],"type":[2],"1":[3],"diabetes":[4],"(T1D)":[5],"typically":[6],"experience":[7],"a":[8,46,126],"decrease":[9],"in":[10,58,87,129],"insulin":[11,34,80,123],"sensitivity":[12],"(SI)":[13],"during":[14],"the":[15,23,55,59,72,88,91,103],"second":[16],"half":[17],"of":[18,62,74,90],"their":[19],"menstrual":[20,56,75,92],"cycle":[21,57,76],"(or":[22],"luteal":[24],"phase":[25],"(LP)),":[26],"which":[27],"oftentimes":[28],"is":[29,117],"not":[30],"properly":[31],"addressed":[32],"by":[33],"therapy,":[35,124],"therefore":[36],"leading":[37],"to":[38,41,49,54,67,69,78],"increased":[39],"exposure":[40],"hyperglycemia.":[42],"This":[43],"study":[44],"proposes":[45],"suitable":[47],"way":[48],"model":[50],"SI":[51,115],"variability":[52,116],"due":[53],"FDA-accepted":[60],"University":[61],"Virginia":[63],"(UVA)/Padova":[64],"T1D":[65],"Simulator,":[66],"determine":[68],"what":[70],"extent":[71],"inclusion":[73],"information":[77],"fine-tune":[79],"therapy":[81],"could":[82],"help":[83],"improve":[84],"glycemic":[85],"control":[86],"LP":[89],"cycle.":[93],"In-silico":[94],"tests":[95],"were":[96],"performed":[97],"considering":[98],"different":[99],"simulation":[100],"scenarios,":[101],"and":[102],"obtained":[104],"results":[105],"show":[106],"that":[107],"hyperglycemic":[108],"excursions":[109],"can":[110],"be":[111],"largely":[112],"reduced":[113],"when":[114],"taken":[118],"into":[119],"account":[120],"for":[121],"planning":[122],"without":[125],"relevant":[127],"increase":[128],"hypoglycemic":[130],"events.":[131]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
