{"id":"https://openalex.org/W4200190540","doi":"https://doi.org/10.1109/embc46164.2021.9629501","title":"Influence of the perfusion bioreactor on Stratified and Distributed approaches for multilayered tissue engineering on biodegradable scaffolds","display_name":"Influence of the perfusion bioreactor on Stratified and Distributed approaches for multilayered tissue engineering on biodegradable scaffolds","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W4200190540","doi":"https://doi.org/10.1109/embc46164.2021.9629501","pmid":"https://pubmed.ncbi.nlm.nih.gov/34891498"},"language":"en","primary_location":{"id":"doi:10.1109/embc46164.2021.9629501","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9629501","pdf_url":null,"source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080206200","display_name":"Kazutomo Baba","orcid":null},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazutomo Baba","raw_affiliation_strings":["School of Systems and Information Engineering, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Systems and Information Engineering, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073187231","display_name":"Andrey Mikhailov","orcid":"https://orcid.org/0000-0003-3073-3005"},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Andrey Mikhailov","raw_affiliation_strings":["School of Systems and Information Engineering, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Systems and Information Engineering, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039658736","display_name":"Yoshiyuki Sankai","orcid":"https://orcid.org/0000-0002-6345-1541"},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyuki Sankai","raw_affiliation_strings":["School of Systems and Information Engineering, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Systems and Information Engineering, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I146399215"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.28828878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"2021","issue":null,"first_page":"1181","last_page":"1186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plga","display_name":"PLGA","score":0.8670617341995239},{"id":"https://openalex.org/keywords/scaffold","display_name":"Scaffold","score":0.8381558656692505},{"id":"https://openalex.org/keywords/bioreactor","display_name":"Bioreactor","score":0.7584657073020935},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.7359017133712769},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.7319952249526978},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5904746055603027},{"id":"https://openalex.org/keywords/degradation","display_name":"Degradation (telecommunications)","score":0.41025665402412415},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.29028451442718506},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.2780739367008209},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.15391206741333008},{"id":"https://openalex.org/keywords/nanoparticle","display_name":"Nanoparticle","score":0.07356330752372742},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.055171847343444824}],"concepts":[{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.8670617341995239},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.8381558656692505},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.7584657073020935},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.7359017133712769},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.7319952249526978},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5904746055603027},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.41025665402412415},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29028451442718506},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2780739367008209},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15391206741333008},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.07356330752372742},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.055171847343444824},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc46164.2021.9629501","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc46164.2021.9629501","pdf_url":null,"source":{"id":"https://openalex.org/S4363607750","display_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:34891498","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34891498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.6600000262260437}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2013417535","https://openalex.org/W2025033472","https://openalex.org/W2045333343","https://openalex.org/W2049435279","https://openalex.org/W2094214448","https://openalex.org/W2122180971","https://openalex.org/W2123766393","https://openalex.org/W2755780660","https://openalex.org/W2783464203","https://openalex.org/W2804845184","https://openalex.org/W2896478772","https://openalex.org/W2972260241","https://openalex.org/W2996426436","https://openalex.org/W3007661315","https://openalex.org/W3177871391"],"related_works":["https://openalex.org/W3003069570","https://openalex.org/W2412922490","https://openalex.org/W2626164717","https://openalex.org/W2387757681","https://openalex.org/W2478420051","https://openalex.org/W3196863326","https://openalex.org/W922543731","https://openalex.org/W1847492452","https://openalex.org/W2100993833","https://openalex.org/W4256095375"],"abstract_inverted_index":{"Despite":[0],"wide":[1],"use":[2],"and":[3,44,60,72,101,168,174],"approval":[4],"of":[5,49,68,74,153,177,183],"poly":[6],"lactic-coglycolic":[7],"acid":[8],"(PLGA)":[9],"for":[10],"surgical":[11],"applications,":[12],"there":[13],"have":[14],"been":[15],"very":[16],"few":[17],"studies":[18],"on":[19,90],"tissue":[20,32,62],"constructions":[21],"that":[22],"mimic":[23],"physiological":[24],"multilayer":[25,178],"structures":[26],"by":[27,88],"combining":[28],"PLGA":[29,76,117,154,184],"scaffolds":[30,185],"with":[31,109,120,180],"engineering.":[33],"In":[34,78,145],"our":[35],"study,":[36],"we":[37,54,102,114],"developed":[38],"a":[39,91],"bioreactor":[40,136,157],"system":[41],"to":[42,45,138],"maintain,":[43],"train":[46],"two":[47],"types":[48],"three-layered":[50],"vascular-like":[51],"structures.":[52],"Then":[53],"examined":[55],"how":[56],"the":[57,66,69,75,79,83,104,110,126,135,139,147,151,171],"perfusion":[58,158],"conditions":[59],"different":[61],"engineering":[63],"approaches":[64],"affected":[65],"formation":[67],"layered":[70],"structure":[71,179],"degradation":[73,130],"scaffolds.":[77],"proposed":[80],"Distributed":[81],"Method,":[82],"cells":[84],"were":[85],"seeded":[86,119],"layer":[87,89],"single":[92],"scaffold,":[93],"using":[94],"spheroids":[95],"bigger":[96],"than":[97],"scaffold":[98,129],"fiber":[99],"gaps":[100],"achieved":[103],"higher":[105],"cell":[106,123,166,172],"density":[107,173],"compared":[108,137],"Stratified":[111],"Method":[112],"where":[113],"stacked":[115],"three":[116],"sheets":[118],"individual":[121],"vascular":[122],"types.":[124],"At":[125],"histological":[127],"level,":[128],"was":[131],"more":[132],"prominent":[133],"in":[134,143],"same":[140],"time":[141],"interval":[142],"vivo.":[144],"addition,":[146],"faster":[148],"flow":[149,162],"accelerated":[150],"decomposition":[152],"fibers.":[155],"Moreover,":[156],"culture":[159],"at":[160],"lower":[161],"rates":[163],"could":[164],"balance":[165],"adhesion":[167],"survival,":[169],"improve":[170],"promote":[175],"self-organization":[176],"desirable":[181],"rate":[182],"degradation.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}