{"id":"https://openalex.org/W3081888830","doi":"https://doi.org/10.1109/embc44109.2020.9176845","title":"Electrical Stimulation of the Infraorbital Nerve Induces Diving Reflex in a Dose-Controlled Manner","display_name":"Electrical Stimulation of the Infraorbital Nerve Induces Diving Reflex in a Dose-Controlled Manner","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3081888830","doi":"https://doi.org/10.1109/embc44109.2020.9176845","mag":"3081888830","pmid":"https://pubmed.ncbi.nlm.nih.gov/33019158"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9176845","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176845","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010247617","display_name":"Kevin Shah","orcid":"https://orcid.org/0000-0003-0896-2266"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin A. Shah","raw_affiliation_strings":["Institutes for Medical Research, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutes for Medical Research, Manhasset, NY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033436431","display_name":"Anup N. Sonti","orcid":"https://orcid.org/0000-0002-9532-8214"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anup N. Sonti","raw_affiliation_strings":["Institutes for Medical Research, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutes for Medical Research, Manhasset, NY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028985032","display_name":"Yi-Chen Wu","orcid":"https://orcid.org/0000-0002-1857-9810"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Chen Wu","raw_affiliation_strings":["Institutes for Medical Research, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutes for Medical Research, Manhasset, NY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039844309","display_name":"Keren Powell","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keren Powell","raw_affiliation_strings":["Institutes for Medical Research, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutes for Medical Research, Manhasset, NY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042971715","display_name":"Mohini Doobay","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohini Doobay","raw_affiliation_strings":["Institutes for Medical Research, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutes for Medical Research, Manhasset, NY, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049650232","display_name":"Raj K. Narayan","orcid":"https://orcid.org/0000-0002-5587-8430"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raj K. Narayan","raw_affiliation_strings":["Institutes for Medical Research, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutes for Medical Research, Manhasset, NY, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100409210","display_name":"Chunyan Li","orcid":"https://orcid.org/0000-0001-5169-3976"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunyan Li","raw_affiliation_strings":["Institutes for Medical Research, Manhasset, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutes for Medical Research, Manhasset, NY, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.97101449,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"2020","issue":null,"first_page":"5208","last_page":"5211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reflex","display_name":"Reflex","score":0.7682952880859375},{"id":"https://openalex.org/keywords/trigeminal-nerve","display_name":"Trigeminal nerve","score":0.6860145926475525},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6795762777328491},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.6529791355133057},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6042597889900208},{"id":"https://openalex.org/keywords/infraorbital-nerve","display_name":"Infraorbital nerve","score":0.6008120179176331},{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"Autonomic nervous system","score":0.5024526119232178},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.42295730113983154},{"id":"https://openalex.org/keywords/afferent","display_name":"Afferent","score":0.4199317991733551},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23265710473060608},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.22131171822547913},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12558794021606445},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.10455361008644104}],"concepts":[{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.7682952880859375},{"id":"https://openalex.org/C2777397368","wikidata":"https://www.wikidata.org/wiki/Q189763","display_name":"Trigeminal nerve","level":2,"score":0.6860145926475525},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6795762777328491},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6529791355133057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6042597889900208},{"id":"https://openalex.org/C2780767800","wikidata":"https://www.wikidata.org/wiki/Q1613890","display_name":"Infraorbital nerve","level":2,"score":0.6008120179176331},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.5024526119232178},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.42295730113983154},{"id":"https://openalex.org/C2779263132","wikidata":"https://www.wikidata.org/wiki/Q2215671","display_name":"Afferent","level":2,"score":0.4199317991733551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23265710473060608},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.22131171822547913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12558794021606445},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.10455361008644104}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008442","descriptor_name":"Maxillary Nerve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008442","descriptor_name":"Maxillary Nerve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008442","descriptor_name":"Maxillary Nerve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065508","descriptor_name":"Diving Reflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065508","descriptor_name":"Diving Reflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065508","descriptor_name":"Diving Reflex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc44109.2020.9176845","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176845","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33019158","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33019158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.5600000023841858}],"awards":[{"id":"https://openalex.org/G3310373270","display_name":null,"funder_award_id":"R21 NS114763","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W2008549286","https://openalex.org/W2021155461","https://openalex.org/W2093723753","https://openalex.org/W2102493746","https://openalex.org/W2109194931","https://openalex.org/W2116807025","https://openalex.org/W2149195281","https://openalex.org/W2163041410","https://openalex.org/W2163815564","https://openalex.org/W2169969434","https://openalex.org/W2340067807","https://openalex.org/W2342608000","https://openalex.org/W2612451731","https://openalex.org/W2923396787"],"related_works":["https://openalex.org/W1965075778","https://openalex.org/W2417531167","https://openalex.org/W1998649138","https://openalex.org/W2349773190","https://openalex.org/W2977761393","https://openalex.org/W348488943","https://openalex.org/W2001874790","https://openalex.org/W2028924073","https://openalex.org/W4390285529","https://openalex.org/W2089218434"],"abstract_inverted_index":{"The":[0,36],"\"diving":[1],"reflex\"":[2],"(DR)":[3],"is":[4,173],"a":[5,107,129],"very":[6],"powerful":[7],"autonomic":[8],"reflex":[9],"that":[10,134,167],"facilitates":[11],"survival":[12],"in":[13,87,106,128,150,188],"hypoxic/anoxic":[14],"conditions":[15],"and":[16,33,53,74,103,177],"could":[17],"trigger":[18],"multifaceted":[19],"physiologic":[20],"effects":[21],"for":[22,163],"the":[23,30,49,72,93,115,126,144,155,164,168,171],"treatment":[24],"of":[25,101,117,146,170],"various":[26,186],"diseases":[27],"by":[28,41,175],"modulating":[29],"cardiovascular,":[31],"respiratory,":[32],"nervous":[34,76],"systems.":[35,77],"DR":[37,127,148,172],"can":[38,57],"be":[39,85],"induced":[40],"cold":[42],"water":[43],"or":[44,61],"noxious":[45],"gases":[46],"applied":[47],"to":[48,63,67,84,92,95,124,180],"anterior":[50],"nasal":[51],"mucosa":[52],"paranasal":[54],"regions,":[55],"which":[56,70],"stimulate":[58],"trigeminal":[59],"thermo-":[60],"chemo-receptors":[62],"send":[64],"afferent":[65],"signals":[66],"medullary":[68],"nuclei":[69],"mediate":[71],"sympathetic":[73],"parasympathetic":[75],"Although":[78],"promising,":[79],"these":[80],"approaches":[81],"have":[82],"yet":[83],"adopted":[86],"routine":[88],"clinical":[89,108],"practice":[90],"due":[91],"inability":[94],"precisely":[96],"control":[97],"exposure-response":[98],"relationships,":[99],"lack":[100],"reproducibility,":[102],"difficulty":[104],"implementing":[105],"setting.":[109],"In":[110],"this":[111],"study,":[112],"we":[113],"present":[114],"ability":[116],"electrical":[118],"Trigeminal":[119],"(Infraorbital)":[120],"Nerve":[121],"Stimulation":[122],"(eTINS)":[123],"induce":[125],"dose-controllable":[130],"manner.":[131],"We":[132],"found":[133],"eTINS":[135],"not":[136],"only":[137],"triggered":[138],"specific":[139],"physiological":[140],"changes":[141],"compatible":[142],"with":[143],"pattern":[145],"\"classic\"":[147],"observed":[149],"animals/humans,":[151],"but":[152],"also":[153],"controlled":[154],"induced-DR":[156],"at":[157],"varying":[158],"levels.":[159],"This":[160],"study":[161],"demonstrates,":[162],"first":[165],"time,":[166],"intensity":[169],"controllable":[174],"dose":[176],"opens":[178],"possibility":[179],"investigate":[181],"its":[182],"protective":[183],"mechanism":[184],"against":[185],"pathologies":[187],"well-controlled":[189],"research":[190],"settings.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
