{"id":"https://openalex.org/W3082851050","doi":"https://doi.org/10.1109/embc44109.2020.9176737","title":"Elucidating the relationship between arrhythmia and ischemic heterogeneity: an in silico study","display_name":"Elucidating the relationship between arrhythmia and ischemic heterogeneity: an in silico study","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3082851050","doi":"https://doi.org/10.1109/embc44109.2020.9176737","mag":"3082851050","pmid":"https://pubmed.ncbi.nlm.nih.gov/33018498"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9176737","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176737","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055925254","display_name":"Sanjay Kharche","orcid":"https://orcid.org/0000-0002-2634-4894"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I131944076","display_name":"Lawson Health Research Institute","ror":"https://ror.org/051gsh239","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I131944076"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sanjay R. Kharche","raw_affiliation_strings":["Medical Biophysics, Western University and Lawson Health Research Institute, London Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Medical Biophysics, Western University and Lawson Health Research Institute, London Ontario, Canada","institution_ids":["https://openalex.org/I131944076","https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015041984","display_name":"Kairavi Desai","orcid":"https://orcid.org/0000-0002-7766-4345"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kairavi Desai","raw_affiliation_strings":["Medical Biophysics, Western University"],"affiliations":[{"raw_affiliation_string":"Medical Biophysics, Western University","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023778275","display_name":"Christopher W. McIntyre","orcid":"https://orcid.org/0000-0002-3877-3135"},"institutions":[{"id":"https://openalex.org/I131944076","display_name":"Lawson Health Research Institute","ror":"https://ror.org/051gsh239","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I131944076"]},{"id":"https://openalex.org/I2800925808","display_name":"London Health Sciences Centre","ror":"https://ror.org/037tz0e16","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christopher W. McIntyre","raw_affiliation_strings":["practicing physician (nephrologist) in London Health Sciences Centre, Lawson Health Research Institute, London Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"practicing physician (nephrologist) in London Health Sciences Centre, Lawson Health Research Institute, London Ontario, Canada","institution_ids":["https://openalex.org/I131944076","https://openalex.org/I2800925808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055925254"],"corresponding_institution_ids":["https://openalex.org/I125749732","https://openalex.org/I131944076"],"apc_list":null,"apc_paid":null,"fwci":0.1494,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52945017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"2020","issue":null,"first_page":"2434","last_page":"2437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9891999959945679,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventricle","display_name":"Ventricle","score":0.7287096381187439},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.7024182081222534},{"id":"https://openalex.org/keywords/ischemia","display_name":"Ischemia","score":0.6530614495277405},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.552627444267273},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.5495702624320984},{"id":"https://openalex.org/keywords/fibrillation","display_name":"Fibrillation","score":0.5421565175056458},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5285923480987549},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.38359102606773376},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.18439459800720215}],"concepts":[{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.7287096381187439},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7024182081222534},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6530614495277405},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.552627444267273},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5495702624320984},{"id":"https://openalex.org/C2777356233","wikidata":"https://www.wikidata.org/wiki/Q1001150","display_name":"Fibrillation","level":3,"score":0.5421565175056458},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5285923480987549},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.38359102606773376},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.18439459800720215}],"mesh":[{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054849","descriptor_name":"Cardiac Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054849","descriptor_name":"Cardiac Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054849","descriptor_name":"Cardiac Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc44109.2020.9176737","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176737","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33018498","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33018498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W788330839","https://openalex.org/W1803290497","https://openalex.org/W2019136137","https://openalex.org/W2049124401","https://openalex.org/W2124916848","https://openalex.org/W2125722877","https://openalex.org/W2150990549","https://openalex.org/W2176177265","https://openalex.org/W2230621672","https://openalex.org/W2295445971","https://openalex.org/W2589792216","https://openalex.org/W2801468349"],"related_works":["https://openalex.org/W2402911890","https://openalex.org/W2353214236","https://openalex.org/W2412248164","https://openalex.org/W3025229005","https://openalex.org/W2393441460","https://openalex.org/W4232182196","https://openalex.org/W2022094567","https://openalex.org/W2393721403","https://openalex.org/W3187388830","https://openalex.org/W2418850124"],"abstract_inverted_index":{"Dialysis":[0,215],"causes":[1],"blood":[2],"flow":[3],"defects":[4],"in":[5,13,22,60,130,166],"the":[6,14,23,45,103,111,123,128,131,147,161,167,172],"heart":[7],"that":[8],"may":[9,216],"augment":[10],"electrophysiological":[11,42],"heterogeneity":[12],"form":[15],"of":[16,19,34,44,53,74,77,125,143,151,164,174,198,206],"increased":[17,169,183],"number":[18,33,76,196],"ischemic":[20,35,55,78,85,126,144,176,188,199],"zones":[21,36,86,145,200],"human":[24,46,48],"left":[25],"ventricle.":[26],"We":[27],"computationally":[28],"tested":[29],"whether":[30],"a":[31,40,69,99,194],"larger":[32],"aggravate":[37],"arrhythmia":[38],"using":[39,211],"2D":[41,71,132],"model":[43,51,65,72,133],"ventricle.A":[47],"ventricle":[49],"cardiomyocyte":[50],"capable":[52],"simulating":[54],"action":[56,119,224],"potentials":[57],"was":[58,66,87,95,139],"adapted":[59],"this":[61],"study.":[62],"The":[63,141],"cell":[64],"incorporated":[67],"into":[68],"spatial":[70],"consisting":[73],"known":[75],"zones.":[79,177],"Inter-cellular":[80],"gap":[81],"junction":[82],"coupling":[83],"within":[84],"reduced":[88,117],"to":[89,134,155,190],"simulate":[90],"slow":[91],"conduction.":[92],"Arrhythmia":[93],"severity":[94],"assessed":[96],"by":[97,220],"inducing":[98],"re-entry,":[100],"and":[101,106,116],"quantifying":[102],"ensuing":[104],"breakup":[105],"tissue":[107,222],"pacing":[108,165],"rates.Ischemia":[109],"elevated":[110],"isolated":[112],"cardiomyocyte's":[113],"resting":[114],"potential":[115,120,225],"its":[118],"duration.":[121],"In":[122],"absence":[124],"zones,":[127],"propensity":[129],"induce":[135],"multiple":[136,175],"re-entrant":[137,152],"waves":[138,153],"low.":[140],"inclusion":[142,173],"provided":[146],"substrate":[148],"for":[149],"initiation":[150],"leading":[154],"fibrillation.":[156],"Dominant":[157],"frequency,":[158],"which":[159],"measured":[160],"highest":[162],"rate":[163],"tissue,":[168],"drastically":[170],"with":[171],"Re-entrant":[178],"wave":[179],"tip":[180,186],"maximum":[181],"numbers":[182],"from":[184],"1":[185],"(no":[187],"zone)":[189],"34":[191],"tips":[192],"when":[193],"large":[195],"(20)":[197],"were":[201,209],"included.":[202],"Computational":[203],"limiting":[204],"factors":[205],"our":[207],"platform":[208],"identified":[210],"software":[212],"profiling.Clinical":[213],"significance.":[214],"promote":[217],"deleterious":[218],"arrhythmias":[219],"increasing":[221],"level":[223],"dispersion.":[226]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
