{"id":"https://openalex.org/W3082670693","doi":"https://doi.org/10.1109/embc44109.2020.9176694","title":"Time-Multiplexed Illumination for simultaneous Structural and Functional Voltage Sensitive Dye Recordings with a single Photo Sensor","display_name":"Time-Multiplexed Illumination for simultaneous Structural and Functional Voltage Sensitive Dye Recordings with a single Photo Sensor","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3082670693","doi":"https://doi.org/10.1109/embc44109.2020.9176694","mag":"3082670693","pmid":"https://pubmed.ncbi.nlm.nih.gov/33018372"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9176694","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176694","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034388227","display_name":"Lars Haab","orcid":"https://orcid.org/0000-0003-0941-8545"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars Haab","raw_affiliation_strings":["Systems Neuroscience & Neurotechnology Unit, Faculty of Medicine, Saarland University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Neuroscience & Neurotechnology Unit, Faculty of Medicine, Saarland University","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090197484","display_name":"Philipp Flotho","orcid":"https://orcid.org/0000-0002-8480-0085"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Flotho","raw_affiliation_strings":["Systems Neuroscience & Neurotechnology Unit, Faculty of Medicine, Saarland University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Neuroscience & Neurotechnology Unit, Faculty of Medicine, Saarland University","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037451294","display_name":"David Eckert","orcid":null},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David Eckert","raw_affiliation_strings":["Department of Medical Physics, Saarland University of Applied Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, Saarland University of Applied Sciences","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051690525","display_name":"Karsten Schwerdtfeger","orcid":null},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karsten Schwerdtfeger","raw_affiliation_strings":["Department of Neurosurgery, Saarland University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Saarland University","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001271936","display_name":"Matthias J. M. Huelser","orcid":null},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Huelser","raw_affiliation_strings":["Department of Neurosurgery, Saarland University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Saarland University","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033888574","display_name":"Daniel J. Strau\u00df","orcid":"https://orcid.org/0000-0001-8481-499X"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel J. Strauss","raw_affiliation_strings":["Systems Neuroscience & Neurotechnology Unit, Faculty of Medicine, Saarland University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Neuroscience & Neurotechnology Unit, Faculty of Medicine, Saarland University","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016208719","display_name":"Michael Moeller","orcid":"https://orcid.org/0000-0002-0492-6527"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Moeller","raw_affiliation_strings":["Department of Medical Physics, Saarland University of Applied Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, Saarland University of Applied Sciences","institution_ids":["https://openalex.org/I91712215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I91712215"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1428282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":null,"first_page":"1899","last_page":"1902"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voltage-sensitive-dye","display_name":"Voltage-sensitive dye","score":0.5796762704849243},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.5761207342147827},{"id":"https://openalex.org/keywords/optical-recording","display_name":"Optical recording","score":0.5525769591331482},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.547291100025177},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.5302467346191406},{"id":"https://openalex.org/keywords/temporal-resolution","display_name":"Temporal resolution","score":0.47623541951179504},{"id":"https://openalex.org/keywords/multiplexing","display_name":"Multiplexing","score":0.4394637942314148},{"id":"https://openalex.org/keywords/voltage","display_name":"Voltage","score":0.41648024320602417},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3736811876296997},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.3316792845726013},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.31769391894340515},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.26260703802108765},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.24536266922950745},{"id":"https://openalex.org/keywords/optical-imaging","display_name":"Optical imaging","score":0.1753470003604889}],"concepts":[{"id":"https://openalex.org/C204188946","wikidata":"https://www.wikidata.org/wiki/Q2984404","display_name":"Voltage-sensitive dye","level":3,"score":0.5796762704849243},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.5761207342147827},{"id":"https://openalex.org/C2780524149","wikidata":"https://www.wikidata.org/wiki/Q7098891","display_name":"Optical recording","level":2,"score":0.5525769591331482},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.547291100025177},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.5302467346191406},{"id":"https://openalex.org/C119666444","wikidata":"https://www.wikidata.org/wiki/Q5977280","display_name":"Temporal resolution","level":2,"score":0.47623541951179504},{"id":"https://openalex.org/C19275194","wikidata":"https://www.wikidata.org/wiki/Q222903","display_name":"Multiplexing","level":2,"score":0.4394637942314148},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.41648024320602417},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3736811876296997},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3316792845726013},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.31769391894340515},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.26260703802108765},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.24536266922950745},{"id":"https://openalex.org/C92630104","wikidata":"https://www.wikidata.org/wiki/Q4115103","display_name":"Optical imaging","level":2,"score":0.1753470003604889},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008029","descriptor_name":"Lighting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008029","descriptor_name":"Lighting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008029","descriptor_name":"Lighting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010775","descriptor_name":"Photic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010775","descriptor_name":"Photic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010775","descriptor_name":"Photic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc44109.2020.9176694","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176694","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33018372","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33018372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1826355435","https://openalex.org/W2007436059","https://openalex.org/W2019475363","https://openalex.org/W2020172216","https://openalex.org/W2099211886","https://openalex.org/W2099951301","https://openalex.org/W2126946257","https://openalex.org/W2133720866","https://openalex.org/W2616724104","https://openalex.org/W2945980873"],"related_works":["https://openalex.org/W2471690009","https://openalex.org/W2402275533","https://openalex.org/W4321259452","https://openalex.org/W2379892197","https://openalex.org/W2267522541","https://openalex.org/W2111733068","https://openalex.org/W3147731917","https://openalex.org/W2395659626","https://openalex.org/W164528884","https://openalex.org/W4321266019"],"abstract_inverted_index":{"The":[0,42],"in-vivo":[1],"optical":[2,101,139],"imaging":[3,102],"of":[4,15,34,79,100,113,127,162,185,216,223],"the":[5,9,88,109,125,128,152,182],"cortical":[6,80],"surface":[7],"provides":[8],"ability":[10],"to":[11,56,96,108,119,136,151,157,180,192],"record":[12,137,158],"different":[13,98],"types":[14,99],"biophysiological":[16],"signals,":[17,22],"e.g.,":[18],"structural":[19],"information,":[20],"intrinsic":[21,65,163,186],"like":[23,38],"blood":[24],"oxygenation":[25],"coupled":[26],"reflection":[27],"changes":[28],"as":[29,31,196,198],"well":[30,197],"extrinsic":[32,165,188],"properties":[33],"voltage":[35,154],"sensitive":[36,155],"probes,":[37],"fluorescent":[39],"voltage-sensitive":[40,114],"dyes.":[41],"recorded":[43],"data":[44,68,140,175,218,226],"sets":[45,227],"have":[46,83],"very":[47],"high":[48],"temporal":[49,75],"and":[50,66,76,164,187,202,219],"spatial":[51,77,214],"resolutions":[52],"on":[53],"a":[54,104,147,168,221],"meso-":[55],"macroscopic":[57],"scale,":[58],"which":[59,208],"surpass":[60],"conventional":[61],"multi-electrode":[62],"recordings.":[63],"Both,":[64],"functional":[67,194,217],"sets,":[69],"each":[70],"provide":[71],"unique":[72],"information":[73],"about":[74],"dynamics":[78,189],"functioning,":[81],"yet":[82],"individual":[84],"drawbacks.":[85],"To":[86],"optimize":[87],"informational":[89],"value":[90],"it":[91,116],"would":[92],"thus":[93,134,203],"be":[94,178],"opportune":[95],"combine":[97],"in":[103,209,212,220],"near":[105,173],"simultaneous":[106,174],"recording.Due":[107],"low":[110],"signal-to-noise":[111],"ratio":[112],"dyes":[115],"is":[117,133],"necessary":[118,224],"reduce":[120],"stray":[121],"light":[122],"pollution":[123],"below":[124],"level":[126],"camera's":[129],"dark":[130],"noise.":[131],"It":[132],"impossible":[135],"full-spectrum":[138],"sets.":[141],"We":[142],"address":[143],"this":[144],"problem":[145],"by":[146,167],"time-multiplexed":[148],"illumination,":[149],"bespoke":[150],"utilized":[153],"dye,":[156],"an":[159],"alternating":[160],"series":[161,176],"frames":[166],"high-frequency":[169],"CMOS":[170],"sensor.":[171],"These":[172],"can":[177],"used":[179],"compare":[181],"mutual":[183],"influence":[184],"(with":[190],"regards":[191],"extracorporeal":[193],"imaging)":[195],"for":[199,204],"motion":[200],"compensation":[201],"minimizing":[205],"frame":[206],"averaging,":[207],"turn":[210],"results":[211],"increased":[213],"precision":[215],"reduction":[222],"experimental":[225],"(3R":[228],"principle).":[229]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
