{"id":"https://openalex.org/W3081826695","doi":"https://doi.org/10.1109/embc44109.2020.9176638","title":"Demonstration of Kinematic-Based Closed-loop Deep Brain Stimulation for Mitigating Freezing of Gait in People with Parkinson\u2019s Disease","display_name":"Demonstration of Kinematic-Based Closed-loop Deep Brain Stimulation for Mitigating Freezing of Gait in People with Parkinson\u2019s Disease","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3081826695","doi":"https://doi.org/10.1109/embc44109.2020.9176638","mag":"3081826695","pmid":"https://pubmed.ncbi.nlm.nih.gov/33018784"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9176638","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176638","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8191492","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030644455","display_name":"Johanna O\u2019Day","orcid":"https://orcid.org/0000-0001-7890-5019"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Johanna J. O'Day","raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014674537","display_name":"Yasmine M. Kehnemouyi","orcid":"https://orcid.org/0000-0002-0330-5198"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasmine M. Kehnemouyi","raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025856656","display_name":"Matthew N. Petrucci","orcid":"https://orcid.org/0000-0003-3353-2532"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew N. Petrucci","raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046010504","display_name":"R Anderson","orcid":"https://orcid.org/0000-0001-7624-3138"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross W. Anderson","raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012089090","display_name":"Jeffrey A. Herron","orcid":"https://orcid.org/0000-0002-9813-0094"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Herron","raw_affiliation_strings":["University of Washington, Seattle, WA, USA"],"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089617159","display_name":"Helen Bront\u00eb\u2010Stewart","orcid":"https://orcid.org/0000-0002-1839-4541"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen M. Bronte-Stewart","raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5030644455"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":1.7078,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.87930865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2020","issue":null,"first_page":"3612","last_page":"3616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.8147890567779541},{"id":"https://openalex.org/keywords/kinematics","display_name":"Kinematics","score":0.7850214242935181},{"id":"https://openalex.org/keywords/gait","display_name":"Gait","score":0.7555394172668457},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.7153334617614746},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.676369845867157},{"id":"https://openalex.org/keywords/gait-analysis","display_name":"Gait analysis","score":0.5231786370277405},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4826986789703369},{"id":"https://openalex.org/keywords/inertial-measurement-unit","display_name":"Inertial measurement unit","score":0.4379734992980957},{"id":"https://openalex.org/keywords/accelerometer","display_name":"Accelerometer","score":0.43084716796875},{"id":"https://openalex.org/keywords/wearable-computer","display_name":"Wearable computer","score":0.42538028955459595},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.33087289333343506},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.27714234590530396},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27459219098091125},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.26430365443229675},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0640469491481781}],"concepts":[{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.8147890567779541},{"id":"https://openalex.org/C39920418","wikidata":"https://www.wikidata.org/wiki/Q11476","display_name":"Kinematics","level":2,"score":0.7850214242935181},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.7555394172668457},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.7153334617614746},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.676369845867157},{"id":"https://openalex.org/C173906292","wikidata":"https://www.wikidata.org/wiki/Q1493441","display_name":"Gait analysis","level":3,"score":0.5231786370277405},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4826986789703369},{"id":"https://openalex.org/C79061980","wikidata":"https://www.wikidata.org/wiki/Q941680","display_name":"Inertial measurement unit","level":2,"score":0.4379734992980957},{"id":"https://openalex.org/C89805583","wikidata":"https://www.wikidata.org/wiki/Q192940","display_name":"Accelerometer","level":2,"score":0.43084716796875},{"id":"https://openalex.org/C150594956","wikidata":"https://www.wikidata.org/wiki/Q1334829","display_name":"Wearable computer","level":2,"score":0.42538028955459595},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.33087289333343506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27714234590530396},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27459219098091125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26430365443229675},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0640469491481781},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D020233","descriptor_name":"Gait Disorders, Neurologic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D020233","descriptor_name":"Gait Disorders, Neurologic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D020233","descriptor_name":"Gait Disorders, Neurologic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc44109.2020.9176638","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176638","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33018784","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33018784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8191492","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8191492","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annu Int Conf IEEE Eng Med Biol Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8191492","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8191492","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annu Int Conf IEEE Eng Med Biol Soc","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W2006706761","https://openalex.org/W2015994715","https://openalex.org/W2104499297","https://openalex.org/W2270769397","https://openalex.org/W2536365629","https://openalex.org/W2552340849","https://openalex.org/W2752167926","https://openalex.org/W2814532614","https://openalex.org/W2891923590","https://openalex.org/W2899579807","https://openalex.org/W2906088800","https://openalex.org/W2917762754","https://openalex.org/W3019115200","https://openalex.org/W6763954778"],"related_works":["https://openalex.org/W1973973903","https://openalex.org/W2992410632","https://openalex.org/W2768717251","https://openalex.org/W2025756212","https://openalex.org/W4226182457","https://openalex.org/W2158764002","https://openalex.org/W1557333606","https://openalex.org/W2526786453","https://openalex.org/W3207189946","https://openalex.org/W3082879976"],"abstract_inverted_index":{"Impaired":[0],"gait":[1,16,32,63,74,168],"in":[2,46,89,129,146,170],"Parkinson's":[3,115,171],"disease":[4],"is":[5],"marked":[6],"by":[7,96],"slow,":[8],"arrhythmic":[9],"stepping,":[10],"and":[11,34,65,104,144,162],"often":[12],"includes":[13],"freezing":[14,72],"of":[15,71,73,85,167],"episodes":[17],"where":[18],"alternating":[19],"stepping":[20],"halts":[21],"completely.":[22],"Wearable":[23],"inertial":[24,109],"sensors":[25,110],"offer":[26],"a":[27,47,68,92,112,120,138,147],"way":[28],"to":[29,98,131,159],"detect":[30],"these":[31,87],"changes":[33,126],"novel":[35,57,121],"deep":[36],"brain":[37],"stimulation":[38],"(DBS)":[39],"systems":[40],"can":[41],"respond":[42],"with":[43,91,114],"clinical":[44,148],"therapy":[45],"real-time,":[48],"closed-loop":[49,58,93,153],"fashion.":[50],"In":[51],"this":[52],"paper,":[53],"we":[54],"present":[55,119],"two":[56],"DBS":[59,94,154],"algorithms,":[60],"one":[61,66],"using":[62,67,156],"arrhythmicity":[64],"logistic-regression":[69],"model":[70],"detection":[75],"as":[76],"control":[77,122],"signals.":[78],"Benchtop":[79],"validation":[80],"results":[81,136],"demonstrate":[82],"the":[83,132,151,164],"feasibility":[84],"running":[86],"algorithms":[88,155],"conjunction":[90],"system":[95],"responding":[97],"real-time":[99],"human":[100],"subject":[101],"kinematic":[102,133,157],"data":[103,106],"pre-recorded":[105],"from":[107,111],"leg-worn":[108],"participant":[113],"disease.":[116,172],"We":[117],"also":[118],"policy":[123],"algorithm":[124],"that":[125],"neurostimulator":[127],"frequency":[128],"response":[130],"inputs.":[134],"These":[135],"provide":[137],"foundation":[139],"for":[140,150],"further":[141],"development,":[142],"iteration,":[143],"testing":[145],"trial":[149],"first":[152],"signals":[158],"therapeutically":[160],"improve":[161],"understand":[163],"pathophysiological":[165],"mechanisms":[166],"impairment":[169]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-03-05T09:29:38.588285","created_date":"2020-09-08T00:00:00"}
