{"id":"https://openalex.org/W3081686270","doi":"https://doi.org/10.1109/embc44109.2020.9176556","title":"Identification of differentially expressed subpathways via a bilevel consensus scoring of network topology and gene expression","display_name":"Identification of differentially expressed subpathways via a bilevel consensus scoring of network topology and gene expression","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3081686270","doi":"https://doi.org/10.1109/embc44109.2020.9176556","mag":"3081686270","pmid":"https://pubmed.ncbi.nlm.nih.gov/33019184"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9176556","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176556","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001694584","display_name":"Panos Balomenos","orcid":"https://orcid.org/0000-0002-1074-5933"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panos Balomenos","raw_affiliation_strings":["Department of Computer Engineering and Informatics and the Department of Medicine, University of Patras, Patras, GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering and Informatics and the Department of Medicine, University of Patras, Patras, GR","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077677147","display_name":"Andrei Dragomir","orcid":"https://orcid.org/0000-0003-2815-6958"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Andrei Dragomir","raw_affiliation_strings":["Department of Medicine, University of Patras, Patras, GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Patras, Patras, GR","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104359657","display_name":"Athanasios K. Tsakalidis","orcid":null},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Athanasios K. Tsakalidis","raw_affiliation_strings":["Department of Computer Engineering and Informatics, University of Patras, Patras, GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering and Informatics, University of Patras, Patras, GR","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080347335","display_name":"Anastasios Bezerianos","orcid":"https://orcid.org/0000-0002-8199-6000"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasios Bezerianos","raw_affiliation_strings":["Department of Medicine, University of Patras, Patras, GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Patras, Patras, GR","institution_ids":["https://openalex.org/I174878644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I174878644"],"apc_list":null,"apc_paid":null,"fwci":0.7346,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70728793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"41","issue":null,"first_page":"5316","last_page":"5319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6710503101348877},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6070331931114197},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.57587730884552},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.49220481514930725},{"id":"https://openalex.org/keywords/haematopoiesis","display_name":"Haematopoiesis","score":0.4481991231441498},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.4386102557182312},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.42808935046195984},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3921690583229065},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38810741901397705},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.308668315410614},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.21400678157806396},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1855754554271698},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.16818293929100037},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15733256936073303},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09202572703361511}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6710503101348877},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6070331931114197},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.57587730884552},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.49220481514930725},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4481991231441498},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.4386102557182312},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42808935046195984},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3921690583229065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38810741901397705},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.308668315410614},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21400678157806396},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1855754554271698},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.16818293929100037},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15733256936073303},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09202572703361511},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032921","descriptor_name":"Consensus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032921","descriptor_name":"Consensus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032921","descriptor_name":"Consensus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc44109.2020.9176556","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176556","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33019184","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33019184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1560028517","https://openalex.org/W1971937094","https://openalex.org/W1990678336","https://openalex.org/W1999086631","https://openalex.org/W2007572995","https://openalex.org/W2015291385","https://openalex.org/W2026457140","https://openalex.org/W2049380243","https://openalex.org/W2087194317","https://openalex.org/W2105734437","https://openalex.org/W2106462080","https://openalex.org/W2138069352","https://openalex.org/W2138621811","https://openalex.org/W2140000393","https://openalex.org/W2175798269","https://openalex.org/W2226630938","https://openalex.org/W2302110566","https://openalex.org/W2314047536","https://openalex.org/W2332744688","https://openalex.org/W2342313938","https://openalex.org/W2398534503","https://openalex.org/W2407975629","https://openalex.org/W2410743230","https://openalex.org/W2512003690","https://openalex.org/W2592615787","https://openalex.org/W2594707750","https://openalex.org/W2620975679","https://openalex.org/W2796961799","https://openalex.org/W2890947828","https://openalex.org/W2901822048","https://openalex.org/W2910212832","https://openalex.org/W2945138188","https://openalex.org/W2999180739","https://openalex.org/W3004540582","https://openalex.org/W3023126635","https://openalex.org/W4235592546","https://openalex.org/W4237772191"],"related_works":["https://openalex.org/W2079838338","https://openalex.org/W2086397253","https://openalex.org/W2076802652","https://openalex.org/W1991432514","https://openalex.org/W2784395700","https://openalex.org/W2018552733","https://openalex.org/W2015726247","https://openalex.org/W2592615787","https://openalex.org/W2045505363","https://openalex.org/W3012964845"],"abstract_inverted_index":{"Identifying":[0],"differentially":[1,40],"expressed":[2,41],"subpathways":[3,42,57],"connected":[4,45],"to":[5,38,61],"the":[6,72],"emergence":[7],"of":[8,71],"a":[9,25,33,65,77],"disease":[10],"that":[11,43],"can":[12],"be":[13],"considered":[14],"as":[15],"candidates":[16],"for":[17],"pharmacological":[18],"intervention,":[19],"with":[20,46,83],"minimal":[21],"off-target":[22],"effects,":[23],"is":[24,74],"daunting":[26],"task.":[27],"In":[28],"this":[29],"direction,":[30],"we":[31],"present":[32],"bilevel":[34],"subpathway":[35],"analysis":[36],"method":[37,73],"identify":[39],"are":[44],"an":[47],"experimental":[48],"condition,":[49],"while":[50],"taking":[51],"into":[52],"account":[53],"potential":[54],"crosstalks":[55],"between":[56],"which":[58],"arise":[59],"due":[60],"their":[62],"connectivity":[63],"in":[64],"combined":[66],"multi-pathway":[67],"network.":[68],"The":[69],"efficacy":[70],"demonstrated":[75],"on":[76],"hematopoietic":[78],"stem":[79],"cell":[80],"aging":[81],"dataset,":[82],"findings":[84],"corroborated":[85],"using":[86],"recent":[87],"literature.":[88]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}