{"id":"https://openalex.org/W3082551304","doi":"https://doi.org/10.1109/embc44109.2020.9176518","title":"A Method for Deciphering Major Drivers of Bacterial Iron Stress Response in the Presence of Oxidative Stressors","display_name":"A Method for Deciphering Major Drivers of Bacterial Iron Stress Response in the Presence of Oxidative Stressors","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3082551304","doi":"https://doi.org/10.1109/embc44109.2020.9176518","mag":"3082551304","pmid":"https://pubmed.ncbi.nlm.nih.gov/33018459"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9176518","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176518","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054548307","display_name":"Daniel C. Ajuzie","orcid":null},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel C. Ajuzie","raw_affiliation_strings":["Department of Biomedical, University of Houston"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical, University of Houston","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014174072","display_name":"Seyed A. Arshad","orcid":"https://orcid.org/0000-0001-6350-3148"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seyed A. Arshad","raw_affiliation_strings":["implemented initial model and generated experimental data"],"affiliations":[{"raw_affiliation_string":"implemented initial model and generated experimental data","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019367809","display_name":"Komal S. Rasaputra","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Komal S. Rasaputra","raw_affiliation_strings":["developed experimental model and generated data"],"affiliations":[{"raw_affiliation_string":"developed experimental model and generated data","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112306313","display_name":"Elebeoba E. May","orcid":null},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elebeoba E. May","raw_affiliation_strings":["Department of Biomedical Engineering, University of Houston, Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I44461941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054548307"],"corresponding_institution_ids":["https://openalex.org/I44461941"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.10362951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"2020","issue":null,"first_page":"2266","last_page":"2269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11231","display_name":"Microbial Fuel Cells and Bioremediation","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2305","display_name":"Environmental Engineering"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9611999988555908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"Oxidative stress","score":0.7052075862884521},{"id":"https://openalex.org/keywords/stressor","display_name":"Stressor","score":0.5953930616378784},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"Hydrogen peroxide","score":0.5542395710945129},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.535322368144989},{"id":"https://openalex.org/keywords/stress","display_name":"Stress (linguistics)","score":0.49674707651138306},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35494470596313477},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.34270602464675903},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3215278387069702},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2360054850578308},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19617575407028198},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1402912437915802},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.12115466594696045}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7052075862884521},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.5953930616378784},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.5542395710945129},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.535322368144989},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.49674707651138306},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35494470596313477},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34270602464675903},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3215278387069702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2360054850578308},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19617575407028198},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1402912437915802},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.12115466594696045},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc44109.2020.9176518","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176518","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33018459","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33018459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1964508389","https://openalex.org/W1982478920","https://openalex.org/W2003550923","https://openalex.org/W2011320012","https://openalex.org/W2014723793","https://openalex.org/W2044697909","https://openalex.org/W2047470590","https://openalex.org/W2075632982","https://openalex.org/W2102837720","https://openalex.org/W2108192886","https://openalex.org/W2140937954","https://openalex.org/W2149076623","https://openalex.org/W2149863399","https://openalex.org/W2152803686","https://openalex.org/W2484315394","https://openalex.org/W2527398833","https://openalex.org/W2899903294","https://openalex.org/W2923938753","https://openalex.org/W2954205175"],"related_works":["https://openalex.org/W2360987025","https://openalex.org/W2387178301","https://openalex.org/W3144733943","https://openalex.org/W2785993273","https://openalex.org/W2382269147","https://openalex.org/W3184323118","https://openalex.org/W2016696944","https://openalex.org/W2799462113","https://openalex.org/W36834100","https://openalex.org/W2805205084"],"abstract_inverted_index":{"This":[0],"paper":[1],"describes":[2],"a":[3,21,59],"method":[4],"for":[5,68],"deciphering":[6],"major":[7,69],"drivers":[8,71],"of":[9,24,46,72],"bacterial":[10,53,74],"stress":[11,31,51],"response":[12,32,75],"using":[13,64],"an":[14],"empirically":[15],"informed":[16],"computational":[17],"approach.":[18],"We":[19,57],"develop":[20],"working":[22],"model":[23,38],"iron":[25,47,77],"flux":[26],"regulation":[27],"and":[28,48,55],"concomitant":[29],"oxidative":[30],"in":[33],"Escherichia":[34],"coli.":[35],"The":[36],"integrated":[37],"is":[39],"used":[40],"to":[41,76],"investigate":[42],"the":[43,73],"temporal":[44],"effects":[45],"hydrogen":[49],"peroxide":[50],"on":[52],"growth":[54],"metabolism.":[56],"employ":[58],"sensitivity":[60],"analysis":[61],"platform":[62],"and,":[63],"various":[65],"measures,":[66],"probe":[67],"mechanistic":[70],"stress.":[78]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-02-12T06:13:03.167441","created_date":"2025-10-10T00:00:00"}