{"id":"https://openalex.org/W2994263134","doi":"https://doi.org/10.1109/embc44109.2020.9176452","title":"Individualized closed-loop anesthesia through patient model partitioning","display_name":"Individualized closed-loop anesthesia through patient model partitioning","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W2994263134","doi":"https://doi.org/10.1109/embc44109.2020.9176452","mag":"2994263134","pmid":"https://pubmed.ncbi.nlm.nih.gov/33018003"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9176452","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176452","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lup.lub.lu.se/record/210bfdf2-1359-4eed-a61e-75f1b360e1cf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033021355","display_name":"Ylva Wahlquist","orcid":"https://orcid.org/0000-0001-7265-5012"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Ylva Wahlquist","raw_affiliation_strings":["Department of Automatic Control, Lund University, Lund, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Automatic Control, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009577016","display_name":"Klaske van Heusden","orcid":"https://orcid.org/0000-0003-2763-5279"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Klaske van Heusden","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055045540","display_name":"Guy A. Dumont","orcid":"https://orcid.org/0000-0003-2048-4391"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Guy A. Dumont","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087697079","display_name":"Kristian Soltesz","orcid":"https://orcid.org/0000-0001-6378-7646"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kristian Soltesz","raw_affiliation_strings":["Department of Automatic Control, Lund University, Lund, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Automatic Control, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033021355"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":null,"apc_paid":null,"fwci":1.7512,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.83423773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"2020","issue":null,"first_page":"361","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.9763000011444092,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dosing","display_name":"Dosing","score":0.6054438948631287},{"id":"https://openalex.org/keywords/safer","display_name":"SAFER","score":0.5447985529899597},{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.538970410823822},{"id":"https://openalex.org/keywords/closed-loop","display_name":"Closed loop","score":0.5281211137771606},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5192039608955383},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.5103966593742371},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.485999196767807},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.46388134360313416},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"Pharmacodynamics","score":0.45174193382263184},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.4197115898132324},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3147599697113037},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.29565533995628357},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.25524628162384033},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.23014798760414124},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.22857040166854858},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.16020417213439941},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1538296341896057}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6054438948631287},{"id":"https://openalex.org/C2776654903","wikidata":"https://www.wikidata.org/wiki/Q2601463","display_name":"SAFER","level":2,"score":0.5447985529899597},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.538970410823822},{"id":"https://openalex.org/C3019251811","wikidata":"https://www.wikidata.org/wiki/Q5135346","display_name":"Closed loop","level":2,"score":0.5281211137771606},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5192039608955383},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.5103966593742371},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.485999196767807},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.46388134360313416},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.45174193382263184},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.4197115898132324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3147599697113037},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29565533995628357},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.25524628162384033},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.23014798760414124},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.22857040166854858},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.16020417213439941},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1538296341896057},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1109/embc44109.2020.9176452","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176452","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33018003","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33018003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:lup.lub.lu.se:210bfdf2-1359-4eed-a61e-75f1b360e1cf","is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/210bfdf2-1359-4eed-a61e-75f1b360e1cf","pdf_url":"https://lup.lub.lu.se/record/210bfdf2-1359-4eed-a61e-75f1b360e1cf","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2694-0604","raw_type":"text"},{"id":"pmh:oai:lup-student-papers.lub.lu.se:8975222","is_oa":false,"landing_page_url":"http://lup.lub.lu.se/student-papers/record/8975222","pdf_url":null,"source":{"id":"https://openalex.org/S4306402420","display_name":"Lund University Publications Student Papers (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"H3"}],"best_oa_location":{"id":"pmh:oai:lup.lub.lu.se:210bfdf2-1359-4eed-a61e-75f1b360e1cf","is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/210bfdf2-1359-4eed-a61e-75f1b360e1cf","pdf_url":"https://lup.lub.lu.se/record/210bfdf2-1359-4eed-a61e-75f1b360e1cf","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2694-0604","raw_type":"text"},"sustainable_development_goals":[{"score":0.47999998927116394,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2994263134.pdf"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W597526370","https://openalex.org/W1493454437","https://openalex.org/W1995868518","https://openalex.org/W2037348596","https://openalex.org/W2052952057","https://openalex.org/W2059926983","https://openalex.org/W2063126481","https://openalex.org/W2121947440","https://openalex.org/W2124337383","https://openalex.org/W2137164841","https://openalex.org/W2162067857","https://openalex.org/W2165874743","https://openalex.org/W2900652968","https://openalex.org/W2913471540","https://openalex.org/W2999729612","https://openalex.org/W4213009331","https://openalex.org/W6684578312","https://openalex.org/W6756058295"],"related_works":["https://openalex.org/W2953205341","https://openalex.org/W235065745","https://openalex.org/W2029935773","https://openalex.org/W2787754950","https://openalex.org/W1572215850","https://openalex.org/W1985775355","https://openalex.org/W2352115286","https://openalex.org/W2084793300","https://openalex.org/W2476350415","https://openalex.org/W599377045"],"abstract_inverted_index":{"Closed-loop":[0],"controlled":[1],"drug":[2,15],"dosing":[3],"has":[4,140],"the":[5,22,91,103,144],"potential":[6,141],"of":[7,24,44,49,90,118,160],"revolutionizing":[8],"clinical":[9,137],"anesthesia.":[10],"However,":[11],"inter-patient":[12,60],"variability":[13],"in":[14,111,136,153],"sensitivity":[16],"poses":[17],"a":[18,28,55,69,112,116],"central":[19],"challenge":[20],"to":[21,41,58,134,142,151],"synthesis":[23,36],"safe":[25],"controllers.":[26],"Identifying":[27],"full":[29],"individual":[30],"pharmacokinetic-pharmacodynamic":[31],"(PKPD)":[32],"model":[33,72],"for":[34,82],"this":[35],"is":[37,63,109,132],"clinically":[38,120],"infeasible":[39],"due":[40],"limited":[42],"excitation":[43],"PKPD":[45],"dynamics":[46],"and":[47,127,139,150,162],"presence":[48],"unmodeled":[50],"disturbances.":[51],"This":[52],"work":[53],"presents":[54],"novel":[56],"method":[57,108,131],"mitigate":[59],"variability.":[61],"It":[62],"based":[64,94],"on:":[65],"1)":[66],"partitioning":[67],"an":[68,78],"priori":[70],"known":[71],"set":[73,117],"into":[74,88],"subsets;":[75],"2)":[76],"synthesizing":[77],"optimal":[79],"robust":[80],"controller":[81],"each":[83],"subset;":[84],"3)":[85],"classifying":[86],"patients":[87],"one":[89],"subsets":[92],"online":[93],"on":[95],"demographic":[96],"or":[97],"induction":[98],"phase":[99],"data;":[100],"4)":[101],"applying":[102],"associated":[104],"closed-loop":[105,155],"controller.":[106],"The":[107],"investigated":[110],"simulation":[113],"study,":[114],"utilizing":[115],"47":[119],"obtained":[121],"patient":[122],"models.":[123],"Results":[124],"are":[125],"presented":[126],"discussed.Clinical":[128],"relevance-The":[129],"proposed":[130],"easy":[133],"implement":[135],"practice,":[138],"reduce":[143],"impact":[145],"from":[146],"surgical":[147],"stimulation":[148],"disturbances,":[149],"result":[152],"safer":[154],"anesthesia":[156],"with":[157],"less":[158],"risk":[159],"under-":[161],"over":[163],"dosing.":[164]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
