{"id":"https://openalex.org/W3082646539","doi":"https://doi.org/10.1109/embc44109.2020.9176371","title":"Automatic Shape Optimization of Patient-Specific Tissue Engineered Vascular Grafts for Aortic Coarctation","display_name":"Automatic Shape Optimization of Patient-Specific Tissue Engineered Vascular Grafts for Aortic Coarctation","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3082646539","doi":"https://doi.org/10.1109/embc44109.2020.9176371","mag":"3082646539","pmid":"https://pubmed.ncbi.nlm.nih.gov/33018472"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9176371","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176371","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054750358","display_name":"Xiaolong Liu","orcid":"https://orcid.org/0000-0001-5335-3473"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaolong Liu","raw_affiliation_strings":["Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046661486","display_name":"Seda Aslan","orcid":"https://orcid.org/0000-0002-5682-4848"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seda Aslan","raw_affiliation_strings":["Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005206634","display_name":"Rachel Hess","orcid":null},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Hess","raw_affiliation_strings":["Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076051189","display_name":"Paige Mass","orcid":"https://orcid.org/0000-0002-5778-9300"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paige Mass","raw_affiliation_strings":["Children's National Hospital, Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's National Hospital, Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington DC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075009634","display_name":"Laura Olivieri","orcid":"https://orcid.org/0000-0002-3783-0783"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Olivieri","raw_affiliation_strings":["Children's National Hospital, Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's National Hospital, Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington DC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042337657","display_name":"Yue\u2010Hin Loke","orcid":"https://orcid.org/0000-0003-1003-1903"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue-Hin Loke","raw_affiliation_strings":["Children's National Hospital, Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's National Hospital, Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington DC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022095208","display_name":"Narutoshi Hibino","orcid":"https://orcid.org/0000-0003-4551-9079"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Narutoshi Hibino","raw_affiliation_strings":["Department of Cardiac Surgery, The University of Chicago Medicine, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, The University of Chicago Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036788329","display_name":"Mark Fuge","orcid":"https://orcid.org/0000-0003-3819-8895"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Fuge","raw_affiliation_strings":["Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008331040","display_name":"Axel Krieger","orcid":"https://orcid.org/0000-0001-8169-075X"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Axel Krieger","raw_affiliation_strings":["Department of Mechanical Engineering, University of Maryland, College Park, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9524,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.71224347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"2020","issue":null,"first_page":"2319","last_page":"2323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9760000109672546,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9760000109672546,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9254999756813049,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.9222000241279602,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surrogate-model","display_name":"Surrogate model","score":0.690967321395874},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5273338556289673},{"id":"https://openalex.org/keywords/conjugate-gradient-method","display_name":"Conjugate gradient method","score":0.4688611626625061},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.44031038880348206},{"id":"https://openalex.org/keywords/reduction","display_name":"Reduction (mathematics)","score":0.42342495918273926},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.4161718189716339},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3504500687122345},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3377474844455719},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19950973987579346},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.14521834254264832},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09874728322029114},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.08415862917900085},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.08138054609298706}],"concepts":[{"id":"https://openalex.org/C131675550","wikidata":"https://www.wikidata.org/wiki/Q7646884","display_name":"Surrogate model","level":2,"score":0.690967321395874},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5273338556289673},{"id":"https://openalex.org/C81184566","wikidata":"https://www.wikidata.org/wiki/Q1191895","display_name":"Conjugate gradient method","level":2,"score":0.4688611626625061},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.44031038880348206},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.42342495918273926},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4161718189716339},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3504500687122345},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3377474844455719},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19950973987579346},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.14521834254264832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09874728322029114},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08415862917900085},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.08138054609298706},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001017","descriptor_name":"Aortic Coarctation","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001017","descriptor_name":"Aortic Coarctation","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001017","descriptor_name":"Aortic Coarctation","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001807","descriptor_name":"Blood Vessel Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001807","descriptor_name":"Blood Vessel Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001807","descriptor_name":"Blood Vessel Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014656","descriptor_name":"Vascular Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014656","descriptor_name":"Vascular Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014656","descriptor_name":"Vascular Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc44109.2020.9176371","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176371","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33018472","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33018472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.9100000262260437}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W148894622","https://openalex.org/W967506546","https://openalex.org/W1991323175","https://openalex.org/W2012517517","https://openalex.org/W2023166500","https://openalex.org/W2023541363","https://openalex.org/W2024168274","https://openalex.org/W2059471356","https://openalex.org/W2098449997","https://openalex.org/W2112998683","https://openalex.org/W2126125036","https://openalex.org/W2252738778","https://openalex.org/W2343127218","https://openalex.org/W2557199690","https://openalex.org/W2605203786","https://openalex.org/W2773595117","https://openalex.org/W3000457424"],"related_works":["https://openalex.org/W2034060070","https://openalex.org/W4229957265","https://openalex.org/W2544771389","https://openalex.org/W2386899346","https://openalex.org/W3082608044","https://openalex.org/W2375597358","https://openalex.org/W2912622974","https://openalex.org/W2621058457","https://openalex.org/W1984204070","https://openalex.org/W2129625121"],"abstract_inverted_index":{"This":[0],"paper":[1],"proposes":[2],"a":[3,19,37,76,121],"computational":[4,28,46],"framework":[5,29],"for":[6,23,50,79],"automatically":[7],"optimizing":[8,135],"the":[9,54,99,103,107,110,114,131,136],"shapes":[10],"of":[11,31,56,82],"patient-specific":[12],"tissue":[13],"engineered":[14],"vascular":[15],"grafts.":[16],"We":[17],"demonstrate":[18],"proof-of-concept":[20],"design":[21,57,88,111],"optimization":[22,97],"aortic":[24,137],"coarctation":[25,133],"repair.":[26],"The":[27,85],"consists":[30],"three":[32],"main":[33],"components":[34],"including":[35],"1)":[36],"free-form":[38],"deformation":[39],"technique":[40],"exploring":[41],"graft":[42],"geometries,":[43],"2)":[44],"high-fidelity":[45,83],"fluid":[47],"dynamics":[48],"simulations":[49],"collecting":[51],"data":[52],"on":[53,59,98],"effects":[55],"parameters":[58,89,112],"objective":[60,115],"function":[61,116],"values":[62],"like":[63],"energy":[64,127],"loss,":[65],"and":[66,113],"3)":[67],"employing":[68],"machine":[69],"learning":[70],"methods":[71],"(Gaussian":[72],"Processes)":[73],"to":[74,130],"develop":[75],"surrogate":[77,100],"model":[78],"predicting":[80],"results":[81,119],"simulations.":[84],"globally":[86],"optimal":[87],"are":[90],"then":[91],"computed":[92],"by":[93,134],"multistart":[94],"conjugate":[95],"gradient":[96],"model.":[101],"In":[102],"experiment,":[104],"we":[105],"investigate":[106],"correlation":[108],"among":[109],"values.":[117],"Our":[118],"achieve":[120],"30%":[122],"reduction":[123],"in":[124],"blood":[125],"flow":[126],"loss":[128],"compared":[129],"original":[132],"geometry.":[138]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
