{"id":"https://openalex.org/W3082147915","doi":"https://doi.org/10.1109/embc44109.2020.9176192","title":"Diffusion Kurtosis Imaging Reveals Optic Tract Damage That Correlates with Clinical Severity in Glaucoma","display_name":"Diffusion Kurtosis Imaging Reveals Optic Tract Damage That Correlates with Clinical Severity in Glaucoma","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3082147915","doi":"https://doi.org/10.1109/embc44109.2020.9176192","mag":"3082147915","pmid":"https://pubmed.ncbi.nlm.nih.gov/33018335"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9176192","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176192","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8163524","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100747947","display_name":"Zhe Sun","orcid":"https://orcid.org/0000-0002-6043-8675"},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhe Sun","raw_affiliation_strings":["Department of Ophthalmology, NYU Langone Health, New York University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, NYU Langone Health, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053715191","display_name":"Carlos Parra","orcid":"https://orcid.org/0000-0002-9695-3775"},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Parra","raw_affiliation_strings":["Department of Ophthalmology, NYU Langone Health, New York University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, NYU Langone Health, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042444208","display_name":"Ji Won Bang","orcid":"https://orcid.org/0000-0002-9739-3474"},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ji Won Bang","raw_affiliation_strings":["Department of Ophthalmology, NYU Langone Health, New York University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, NYU Langone Health, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064709895","display_name":"Els Fieremans","orcid":"https://orcid.org/0000-0002-1384-8591"},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Els Fieremans","raw_affiliation_strings":["Department of Radiology, NYU Langone Health, New York University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, NYU Langone Health, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090027463","display_name":"Gadi Wollstein","orcid":"https://orcid.org/0000-0001-7036-2726"},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gadi Wollstein","raw_affiliation_strings":["Department of Ophthalmology, NYU Langone Health, New York University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, NYU Langone Health, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030747987","display_name":"Joel S. Schuman","orcid":"https://orcid.org/0000-0002-8885-3766"},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel S. Schuman","raw_affiliation_strings":["Department of Ophthalmology, NYU Langone Health, New York University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, NYU Langone Health, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047889114","display_name":"Kevin C. Chan","orcid":"https://orcid.org/0000-0003-4012-7084"},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin C. Chan","raw_affiliation_strings":["Departments of Ophthalmology and Radiology, NYU Langone Health, New York University, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Ophthalmology and Radiology, NYU Langone Health, New York University, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210086933"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2020","issue":null,"first_page":"1746","last_page":"1749"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11929","display_name":"Cerebral Venous Sinus Thrombosis","score":0.9692999720573425,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaucoma","display_name":"Glaucoma","score":0.7825472354888916},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.7206707000732422},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.7178918719291687},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"Fractional anisotropy","score":0.6058181524276733},{"id":"https://openalex.org/keywords/optic-tract","display_name":"Optic tract","score":0.602523684501648},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.5828484296798706},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5701651573181152},{"id":"https://openalex.org/keywords/optic-nerve","display_name":"Optic nerve","score":0.5505104064941406},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5403227806091309},{"id":"https://openalex.org/keywords/visual-field","display_name":"Visual field","score":0.5341894030570984},{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"Optical coherence tomography","score":0.46307551860809326},{"id":"https://openalex.org/keywords/kurtosis","display_name":"Kurtosis","score":0.4204511046409607},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3671872019767761},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.2507514953613281}],"concepts":[{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.7825472354888916},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.7206707000732422},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.7178918719291687},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.6058181524276733},{"id":"https://openalex.org/C36388723","wikidata":"https://www.wikidata.org/wiki/Q1079316","display_name":"Optic tract","level":3,"score":0.602523684501648},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5828484296798706},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5701651573181152},{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.5505104064941406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5403227806091309},{"id":"https://openalex.org/C2776058522","wikidata":"https://www.wikidata.org/wiki/Q2364768","display_name":"Visual field","level":2,"score":0.5341894030570984},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.46307551860809326},{"id":"https://openalex.org/C166963901","wikidata":"https://www.wikidata.org/wiki/Q287251","display_name":"Kurtosis","level":2,"score":0.4204511046409607},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3671872019767761},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2507514953613281},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065866","descriptor_name":"Optic Tract","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065866","descriptor_name":"Optic Tract","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065866","descriptor_name":"Optic Tract","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc44109.2020.9176192","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176192","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33018335","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33018335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8163524","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8163524","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annu Int Conf IEEE Eng Med Biol Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8163524","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8163524","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annu Int Conf IEEE Eng Med Biol Soc","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3986837662","display_name":null,"funder_award_id":"R01 NS088040","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4839944860","display_name":null,"funder_award_id":"R01 EY028125","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7759058944","display_name":null,"funder_award_id":"P41 EB017183","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1797584621","https://openalex.org/W1992473488","https://openalex.org/W1994831981","https://openalex.org/W2000794313","https://openalex.org/W2034742711","https://openalex.org/W2104280893","https://openalex.org/W2133243800","https://openalex.org/W2139158372","https://openalex.org/W2142018683","https://openalex.org/W2159883194","https://openalex.org/W2340872164","https://openalex.org/W2510354744","https://openalex.org/W2792187032","https://openalex.org/W2887206520","https://openalex.org/W2908976211","https://openalex.org/W2977883299"],"related_works":["https://openalex.org/W2975118136","https://openalex.org/W2021404550","https://openalex.org/W2094520489","https://openalex.org/W3198083219","https://openalex.org/W2416740390","https://openalex.org/W1980353880","https://openalex.org/W2064873174","https://openalex.org/W1970059351","https://openalex.org/W2341740053","https://openalex.org/W2007896059"],"abstract_inverted_index":{"Glaucoma":[0],"is":[1,10],"a":[2],"neurodegenerative":[3],"disease":[4],"of":[5,14,30,42,66],"the":[6,11,28,39,43,63,77,95,106,164],"visual":[7,44,144],"system":[8],"and":[9,58,76,91,102,127,143,151,155],"leading":[12],"cause":[13],"irreversible":[15],"blindness":[16],"worldwide.":[17],"To":[18],"date,":[19],"its":[20],"pathophysiological":[21],"mechanisms":[22],"remain":[23],"unclear.":[24],"This":[25],"study":[26],"evaluated":[27],"feasibility":[29],"advanced":[31],"diffusion":[32,50,72],"magnetic":[33],"resonance":[34],"imaging":[35,52,74,157],"techniques":[36],"for":[37,159],"examining":[38],"microstructural":[40],"environment":[41],"pathway":[45],"in":[46,62,94,105,109,122,163],"glaucoma.":[47,123],"While":[48],"conventional":[49],"tensor":[51],"(DTI)":[53],"showed":[54],"lower":[55,86,98,103],"fractional":[56],"anisotropy":[57],"higher":[59,89],"directional":[60],"diffusivities":[61,93],"optic":[64],"tracts":[65],"glaucoma":[67,110],"patients":[68],"than":[69],"healthy":[70],"controls,":[71],"kurtosis":[73],"(DKI)":[75],"extended":[78],"white":[79,165],"matter":[80,166],"tract":[81,167],"integrity":[82,121],"(WMTI)":[83],"model":[84],"indicated":[85],"radial":[87,92],"kurtosis,":[88],"axial":[90],"extra-axonal":[96],"space,":[97],"axonal":[99,120],"water":[100],"fraction,":[101],"tortuosity":[104],"same":[107],"regions":[108],"patients.":[111],"These":[112],"findings":[113],"suggest":[114],"glial":[115],"involvements":[116],"apart":[117],"from":[118],"compromised":[119],"In":[124],"addition,":[125],"DKI":[126,150],"WMTI":[128,152],"but":[129],"not":[130],"DTI":[131],"parameters":[132],"significantly":[133],"correlated":[134],"with":[135],"clinical":[136,169],"ophthalmic":[137],"measures":[138],"via":[139],"optical":[140],"coherence":[141],"tomography":[142],"field":[145],"perimetry":[146],"testing.":[147],"Taken":[148],"together,":[149],"provided":[153],"sensitive":[154],"comprehensive":[156],"biomarkers":[158],"quantifying":[160],"glaucomatous":[161],"damage":[162],"across":[168],"severity":[170],"complementary":[171],"to":[172],"DTI.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
