{"id":"https://openalex.org/W3082374971","doi":"https://doi.org/10.1109/embc44109.2020.9176014","title":"Self-Regulated and Co-ordinated Smart Tumor Homing for Complex Vascular Networks","display_name":"Self-Regulated and Co-ordinated Smart Tumor Homing for Complex Vascular Networks","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3082374971","doi":"https://doi.org/10.1109/embc44109.2020.9176014","mag":"3082374971","pmid":"https://pubmed.ncbi.nlm.nih.gov/33018007"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9176014","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176014","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020480150","display_name":"Muhammad Ali","orcid":"https://orcid.org/0000-0003-4562-504X"},"institutions":[{"id":"https://openalex.org/I52179390","display_name":"University of Waikato","ror":"https://ror.org/013fsnh78","country_code":"NZ","type":"education","lineage":["https://openalex.org/I52179390"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Muhammad Ali","raw_affiliation_strings":["School of Engineering, University of Waikato, Hamilton, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering, University of Waikato, Hamilton, New Zealand","institution_ids":["https://openalex.org/I52179390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018585488","display_name":"Neda Sharifi","orcid":"https://orcid.org/0000-0002-3263-5903"},"institutions":[{"id":"https://openalex.org/I52179390","display_name":"University of Waikato","ror":"https://ror.org/013fsnh78","country_code":"NZ","type":"education","lineage":["https://openalex.org/I52179390"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Neda Sharifi","raw_affiliation_strings":["School of Engineering, University of Waikato, Hamilton, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering, University of Waikato, Hamilton, New Zealand","institution_ids":["https://openalex.org/I52179390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078845309","display_name":"Nicholas McGrath","orcid":null},"institutions":[{"id":"https://openalex.org/I52179390","display_name":"University of Waikato","ror":"https://ror.org/013fsnh78","country_code":"NZ","type":"education","lineage":["https://openalex.org/I52179390"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Nicholas McGrath","raw_affiliation_strings":["School of Computing and Mathematics, University of Waikato, Hamilton, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing and Mathematics, University of Waikato, Hamilton, New Zealand","institution_ids":["https://openalex.org/I52179390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090758218","display_name":"Michael J. Cree","orcid":"https://orcid.org/0000-0002-2973-2710"},"institutions":[{"id":"https://openalex.org/I52179390","display_name":"University of Waikato","ror":"https://ror.org/013fsnh78","country_code":"NZ","type":"education","lineage":["https://openalex.org/I52179390"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Michael J. Cree","raw_affiliation_strings":["School of Engineering, University of Waikato, Hamilton, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering, University of Waikato, Hamilton, New Zealand","institution_ids":["https://openalex.org/I52179390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100405124","display_name":"Yifan Chen","orcid":"https://orcid.org/0000-0001-7645-623X"},"institutions":[{"id":"https://openalex.org/I52179390","display_name":"University of Waikato","ror":"https://ror.org/013fsnh78","country_code":"NZ","type":"education","lineage":["https://openalex.org/I52179390"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Yifan Chen","raw_affiliation_strings":["School of Engineering and the School of Computing and Mathematics, University of Waikato, Hamilton, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering and the School of Computing and Mathematics, University of Waikato, Hamilton, New Zealand","institution_ids":["https://openalex.org/I52179390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52179390"],"apc_list":null,"apc_paid":null,"fwci":2.7063,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.90606697,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"60","issue":null,"first_page":"378","last_page":"381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homing","display_name":"Homing (biology)","score":0.7200788259506226},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5397632122039795},{"id":"https://openalex.org/keywords/vascular-network","display_name":"Vascular network","score":0.4115602374076843},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2069305181503296},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11906573176383972},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.09688487648963928},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.062329500913619995}],"concepts":[{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.7200788259506226},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5397632122039795},{"id":"https://openalex.org/C3019347889","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Vascular network","level":2,"score":0.4115602374076843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2069305181503296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11906573176383972},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.09688487648963928},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.062329500913619995}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc44109.2020.9176014","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9176014","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33018007","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33018007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1980936120","https://openalex.org/W2100148774","https://openalex.org/W2104903940","https://openalex.org/W2121421529","https://openalex.org/W2140741294","https://openalex.org/W2145013849","https://openalex.org/W2156264000","https://openalex.org/W2559199060","https://openalex.org/W2605330351","https://openalex.org/W2924849247","https://openalex.org/W2956328734","https://openalex.org/W2963874589","https://openalex.org/W2979798121","https://openalex.org/W4285719527","https://openalex.org/W6681386923","https://openalex.org/W6730213019"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2146830435","https://openalex.org/W2013044847","https://openalex.org/W2589107051","https://openalex.org/W2383567523","https://openalex.org/W2329076138","https://openalex.org/W2358209849","https://openalex.org/W2042998709","https://openalex.org/W3030093879"],"abstract_inverted_index":{"Inspired":[0],"by":[1,32],"the":[2,6,50,59,78,87,129,147,156],"collaborative":[3],"movements":[4],"of":[5,52,131,155],"living":[7],"cells":[8],"in":[9,26,49,58,116],"different":[10],"natural":[11],"biological":[12],"processes,":[13],"this":[14],"paper":[15],"highlights":[16],"a":[17],"self-regulated":[18,139],"and":[19,37,47,81,124],"co-ordinated":[20],"targeting":[21],"strategy":[22],"to":[23,104],"detect":[24,105,146],"tumor":[25,60,65,76,148],"complex":[27],"human":[28],"vasculature.":[29],"We":[30,109],"show":[31],"computational":[33],"experiments":[34],"that":[35,111],"simple":[36],"non-centralized":[38,123],"nanoparticles":[39,68,140],"with":[40,98],"limited":[41,99],"locomotive":[42],"capability,":[43],"when":[44,153],"they":[45],"collaborate":[46],"move":[48],"form":[51],"groups,":[53],"can":[54,72,101,145],"be":[55,102],"very":[56],"robust":[57],"homing":[61],"process.":[62],"Once":[63],"reaching":[64],"location,":[66],"such":[67,137],"(potential":[69],"contrast":[70,135,141],"agents)":[71],"deposit":[73],"themselves":[74],"on":[75],"through":[77,120,134],"enhanced":[79,142],"permeability":[80],"retention":[82],"(EPR)":[83],"effect":[84],"thereby":[85],"making":[86],"malignant":[88,107],"cancerous":[89],"area":[90],"more":[91],"prominent.":[92],"Hence,":[93],"existing":[94],"medical":[95,143],"imaging":[96,144],"techniques":[97],"resolution":[100],"used":[103],"small":[106],"tumors.":[108],"believe":[110],"our":[112],"work":[113],"will":[114],"help":[115,130],"early":[117],"cancer":[118],"detection":[119],"an":[121],"independent,":[122],"self-controlled":[125],"system.Clinical":[126],"Relevance:-":[127],"With":[128],"target":[132],"amplification":[133],"agents":[136],"as":[138],"at":[149],"its":[150],"initial":[151],"stages":[152],"90%":[154],"cancers":[157],"are":[158],"curable.":[159]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2020-09-08T00:00:00"}
