{"id":"https://openalex.org/W3082516707","doi":"https://doi.org/10.1109/embc44109.2020.9175974","title":"Single-axon level automatic segmentation and feature extraction from immuhistochemical images of peripheral nerves","display_name":"Single-axon level automatic segmentation and feature extraction from immuhistochemical images of peripheral nerves","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3082516707","doi":"https://doi.org/10.1109/embc44109.2020.9175974","mag":"3082516707","pmid":"https://pubmed.ncbi.nlm.nih.gov/33018362"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9175974","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9175974","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071990522","display_name":"Viktor T\u00f3th","orcid":"https://orcid.org/0000-0002-3730-1400"},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Viktor Toth","raw_affiliation_strings":["Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA"],"affiliations":[{"raw_affiliation_string":"Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018204546","display_name":"Naveen Jayaprakash","orcid":"https://orcid.org/0000-0002-9466-5745"},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naveen Jayaprakash","raw_affiliation_strings":["Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA"],"affiliations":[{"raw_affiliation_string":"Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082653299","display_name":"Adam Abbas","orcid":"https://orcid.org/0000-0002-6145-5426"},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Abbas","raw_affiliation_strings":["Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA"],"affiliations":[{"raw_affiliation_string":"Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009515532","display_name":"Ariba Khan","orcid":null},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariba Khan","raw_affiliation_strings":["Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA"],"affiliations":[{"raw_affiliation_string":"Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016254801","display_name":"Stavros Zanos","orcid":"https://orcid.org/0000-0002-3967-8164"},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stavros Zanos","raw_affiliation_strings":["Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA"],"affiliations":[{"raw_affiliation_string":"Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068492860","display_name":"Theodoros P. Zanos","orcid":"https://orcid.org/0000-0002-9204-9551"},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodoros P. Zanos","raw_affiliation_strings":["Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA"],"affiliations":[{"raw_affiliation_string":"Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, Manhasset, NY, USA","institution_ids":["https://openalex.org/I1327576362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5071990522"],"corresponding_institution_ids":["https://openalex.org/I1327576362"],"apc_list":null,"apc_paid":null,"fwci":0.3667,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61784799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"40","issue":null,"first_page":"1859","last_page":"1862"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fascicle","display_name":"Fascicle","score":0.8610197305679321},{"id":"https://openalex.org/keywords/axon","display_name":"Axon","score":0.6813133955001831},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.644371747970581},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6220735311508179},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4974413216114044},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4927361309528351},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.46792104840278625},{"id":"https://openalex.org/keywords/interfacing","display_name":"Interfacing","score":0.45470955967903137},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.43943560123443604},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4193831980228424},{"id":"https://openalex.org/keywords/peripheral","display_name":"Peripheral","score":0.4144231677055359},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.35947614908218384},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2226940393447876}],"concepts":[{"id":"https://openalex.org/C110537703","wikidata":"https://www.wikidata.org/wiki/Q5436639","display_name":"Fascicle","level":2,"score":0.8610197305679321},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.6813133955001831},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.644371747970581},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6220735311508179},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4974413216114044},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4927361309528351},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.46792104840278625},{"id":"https://openalex.org/C2776303644","wikidata":"https://www.wikidata.org/wiki/Q1020499","display_name":"Interfacing","level":2,"score":0.45470955967903137},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.43943560123443604},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4193831980228424},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.4144231677055359},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.35947614908218384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2226940393447876},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc44109.2020.9175974","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9175974","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33018362","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33018362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1546503963","https://openalex.org/W1599114047","https://openalex.org/W1971482087","https://openalex.org/W2063773170","https://openalex.org/W2111732445","https://openalex.org/W2120723181","https://openalex.org/W2148432454","https://openalex.org/W2469268362","https://openalex.org/W2519728469","https://openalex.org/W2800689952","https://openalex.org/W2913564854","https://openalex.org/W2915081547","https://openalex.org/W2955659808","https://openalex.org/W2956987940","https://openalex.org/W2991241231","https://openalex.org/W2994831114","https://openalex.org/W3098938371","https://openalex.org/W4300672471"],"related_works":["https://openalex.org/W2131735617","https://openalex.org/W2373006798","https://openalex.org/W2532775738","https://openalex.org/W2005476934","https://openalex.org/W3197541072","https://openalex.org/W2045844866","https://openalex.org/W2142048117","https://openalex.org/W3175271736","https://openalex.org/W2129088621","https://openalex.org/W3037651061"],"abstract_inverted_index":{"Quantitative":[0],"descriptions":[1],"of":[2,7,15,31,63,82,88,101,109,112,119,125,128],"the":[3,13,19,41,67,99,113,117,126],"morphology":[4],"and":[5,24,75,85,124],"structure":[6],"peripheral":[8,64],"nerves":[9,65],"is":[10],"central":[11],"in":[12,59],"development":[14],"bioelectronic":[16],"devices":[17],"interfacing":[18],"nerves.":[20],"While":[21],"histological":[22],"procedures":[23],"microscopy":[25],"techniques":[26],"yield":[27],"high-resolution":[28],"detailed":[29],"images":[30,62,108],"individual":[32],"axons,":[33],"automated":[34],"methods":[35],"to":[36],"extract":[37],"relevant":[38],"information":[39],"at":[40,66],"single-axon":[42,120],"level":[43],"are":[44],"not":[45],"widely":[46],"available.":[47],"We":[48,97],"implemented":[49],"a":[50,92],"segmentation":[51],"algorithm":[52,103],"that":[53],"allows":[54],"for":[55],"subsequent":[56],"feature":[57],"extraction":[58],"immunohistochemistry":[60],"(IHC)":[61],"single":[68,89],"fiber":[69,129],"scale.":[70],"These":[71],"features":[72],"include":[73],"short":[74],"long":[76],"cross-sectional":[77],"diameters,":[78],"area,":[79],"perimeter,":[80],"thickness":[81],"surrounding":[83],"myelin":[84],"polar":[86],"coordinates":[87],"axons":[90],"within":[91],"nerve":[93,95],"or":[94],"fascicle.":[96],"evaluated":[98],"performance":[100],"our":[102],"using":[104],"manually":[105],"annotated":[106],"IHC":[107],"27":[110],"fascicles":[111],"swine":[114],"cervical":[115],"vagus;":[116],"accuracy":[118],"detection":[121],"was":[122,131],"82%,":[123],"classification":[127],"myelination":[130],"89%.":[132]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}