{"id":"https://openalex.org/W3082530903","doi":"https://doi.org/10.1109/embc44109.2020.9175820","title":"Assessment of Objectively Measured Physical Activity as an Independent Estimator of Functional Status in Clinical Trials","display_name":"Assessment of Objectively Measured Physical Activity as an Independent Estimator of Functional Status in Clinical Trials","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3082530903","doi":"https://doi.org/10.1109/embc44109.2020.9175820","mag":"3082530903","pmid":"https://pubmed.ncbi.nlm.nih.gov/33018861"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9175820","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9175820","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042494738","display_name":"Rub\u00e9n Buend\u00eda","orcid":"https://orcid.org/0000-0001-8126-9922"},"institutions":[{"id":"https://openalex.org/I4210116875","display_name":"AstraZeneca (Brazil)","ror":"https://ror.org/026m9xy48","country_code":"BR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210116875"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ruben Buendia","raw_affiliation_strings":["Astra Zeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astra Zeneca","institution_ids":["https://openalex.org/I4210116875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027488591","display_name":"Halsey Lea","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116875","display_name":"AstraZeneca (Brazil)","ror":"https://ror.org/026m9xy48","country_code":"BR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210116875"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Halsey Lea","raw_affiliation_strings":["Astra Zeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astra Zeneca","institution_ids":["https://openalex.org/I4210116875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100335372","display_name":"Bo Zhang","orcid":"https://orcid.org/0000-0003-2162-7446"},"institutions":[{"id":"https://openalex.org/I4210116875","display_name":"AstraZeneca (Brazil)","ror":"https://ror.org/026m9xy48","country_code":"BR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210116875"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bo Zhang","raw_affiliation_strings":["Astra Zeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astra Zeneca","institution_ids":["https://openalex.org/I4210116875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055926622","display_name":"Jesper Havsol","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116875","display_name":"AstraZeneca (Brazil)","ror":"https://ror.org/026m9xy48","country_code":"BR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210116875"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jesper Havsol","raw_affiliation_strings":["Astra Zeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astra Zeneca","institution_ids":["https://openalex.org/I4210116875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016894767","display_name":"Faisal M. Khan","orcid":"https://orcid.org/0000-0002-5116-7471"},"institutions":[{"id":"https://openalex.org/I4210116875","display_name":"AstraZeneca (Brazil)","ror":"https://ror.org/026m9xy48","country_code":"BR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210116875"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Faisal M. Khan","raw_affiliation_strings":["Astra Zeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astra Zeneca","institution_ids":["https://openalex.org/I4210116875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085466252","display_name":"Henrik Sill\u00e9n","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116875","display_name":"AstraZeneca (Brazil)","ror":"https://ror.org/026m9xy48","country_code":"BR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210116875"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Henrik Sillen","raw_affiliation_strings":["Astra Zeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astra Zeneca","institution_ids":["https://openalex.org/I4210116875"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074671302","display_name":"Glynn Dennis","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116875","display_name":"AstraZeneca (Brazil)","ror":"https://ror.org/026m9xy48","country_code":"BR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210116875"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Glynn Dennis","raw_affiliation_strings":["Astra Zeneca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astra Zeneca","institution_ids":["https://openalex.org/I4210116875"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210116875"],"apc_list":null,"apc_paid":null,"fwci":0.7767,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.74409183,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"2020","issue":null,"first_page":"3936","last_page":"3939"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12279","display_name":"Body Composition Measurement Techniques","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.5708012580871582},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"Physical therapy","score":0.5582836866378784},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.507082462310791},{"id":"https://openalex.org/keywords/physical-activity","display_name":"Physical activity","score":0.490792840719223},{"id":"https://openalex.org/keywords/test","display_name":"Test (biology)","score":0.4869428873062134},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.47428327798843384},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13796105980873108}],"concepts":[{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5708012580871582},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5582836866378784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.507082462310791},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.490792840719223},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.4869428873062134},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.47428327798843384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13796105980873108},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016552","descriptor_name":"Ergometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016552","descriptor_name":"Ergometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016552","descriptor_name":"Ergometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc44109.2020.9175820","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9175820","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33018861","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33018861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1993004659","https://openalex.org/W2107578220","https://openalex.org/W2168639577","https://openalex.org/W2213926659","https://openalex.org/W2535547710","https://openalex.org/W2582136236","https://openalex.org/W2605626004","https://openalex.org/W2738924919","https://openalex.org/W2750520206","https://openalex.org/W2921763239","https://openalex.org/W4246147341","https://openalex.org/W4292024189","https://openalex.org/W4295306962","https://openalex.org/W4365787138"],"related_works":["https://openalex.org/W4393234404","https://openalex.org/W641782856","https://openalex.org/W2330369487","https://openalex.org/W2906196243","https://openalex.org/W4385765419","https://openalex.org/W4286209793","https://openalex.org/W24443521","https://openalex.org/W2399667542","https://openalex.org/W2471323292","https://openalex.org/W2465689495"],"abstract_inverted_index":{"Functional":[0],"status":[1,56,158],"of":[2,37,66,155,159,172],"patients":[3,160],"is":[4,16,26,62],"an":[5],"important":[6,175],"concept":[7],"in":[8,90,161],"clinical":[9,81,162,176],"trials.":[10],"It":[11],"subsumes":[12],"functional":[13,23,76,157],"capacity,":[14],"which":[15,25],"traditionally":[17],"estimated":[18,28],"by":[19,29,35,129,137],"exercise":[20,132],"tests,":[21],"and":[22,50,59,71,106,118,131,174],"performance,":[24],"often":[27],"questionnaires.":[30],"Objectively":[31],"measured":[32,96,136],"physical":[33,55,124],"activity":[34,125],"means":[36],"wearables":[38],"devices":[39],"containing":[40],"accelerometers":[41],"(PA)":[42],"have":[43],"recently":[44],"been":[45],"proposed":[46],"as":[47,127,135,164,179],"a":[48,98,152],"novel":[49],"advantageous":[51],"way":[52],"to":[53,74,101],"estimate":[54,75],"including":[57],"capacity":[58],"performance.":[60],"There":[61],"nonetheless":[63],"insufficient":[64],"evidence":[65],"the":[67,79,112,138,156],"association":[68],"between":[69],"PA":[70,94],"traditional":[72],"ways":[73],"status.":[77],"In":[78],"ACTIVATE":[80],"trial,":[82],"cycle":[83,103,139],"ergometry":[84,104,140],"tests":[85,117],"were":[86,108],"performed":[87],"multiple":[88],"times":[89],"all":[91,146],"267":[92],"patients,":[93],"was":[95],"for":[97],"week":[99],"prior":[100],"each":[102,166],"test,":[105,141],"questionnaires":[107],"answered":[109],"daily":[110],"during":[111],"same":[113],"week.":[114],"Pearson's":[115],"correlation":[116],"clustering":[119],"analysis":[120],"revealed":[121],"that":[122],"PA,":[123],"experience":[126],"assessed":[128],"questionnaires,":[130],"endurance":[133],"time":[134],"are":[142,182],"largely":[143],"independent.":[144],"Therefore,":[145],"three":[147],"approaches":[148],"together":[149],"might":[150],"achieve":[151],"complete":[153],"assessment":[154],"trials,":[163],"they":[165],"independently":[167],"correlate":[168],"with":[169],"health-related":[170],"quality":[171],"life":[173],"outcomes":[177],"such":[178],"hospitalizations":[180],"but":[181],"weakly":[183],"associated":[184],"among":[185],"themselves.":[186]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}