{"id":"https://openalex.org/W3082904908","doi":"https://doi.org/10.1109/embc44109.2020.9175637","title":"Do cognitive reserve levels affect brain glucose metabolism and amyloid-\u03b2 depositions in subjective cognitive decline subjects?","display_name":"Do cognitive reserve levels affect brain glucose metabolism and amyloid-\u03b2 depositions in subjective cognitive decline subjects?","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3082904908","doi":"https://doi.org/10.1109/embc44109.2020.9175637","mag":"3082904908","pmid":"https://pubmed.ncbi.nlm.nih.gov/33018342"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9175637","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9175637","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100605296","display_name":"Chunhua Liu","orcid":"https://orcid.org/0009-0009-4849-2378"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhua Liu","raw_affiliation_strings":["Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019198680","display_name":"Guanquan Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanquan Chen","raw_affiliation_strings":["Center of Alzheimer\u2019s Disease, Institute for Brain Disorders, Beijing, China","Center of Alzheimer's Disease, Institute for Brain Disorders, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Alzheimer\u2019s Disease, Institute for Brain Disorders, Beijing, China","institution_ids":["https://openalex.org/I4210115644"]},{"raw_affiliation_string":"Center of Alzheimer's Disease, Institute for Brain Disorders, Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006099594","display_name":"Ying Han","orcid":"https://orcid.org/0009-0005-0822-8581"},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Han","raw_affiliation_strings":["Center of Alzheimer\u2019s Disease, Institute for Brain Disorders, Beijing, China","Center of Alzheimer's Disease, Institute for Brain Disorders, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Alzheimer\u2019s Disease, Institute for Brain Disorders, Beijing, China","institution_ids":["https://openalex.org/I4210115644"]},{"raw_affiliation_string":"Center of Alzheimer's Disease, Institute for Brain Disorders, Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081693785","display_name":"Jiehui Jiang","orcid":"https://orcid.org/0000-0003-4948-3683"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiehui Jiang","raw_affiliation_strings":["Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2020","issue":null,"first_page":"1775","last_page":"1778"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/affect","display_name":"Affect (linguistics)","score":0.7928825616836548},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"Cognitive decline","score":0.7041782140731812},{"id":"https://openalex.org/keywords/cognitive-reserve","display_name":"Cognitive reserve","score":0.6779932975769043},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.6287827491760254},{"id":"https://openalex.org/keywords/carbohydrate-metabolism","display_name":"Carbohydrate metabolism","score":0.4682881236076355},{"id":"https://openalex.org/keywords/amyloid","display_name":"Amyloid (mycology)","score":0.43928924202919006},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.43681207299232483},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3242151439189911},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3212894797325134},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"Cognitive impairment","score":0.3180382251739502},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3172628581523895},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.26210784912109375},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.21429488062858582},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.20618435740470886},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.17692908644676208},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.06736782193183899},{"id":"https://openalex.org/keywords/communication","display_name":"Communication","score":0.05491030216217041}],"concepts":[{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.7928825616836548},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.7041782140731812},{"id":"https://openalex.org/C67739388","wikidata":"https://www.wikidata.org/wiki/Q579471","display_name":"Cognitive reserve","level":4,"score":0.6779932975769043},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6287827491760254},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4682881236076355},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.43928924202919006},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.43681207299232483},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3242151439189911},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3212894797325134},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.3180382251739502},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3172628581523895},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.26210784912109375},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21429488062858582},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20618435740470886},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17692908644676208},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06736782193183899},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.05491030216217041}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058245","descriptor_name":"Cognitive Reserve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058245","descriptor_name":"Cognitive Reserve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058245","descriptor_name":"Cognitive Reserve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc44109.2020.9175637","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9175637","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:33018342","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33018342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1916193671","https://openalex.org/W1980111435","https://openalex.org/W2006114008","https://openalex.org/W2009946921","https://openalex.org/W2037794004","https://openalex.org/W2046024437","https://openalex.org/W2095849695","https://openalex.org/W2150504582","https://openalex.org/W2161117035","https://openalex.org/W2462655695","https://openalex.org/W2522995391","https://openalex.org/W2800051446","https://openalex.org/W2962822388","https://openalex.org/W4230705678","https://openalex.org/W7020950064"],"related_works":["https://openalex.org/W2168428585","https://openalex.org/W4293559774","https://openalex.org/W2005803286","https://openalex.org/W2969546739","https://openalex.org/W3088822227","https://openalex.org/W4385271147","https://openalex.org/W2107551763","https://openalex.org/W2076467171","https://openalex.org/W2037651195","https://openalex.org/W2346048686"],"abstract_inverted_index":{"Subjective":[0],"cognitive":[1,29],"decline":[2],"(SCD)":[3],"is":[4],"the":[5,43,153,166,173,207,213],"preclinical":[6],"stage":[7],"of":[8,136,168,176,192,216],"Alzheimer's":[9],"disease":[10],"(AD).":[11],"Abnormal":[12],"brain":[13],"glucose":[14,228],"metabolism":[15,229],"and":[16,53,71,97,118,142,158,218,230,239],"A\u03b2":[17,231],"depositions":[18],"can":[19],"be":[20,42],"observed":[21],"in":[22,32,35,149,179,195,234],"SCD":[23,54,235],"subjects.":[24,37],"Nevertheless,":[25],"there":[26,225],"was":[27,55,88,109,162,210],"not":[28],"impaired":[30],"performance":[31],"standardized":[33,130],"neuropsychological":[34],"these":[36],"Cognitive":[38],"reserve":[39],"(CR)":[40],"could":[41],"reason":[44],"to":[45,164],"explain":[46],"this":[47,59],"phenomenon.":[48],"However,":[49],"correspondence":[50],"between":[51,156,237],"CR":[52,160,241],"still":[56],"uncleared.":[57],"In":[58,205],"study,":[60],"we":[61,128],"attained":[62],"74":[63],"subjects":[64,236],"underwent":[65,74],"18FFDG":[66],"PET":[67,76,141,147],"scans":[68,77],"(SCD1":[69],"group)":[70,79],"38":[72],"patients":[73],"18FAV45":[75],"(SCD2":[78],"from":[80],"Xuanwu":[81],"Hospital,":[82],"Beijing,":[83],"China.":[84],"First,":[85],"SCD1":[86],"group":[87,108],"divided":[89,110],"into":[90,111],"SCD1H":[91,180],"(high":[92,113],"CR,":[93,100,114,121],"n=33,":[94],"educational":[95,102,116,123],"years>12)":[96,117],"SCD1L":[98,186],"(low":[99,120],"n=41,":[101],"years<;":[103,124],"=12)":[104,125],"groups.":[105,126,242],"The":[106,189],"SCD2":[107],"SCD2H":[112,196],"n=17,":[115],"SCD2L":[119,202],"n=21,":[122],"Second,":[127],"calculated":[129],"uptake":[131],"value":[132],"rate":[133],"(SUVR)":[134],"values":[135,175,191],"<sup":[137,143],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[138,144],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">18</sup>":[139,145],"FFDG":[140],"F-AV45":[146],"images":[148,178,194],"voxel-wise":[150],"level.":[151],"Third,":[152],"two-sample":[154],"t-test":[155],"low":[157,238],"high":[159,240],"groups":[161],"used":[163],"investigate":[165],"effects":[167],"CR.":[169],"As":[170,222],"a":[171,223],"result,":[172],"SUVR":[174,190],"FDG-PET":[177],"(0.89\u00b10.11)":[181],"were":[182,198],"significant":[183,199],"lower":[184,200],"than":[185,201],"(0.96\u00b10.13,":[187],"p=0.017).":[188],"AV45PET":[193],"(0.63\u00b10.11)":[197],"(0.78\u00b10.15,":[203],"p=0.001).":[204],"addition,":[206],"frontal":[208],"lobe":[209],"found":[211],"as":[212],"main":[214],"area":[215],"hypometabolism":[217],"reduced":[219],"AB":[220],"depositions.":[221],"conclusion,":[224],"are":[226],"differential":[227],"deposition":[232],"patterns":[233]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}