{"id":"https://openalex.org/W3082660139","doi":"https://doi.org/10.1109/embc44109.2020.9175271","title":"In Silico Cloning of Target Type 2 Diabetes Population for Treatments Development and Decision Support","display_name":"In Silico Cloning of Target Type 2 Diabetes Population for Treatments Development and Decision Support","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3082660139","doi":"https://doi.org/10.1109/embc44109.2020.9175271","mag":"3082660139"},"language":"en","primary_location":{"id":"doi:10.1109/embc44109.2020.9175271","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9175271","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022115669","display_name":"R. Visentin","orcid":"https://orcid.org/0000-0002-5848-5990"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Roberto Visentin","raw_affiliation_strings":["Department of Information Engineering, University of Padova, Padova, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Padova, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046700628","display_name":"Michele Schiavon","orcid":"https://orcid.org/0000-0003-0590-2399"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Schiavon","raw_affiliation_strings":["Department of Information Engineering, University of Padova, Padova, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Padova, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068823308","display_name":"Chiara Dalla Man","orcid":"https://orcid.org/0000-0002-4908-0596"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Dalla Man","raw_affiliation_strings":["Department of Information Engineering, University of Padova, Padova, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Padova, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022115669"],"corresponding_institution_ids":["https://openalex.org/I138689650"],"apc_list":null,"apc_paid":null,"fwci":0.4258,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.65386499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"5111","last_page":"5114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9891999959945679,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8354665040969849},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6871006488800049},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.678432822227478},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5131528973579407},{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.4629804193973541},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4126891791820526},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4057658016681671},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.37182846665382385},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3201504945755005},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2326143980026245},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12962788343429565},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11036255955696106},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.10774758458137512}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8354665040969849},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6871006488800049},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.678432822227478},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5131528973579407},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4629804193973541},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4126891791820526},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4057658016681671},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.37182846665382385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3201504945755005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2326143980026245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12962788343429565},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11036255955696106},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10774758458137512},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/embc44109.2020.9175271","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc44109.2020.9175271","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 42nd Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmh:oai:www.research.unipd.it:11577/3362944","is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/3362944","pdf_url":null,"source":{"id":"https://openalex.org/S4377196283","display_name":"Research Padua  Archive (University of Padua)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1965832529","https://openalex.org/W1969759774","https://openalex.org/W2000397529","https://openalex.org/W2050756416","https://openalex.org/W2084134947","https://openalex.org/W2099719924","https://openalex.org/W2106881342","https://openalex.org/W2145265693","https://openalex.org/W2154391117","https://openalex.org/W2160873546","https://openalex.org/W2163276087","https://openalex.org/W2207883647","https://openalex.org/W2473968961","https://openalex.org/W2520537712","https://openalex.org/W2572287943","https://openalex.org/W2606506153","https://openalex.org/W2790915589","https://openalex.org/W2907081153","https://openalex.org/W2913964535","https://openalex.org/W3019745372"],"related_works":["https://openalex.org/W3129816939","https://openalex.org/W2912862995","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W2003194288","https://openalex.org/W391093122","https://openalex.org/W1521239975","https://openalex.org/W4361305867"],"abstract_inverted_index":{"Therapies":[0],"for":[1,97,133],"treatment":[2,38],"of":[3,11,17,45,48,81,83,90,156,170,179],"type":[4],"2":[5],"diabetes":[6],"(T2D)":[7],"involve":[8],"a":[9,46,95,146],"variety":[10],"medications,":[12],"depending":[13],"on":[14,68],"the":[15,49,79,84,99,116,131,137,142,150,154],"stage":[16],"T2D":[18,41,61,70,104,158],"progression.":[19],"It":[20],"is":[21],"now":[22],"an":[23,53,173],"accepted":[24],"knowledge":[25],"that":[26],"in":[27,54,60,136,175],"silico":[28,55,176],"trials":[29],"can":[30,164],"help":[31],"to":[32,86,101,118,120,129,152,167],"accelerate":[33],"drug":[34],"development":[35],"and":[36,52,122],"support":[37],"optimization.":[39],"A":[40],"simulator":[42,85],"(T2DS),":[43],"consisting":[44],"model":[47],"glucose-insulin":[50,58],"system":[51],"population":[56],"describing":[57],"dynamics":[59],"subjects,":[62],"has":[63],"been":[64],"recently":[65],"developed":[66],"based":[67],"early-stage":[69],"data,":[71],"studied":[72],"with":[73,112],"sophisticated":[74],"experimental":[75],"techniques.":[76],"This":[77,126],"limits":[78],"domain":[80],"validity":[82],"this":[87],"specific":[88],"sub-population":[89],"T2D.":[91],"Here":[92],"we":[93,144],"proposed":[94],"method":[96],"tuning":[98],"T2DS":[100,132,151],"any":[102],"desired":[103],"target":[105,138],"population,":[106],"e.g.":[107],"insulin-na\u00efve":[108,157],"(i.e.,":[109],"not":[110],"experienced":[111],"insulin)":[113],"patients,":[114],"without":[115],"need":[117],"resort":[119],"complex":[121],"expensive":[123],"clinical":[124],"studies.":[125],"will":[127],"allow":[128],"use":[130],"testing":[134,177],"treatments":[135,181],"population.":[139],"To":[140],"illustrate":[141],"methodology,":[143],"used":[145],"case":[147],"study:":[148],"extending":[149],"reproduce":[153],"behavior":[155],"subjects.":[159],"The":[160],"methodology":[161],"described":[162],"here":[163],"be":[165],"extended":[166],"other":[168],"stages":[169],"T2D,":[171],"allowing":[172],"extensive":[174],"phase":[178],"different":[180],"before":[182],"human":[183],"trials.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2020-09-08T00:00:00"}
