{"id":"https://openalex.org/W4389576869","doi":"https://doi.org/10.1109/embc40787.2023.10341082","title":"Early Prediction of Neonatal Sepsis From Synthetic Clinical Data Using Machine Learning","display_name":"Early Prediction of Neonatal Sepsis From Synthetic Clinical Data Using Machine Learning","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389576869","doi":"https://doi.org/10.1109/embc40787.2023.10341082","pmid":"https://pubmed.ncbi.nlm.nih.gov/38082722"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10341082","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10341082","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072262926","display_name":"Simon Lyra","orcid":"https://orcid.org/0000-0002-3842-6897"},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simon Lyra","raw_affiliation_strings":["RWTH Aachen University,Medical Information Technology, Helmholtz Institute for Biomedical Engineering,Aachen,Germany,52074"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University,Medical Information Technology, Helmholtz Institute for Biomedical Engineering,Aachen,Germany,52074","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093468160","display_name":"Jinyi Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jinyi Jin","raw_affiliation_strings":["RWTH Aachen University,Medical Information Technology, Helmholtz Institute for Biomedical Engineering,Aachen,Germany,52074"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University,Medical Information Technology, Helmholtz Institute for Biomedical Engineering,Aachen,Germany,52074","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060021065","display_name":"Steffen Leonhardt","orcid":"https://orcid.org/0000-0002-6898-6887"},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Leonhardt","raw_affiliation_strings":["RWTH Aachen University,Medical Information Technology, Helmholtz Institute for Biomedical Engineering,Aachen,Germany,52074"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University,Medical Information Technology, Helmholtz Institute for Biomedical Engineering,Aachen,Germany,52074","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110431379","display_name":"Markus L\u00fcken","orcid":null},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus L\u00fcken","raw_affiliation_strings":["RWTH Aachen University,Medical Information Technology, Helmholtz Institute for Biomedical Engineering,Aachen,Germany,52074"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RWTH Aachen University,Medical Information Technology, Helmholtz Institute for Biomedical Engineering,Aachen,Germany,52074","institution_ids":["https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I887968799"],"apc_list":null,"apc_paid":null,"fwci":8.8414,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.97710487,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"Sepsis","score":0.7635987997055054},{"id":"https://openalex.org/keywords/neonatal-sepsis","display_name":"Neonatal sepsis","score":0.6509824991226196},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.612938404083252},{"id":"https://openalex.org/keywords/intensive-care","display_name":"Intensive care","score":0.6002299785614014},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5401920080184937},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5150313377380371},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.5112428665161133},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.4651896059513092},{"id":"https://openalex.org/keywords/neonatal-intensive-care-unit","display_name":"Neonatal intensive care unit","score":0.4648999273777008},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34818530082702637},{"id":"https://openalex.org/keywords/pediatrics","display_name":"Pediatrics","score":0.30493617057800293},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13608357310295105}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7635987997055054},{"id":"https://openalex.org/C2775953899","wikidata":"https://www.wikidata.org/wiki/Q6993495","display_name":"Neonatal sepsis","level":3,"score":0.6509824991226196},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.612938404083252},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.6002299785614014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5401920080184937},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5150313377380371},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5112428665161133},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.4651896059513092},{"id":"https://openalex.org/C2777091541","wikidata":"https://www.wikidata.org/wiki/Q9008292","display_name":"Neonatal intensive care unit","level":2,"score":0.4648999273777008},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34818530082702637},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.30493617057800293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13608357310295105}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071074","descriptor_name":"Neonatal Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000071074","descriptor_name":"Neonatal Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000071074","descriptor_name":"Neonatal Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000071074","descriptor_name":"Neonatal Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000071074","descriptor_name":"Neonatal Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007363","descriptor_name":"Intensive Care Units, Neonatal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007363","descriptor_name":"Intensive Care Units, Neonatal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007363","descriptor_name":"Intensive Care Units, Neonatal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007363","descriptor_name":"Intensive Care Units, Neonatal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007363","descriptor_name":"Intensive Care Units, Neonatal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10341082","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10341082","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38082722","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38082722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6499999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2162800060","https://openalex.org/W2396881363","https://openalex.org/W2570037867","https://openalex.org/W2614986146","https://openalex.org/W2788388954","https://openalex.org/W2995282027","https://openalex.org/W3007853906","https://openalex.org/W3086295184","https://openalex.org/W3211782957","https://openalex.org/W4233102854","https://openalex.org/W4281630308","https://openalex.org/W4295185371"],"related_works":["https://openalex.org/W2790351610","https://openalex.org/W2084285252","https://openalex.org/W2599100125","https://openalex.org/W2960932982","https://openalex.org/W2599691982","https://openalex.org/W4237910207","https://openalex.org/W4386093070","https://openalex.org/W4256281119","https://openalex.org/W4206835407","https://openalex.org/W4250023956"],"abstract_inverted_index":{"Neonatal":[0],"sepsis":[1,48,116,167,188],"is":[2],"one":[3],"of":[4,34,47,138,149,154,165,179,187,194],"the":[5,16,24,35,110,132,135,177,185,191],"most":[6],"serious":[7],"complications":[8],"in":[9,65,197],"neonatal":[10,29,113,139,166,198],"intensive":[11,199],"care":[12,200],"units.":[13,201],"Due":[14],"to":[15,27,52,69,108,126,189],"often":[17],"immature":[18],"immune":[19],"system,":[20],"sepsis-related":[21],"comorbidities":[22],"are":[23,118,160],"major":[25],"contributors":[26],"increased":[28],"mortality.":[30],"The":[31,103],"rapid":[32],"progression":[33],"disease":[36],"makes":[37],"early":[38,45,163,192],"treatment":[39],"critical":[40],"for":[41,101,162,171,184],"patient":[42],"survival.":[43],"However,":[44],"diagnosis":[46,117,193],"remains":[49],"difficult":[50],"due":[51],"its":[53],"non-specific":[54],"symptoms.":[55],"In":[56,75],"recent":[57],"years,":[58],"Machine":[59,180],"Learning-based":[60,181],"techniques":[61],"have":[62],"been":[63],"used":[64,100],"various":[66],"medical":[67],"applications":[68],"predict":[70],"diseases":[71],"using":[72,168],"clinical":[73,93,129],"data.":[74,130],"this":[76],"work,":[77],"we":[78,121],"optimized":[79],"and":[80,97,151],"evaluated":[81],"four":[82],"prediction":[83,164,182],"models":[84,183],"with":[85,115],"different":[86],"architectural":[87],"concepts.":[88],"Two":[89],"public":[90],"datasets":[91],"containing":[92],"data":[94,105,114,137,170],"from":[95],"adults":[96],"neonates":[98],"were":[99,106,141,156],"training.":[102],"adult":[104],"collected":[107],"pre-train":[109],"models.":[111],"Since":[112],"very":[119],"limited,":[120],"propose":[122],"an":[123,152],"augmentation":[124],"method":[125],"generate":[127],"synthetic":[128],"For":[131],"final":[133],"evaluation,":[134],"real":[136],"patients":[140],"defined":[142],"as":[143],"a":[144],"test":[145],"set.":[146],"An":[147],"AUROC":[148],"0.91":[150],"AUPRC":[153],"0.38":[155],"obtained.":[157],"These":[158],"results":[159],"promising":[161],"artificial":[169],"augmentation.Clinical":[172],"relevance-":[173],"This":[174],"work":[175],"demonstrates":[176],"potential":[178],"detection":[186],"improve":[190],"life-threatening":[195],"conditions":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}