{"id":"https://openalex.org/W4389542919","doi":"https://doi.org/10.1109/embc40787.2023.10341001","title":"Predictive Modeling Of Alzheimer\u2019s Disease Prognosis Using Anatomical &amp; Diffusion MRI","display_name":"Predictive Modeling Of Alzheimer\u2019s Disease Prognosis Using Anatomical &amp; Diffusion MRI","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389542919","doi":"https://doi.org/10.1109/embc40787.2023.10341001","pmid":"https://pubmed.ncbi.nlm.nih.gov/38083439"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10341001","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10341001","pdf_url":"https://ieeexplore.ieee.org/ielx7/10339936/10339939/10341001.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/10339936/10339939/10341001.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103222277","display_name":"Nikita Goel","orcid":"https://orcid.org/0000-0002-7473-6219"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikita Goel","raw_affiliation_strings":["University of Southern California,Imaging Genetics Center, Mark &#x0026; Mary Stevens Neuroimaging &#x0026; Informatics Institute, Keck School of Medicine,Los Angeles,California,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California,Imaging Genetics Center, Mark &#x0026; Mary Stevens Neuroimaging &#x0026; Informatics Institute, Keck School of Medicine,Los Angeles,California,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017365268","display_name":"Sophia I. Thomopoulos","orcid":"https://orcid.org/0000-0002-0046-4070"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia I. Thomopoulos","raw_affiliation_strings":["University of Southern California,Imaging Genetics Center, Mark &#x0026; Mary Stevens Neuroimaging &#x0026; Informatics Institute, Keck School of Medicine,Los Angeles,California,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California,Imaging Genetics Center, Mark &#x0026; Mary Stevens Neuroimaging &#x0026; Informatics Institute, Keck School of Medicine,Los Angeles,California,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074576951","display_name":"Tamoghna Chattopadhyay","orcid":"https://orcid.org/0000-0002-3146-6845"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamoghna Chattopadhyay","raw_affiliation_strings":["University of Southern California,Imaging Genetics Center, Mark &#x0026; Mary Stevens Neuroimaging &#x0026; Informatics Institute, Keck School of Medicine,Los Angeles,California,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California,Imaging Genetics Center, Mark &#x0026; Mary Stevens Neuroimaging &#x0026; Informatics Institute, Keck School of Medicine,Los Angeles,California,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Thompson","raw_affiliation_strings":["University of Southern California,Imaging Genetics Center, Mark &#x0026; Mary Stevens Neuroimaging &#x0026; Informatics Institute, Keck School of Medicine,Los Angeles,California,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California,Imaging Genetics Center, Mark &#x0026; Mary Stevens Neuroimaging &#x0026; Informatics Institute, Keck School of Medicine,Los Angeles,California,USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":1.1584,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.85575911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9851999878883362,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.6213905811309814},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.6046832203865051},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5659295320510864},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"Cognitive decline","score":0.468340128660202},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4654102623462677},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.44367220997810364},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"Cognitive impairment","score":0.4333764612674713},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4289669990539551},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.3865155875682831},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3724363446235657},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.36732879281044006},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.20012915134429932}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6213905811309814},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.6046832203865051},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5659295320510864},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.468340128660202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4654102623462677},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.44367220997810364},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.4333764612674713},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4289669990539551},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3865155875682831},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3724363446235657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36732879281044006},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20012915134429932}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10341001","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10341001","pdf_url":"https://ieeexplore.ieee.org/ielx7/10339936/10339939/10341001.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38083439","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38083439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":{"id":"doi:10.1109/embc40787.2023.10341001","is_oa":true,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10341001","pdf_url":"https://ieeexplore.ieee.org/ielx7/10339936/10339939/10341001.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1562517826","display_name":null,"funder_award_id":"U01\u2010AG068057","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389542919.pdf","grobid_xml":"https://content.openalex.org/works/W4389542919.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1872034074","https://openalex.org/W1970684162","https://openalex.org/W2000292092","https://openalex.org/W2001648635","https://openalex.org/W2018935975","https://openalex.org/W2159122349","https://openalex.org/W2344968483","https://openalex.org/W2560584411","https://openalex.org/W2582524520","https://openalex.org/W2798054687","https://openalex.org/W2914209001","https://openalex.org/W3172097624","https://openalex.org/W4210975612","https://openalex.org/W4226203773","https://openalex.org/W4241074797"],"related_works":["https://openalex.org/W2409059799","https://openalex.org/W364817481","https://openalex.org/W1972242255","https://openalex.org/W2890927416","https://openalex.org/W2775021631","https://openalex.org/W2128765271","https://openalex.org/W2966412519","https://openalex.org/W1481122508","https://openalex.org/W4390605164","https://openalex.org/W2208745537"],"abstract_inverted_index":{"Mild":[0],"cognitive":[1],"impairment":[2],"(MCI)":[3],"is":[4,17,43],"an":[5],"intermediate":[6],"stage":[7],"between":[8],"healthy":[9,124],"aging":[10],"and":[11,15,97,104,112,146],"Alzheimer's":[12],"disease":[13],"(AD),":[14],"AD":[16,31,41,56,80],"a":[18,58,85,138],"progressive":[19],"neurodegenerative":[20],"disorder":[21],"that":[22,76],"affects":[23],"around":[24],"50":[25],"million":[26],"people":[27],"worldwide.":[28],"As":[29],"new":[30],"treatments":[32],"begin":[33],"to":[34,44,53,55,78],"be":[35,70],"developed,":[36],"one":[37],"key":[38],"goal":[39],"of":[40,87,141,160],"research":[42],"predict":[45],"which":[46],"individuals":[47,68],"with":[48,127,164],"MCI":[49],"are":[50],"most":[51],"likely":[52],"progress":[54],"over":[57],"given":[59],"interval":[60],"(such":[61],"as":[62],"2":[63],"years);":[64],"if":[65],"successful,":[66],"these":[67],"could":[69],"preferentially":[71],"enrolled":[72],"in":[73],"drug":[74],"trials":[75],"aim":[77],"slow":[79],"progression.":[81],"Here":[82],"we":[83],"benchmarked":[84],"range":[86],"MCI-to-AD":[88],"predictive":[89],"models":[90,133],"including":[91,134],"linear":[92],"regressions,":[93],"support":[94],"vector":[95],"machines,":[96],"random":[98],"forests,":[99],"using":[100,148],"predictors":[101],"from":[102,129],"anatomical":[103],"diffusion-weighted":[105],"brain":[106],"MRI,":[107],"age,":[108],"sex,":[109],"APOE":[110],"genotype":[111],"standardized":[113],"clinical":[114],"scores.":[115],"In":[116],"evaluations":[117],"on":[118,152],"2,448":[119],"subjects":[120],"(1,132":[121],"MCI,":[122],"883":[123],"controls,":[125],"433":[126],"dementia)":[128],"the":[130,156],"ADNI":[131],"study,":[132],"PCA-compacted":[135],"features":[136],"achieved":[137],"balanced":[139],"accuracy":[140],"75.3%":[142],"(using":[143],"cortical":[144],"features)":[145],"89.7%":[147],"diffusion":[149,165],"MRI":[150],"measures":[151],"test":[153],"set,":[154],"suggesting":[155],"added":[157],"prognostic":[158],"value":[159],"microstructural":[161],"metrics":[162],"obtainable":[163],"MRI.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2023-12-12T00:00:00"}
