{"id":"https://openalex.org/W4389577016","doi":"https://doi.org/10.1109/embc40787.2023.10340830","title":"Changes in pelvic floor electrical activity and vulvar pain after botulinum toxin treatment of vestibulodynia: are clinical and electrophysiological outcomes related?<sup>*</sup>","display_name":"Changes in pelvic floor electrical activity and vulvar pain after botulinum toxin treatment of vestibulodynia: are clinical and electrophysiological outcomes related?<sup>*</sup>","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389577016","doi":"https://doi.org/10.1109/embc40787.2023.10340830","pmid":"https://pubmed.ncbi.nlm.nih.gov/38082636"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10340830","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10340830","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026992546","display_name":"Monica Albaladejo-Belmonte","orcid":"https://orcid.org/0000-0002-2099-4626"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Monica Albaladejo-Belmonte","raw_affiliation_strings":["Universitat Polit&#x00E8;nica de Val&#x00E8;ncia,Centro de Investigaci&#x00F3;n e Innovaci&#x00F3;n en Boingenier&#x00ED;a,Valencia,Spain"],"affiliations":[{"raw_affiliation_string":"Universitat Polit&#x00E8;nica de Val&#x00E8;ncia,Centro de Investigaci&#x00F3;n e Innovaci&#x00F3;n en Boingenier&#x00ED;a,Valencia,Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092549256","display_name":"Paula Villa-Mu\u00f1oz","orcid":null},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paula Villa-Mu\u00f1oz","raw_affiliation_strings":["Hospital Polit&#x00E8;cnic i Universitari La Fe,Servicio de Ginecolog&#x00ED;a y Obstetricia,Valencia,Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Polit&#x00E8;cnic i Universitari La Fe,Servicio de Ginecolog&#x00ED;a y Obstetricia,Valencia,Spain","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068516374","display_name":"Francisco J. Nohales-Alfonso","orcid":"https://orcid.org/0000-0001-6626-5472"},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco J. Nohales-Alfonso","raw_affiliation_strings":["Hospital Polit&#x00E8;cnic i Universitari La Fe,Servicio de Ginecolog&#x00ED;a y Obstetricia,Valencia,Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Polit&#x00E8;cnic i Universitari La Fe,Servicio de Ginecolog&#x00ED;a y Obstetricia,Valencia,Spain","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048033089","display_name":"Rogelio Monfort-Ort\u00edz","orcid":"https://orcid.org/0000-0001-7931-8609"},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rogelio Monfort-Ortiz","raw_affiliation_strings":["Hospital Polit&#x00E8;cnic i Universitari La Fe,Servicio de Ginecolog&#x00ED;a y Obstetricia,Valencia,Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Polit&#x00E8;cnic i Universitari La Fe,Servicio de Ginecolog&#x00ED;a y Obstetricia,Valencia,Spain","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093468269","display_name":"Juan Miguel Mira\u2010Tomas","orcid":"https://orcid.org/0009-0001-7899-4864"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Miguel Mira-Tomas","raw_affiliation_strings":["Universitat Polit&#x00E8;nica de Val&#x00E8;ncia,Centro de Investigaci&#x00F3;n e Innovaci&#x00F3;n en Boingenier&#x00ED;a,Valencia,Spain"],"affiliations":[{"raw_affiliation_string":"Universitat Polit&#x00E8;nica de Val&#x00E8;ncia,Centro de Investigaci&#x00F3;n e Innovaci&#x00F3;n en Boingenier&#x00ED;a,Valencia,Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034765381","display_name":"Jos\u00e9 Alberola-Rubio","orcid":"https://orcid.org/0000-0003-2112-7927"},"institutions":[{"id":"https://openalex.org/I4210138905","display_name":"Molecular Devices (United Kingdom)","ror":"https://ror.org/03y8xh662","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210138905","https://openalex.org/I4387152658"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jose Alberola-Rubio","raw_affiliation_strings":["Sonda Devices S.L.,Valencia,Spain","Sonda Devices S.L., Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Sonda Devices S.L.,Valencia,Spain","institution_ids":["https://openalex.org/I4210138905"]},{"raw_affiliation_string":"Sonda Devices S.L., Valencia, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068141518","display_name":"Javier Garcia\u2010Casado","orcid":"https://orcid.org/0000-0003-1410-2721"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javier Garcia-Casado","raw_affiliation_strings":["Universitat Polit&#x00E8;nica de Val&#x00E8;ncia,Centro de Investigaci&#x00F3;n e Innovaci&#x00F3;n en Boingenier&#x00ED;a,Valencia,Spain"],"affiliations":[{"raw_affiliation_string":"Universitat Polit&#x00E8;nica de Val&#x00E8;ncia,Centro de Investigaci&#x00F3;n e Innovaci&#x00F3;n en Boingenier&#x00ED;a,Valencia,Spain","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5026992546"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4604,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.66200241,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9628000259399414,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14220","display_name":"Workaholism, burnout, and well-being","score":0.9452000260353088,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pelvic-floor","display_name":"Pelvic floor","score":0.6444727182388306},{"id":"https://openalex.org/keywords/botulinum-toxin","display_name":"Botulinum toxin","score":0.6067888140678406},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.58474200963974},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5262773633003235},{"id":"https://openalex.org/keywords/pelvic-pain","display_name":"Pelvic pain","score":0.506348729133606},{"id":"https://openalex.org/keywords/vulvodynia","display_name":"Vulvodynia","score":0.48391562700271606},{"id":"https://openalex.org/keywords/dermatology","display_name":"Dermatology","score":0.41859710216522217},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.23601672053337097},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17512786388397217},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.17127537727355957}],"concepts":[{"id":"https://openalex.org/C2781244320","wikidata":"https://www.wikidata.org/wiki/Q813683","display_name":"Pelvic floor","level":2,"score":0.6444727182388306},{"id":"https://openalex.org/C2777478456","wikidata":"https://www.wikidata.org/wiki/Q208413","display_name":"Botulinum toxin","level":2,"score":0.6067888140678406},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.58474200963974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5262773633003235},{"id":"https://openalex.org/C2780136519","wikidata":"https://www.wikidata.org/wiki/Q7161805","display_name":"Pelvic pain","level":2,"score":0.506348729133606},{"id":"https://openalex.org/C2780549859","wikidata":"https://www.wikidata.org/wiki/Q1571008","display_name":"Vulvodynia","level":3,"score":0.48391562700271606},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.41859710216522217},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.23601672053337097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17512786388397217},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17127537727355957}],"mesh":[{"descriptor_ui":"D001905","descriptor_name":"Botulinum Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001905","descriptor_name":"Botulinum Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001905","descriptor_name":"Botulinum Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001905","descriptor_name":"Botulinum Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001905","descriptor_name":"Botulinum Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009424","descriptor_name":"Nervous System Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009424","descriptor_name":"Nervous System Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009424","descriptor_name":"Nervous System Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009424","descriptor_name":"Nervous System Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009424","descriptor_name":"Nervous System Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017773","descriptor_name":"Pelvic Floor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017773","descriptor_name":"Pelvic Floor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017773","descriptor_name":"Pelvic Floor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017773","descriptor_name":"Pelvic Floor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017773","descriptor_name":"Pelvic Floor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056650","descriptor_name":"Vulvodynia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D056650","descriptor_name":"Vulvodynia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D056650","descriptor_name":"Vulvodynia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D056650","descriptor_name":"Vulvodynia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D056650","descriptor_name":"Vulvodynia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D059952","descriptor_name":"Pelvic Floor Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059952","descriptor_name":"Pelvic Floor Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059952","descriptor_name":"Pelvic Floor Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059952","descriptor_name":"Pelvic Floor Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059952","descriptor_name":"Pelvic Floor Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10340830","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10340830","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38082636","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38082636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2069192856","https://openalex.org/W2086305700","https://openalex.org/W2282444394","https://openalex.org/W2309188086","https://openalex.org/W2803671091","https://openalex.org/W2810590727","https://openalex.org/W3047324632","https://openalex.org/W3137825942","https://openalex.org/W3166802531","https://openalex.org/W3177707283","https://openalex.org/W3194066735","https://openalex.org/W4211104100","https://openalex.org/W4311927313","https://openalex.org/W6695712422","https://openalex.org/W6734252006"],"related_works":["https://openalex.org/W182329240","https://openalex.org/W209158688","https://openalex.org/W2581703005","https://openalex.org/W2928099903","https://openalex.org/W3185620511","https://openalex.org/W2141672218","https://openalex.org/W627488549","https://openalex.org/W2244775409","https://openalex.org/W2740295392","https://openalex.org/W2495965195"],"abstract_inverted_index":{"Vestibulodynia":[0],"is":[1],"a":[2,119,209],"gynecological":[3],"condition":[4,191],"with":[5,57,68,83,181,194],"different":[6],"treatment":[7],"options":[8],"available,":[9],"including":[10],"botulinum":[11],"neurotoxin":[12],"type":[13],"A":[14],"(BoNT/A)":[15],"injections":[16],"into":[17],"the":[18,30,34,72,175,212],"vulvar":[19,60,89,146,185],"vestibule.":[20],"Unlike":[21],"other":[22],"treatments,":[23],"no":[24],"studies":[25],"have":[26],"assessed":[27],"changes":[28,52,58],"in":[29,59,174,184],"myoelectrical":[31,73],"activity":[32,74,177],"of":[33,44,75,125,157,192,214],"pelvic":[35],"floor":[36],"muscles":[37],"(PFM)":[38],"after":[39,106,152,201],"BoNT/A":[40,107,202],"treatment.":[41,108,153,203],"The":[42],"aim":[43],"this":[45],"study":[46,205],"was":[47,81,92],"thus":[48],"to":[49,54,95,110,198,208],"evaluate":[50],"these":[51],"and":[53,78,87,100,105,216],"correlate":[55],"them":[56],"pain":[61,90,147],"sensitivity.":[62],"To":[63],"do":[64],"this,":[65],"35":[66],"patients":[67,193],"vestibulodynia":[69,195],"were":[70,165,179],"recruited,":[71],"their":[76,88,133],"left":[77],"right":[79],"PFM":[80,116,160,176,189,217],"recorded":[82],"surface":[84],"electromyography":[85],"(sEMG),":[86],"sensitivity":[91],"monitored":[93],"according":[94],"Visual":[96],"Analogue":[97],"Scale":[98],"(VAS)":[99],"an":[101],"algometer,":[102],"both":[103],"before":[104],"According":[109],"our":[111],"results,":[112],"patients'":[113],"signals":[114],"during":[115],"relaxation":[117],"showed":[118],"significantly":[120,150,166],"higher":[121,172,182],"power":[122,178],"than":[123],"those":[124],"healthy":[126,199],"women":[127],"at":[128,142,159],"baseline,":[129],"as":[130],"shown":[131],"by":[132],"root":[134],"mean":[135,145,163],"square":[136],"values":[137],"(RMS),":[138],"but":[139],"became":[140],"similar":[141,197],"follow-up.":[143],"Patients'":[144],"VAS":[148,164],"scores":[149],"decreased":[151],"Furthermore,":[154],"baseline-to-follow-up":[155],"differences":[156],"RMS":[158],"rest":[161],"vs.":[162],"correlated":[167],"(CC=0.48,":[168],"p<0.01)":[169],"so":[170],"that":[171],"reductions":[173],"associated":[180],"decreases":[183],"pain.Clinical":[186],"Relevance-":[187],"Altered":[188],"electrophysiological":[190,218],"becomes":[196],"women's":[200],"This":[204],"also":[206],"points":[207],"relationship":[210],"between":[211],"evolution":[213],"clinical":[215],"conditions.":[219]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}