{"id":"https://openalex.org/W4389542892","doi":"https://doi.org/10.1109/embc40787.2023.10340798","title":"Cardiovascular response to closed-loop intraneural stimulation of the right vagus nerve: a proof-of-concept study *","display_name":"Cardiovascular response to closed-loop intraneural stimulation of the right vagus nerve: a proof-of-concept study *","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389542892","doi":"https://doi.org/10.1109/embc40787.2023.10340798","pmid":"https://pubmed.ncbi.nlm.nih.gov/38082815"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10340798","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340798","pdf_url":"https://ieeexplore.ieee.org/ielx7/10339936/10339939/10340798.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ieeexplore.ieee.org/ielx7/10339936/10339939/10340798.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047912053","display_name":"Ciro Zinno","orcid":"https://orcid.org/0000-0001-8873-8875"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Zinno","raw_affiliation_strings":["Scuola Superiore Sant’Anna,The BioRobotics Institute,Department of Excellence in Robotics & AI,Pisa,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola Superiore Sant’Anna,The BioRobotics Institute,Department of Excellence in Robotics & AI,Pisa,Italy","institution_ids":["https://openalex.org/I162290304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031070553","display_name":"Filippo Agnesi","orcid":"https://orcid.org/0000-0003-1780-8084"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Agnesi","raw_affiliation_strings":["Scuola Superiore Sant’Anna,The BioRobotics Institute,Department of Excellence in Robotics & AI,Pisa,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola Superiore Sant’Anna,The BioRobotics Institute,Department of Excellence in Robotics & AI,Pisa,Italy","institution_ids":["https://openalex.org/I162290304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079903363","display_name":"Fabio Bernini","orcid":null},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Bernini","raw_affiliation_strings":["Scuola Superiore Sant’Anna,BioMedLab,Pisa,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola Superiore Sant’Anna,BioMedLab,Pisa,Italy","institution_ids":["https://openalex.org/I162290304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064626414","display_name":"Khatia Gabisonia","orcid":"https://orcid.org/0000-0002-4981-3673"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"K. Gabisonia","raw_affiliation_strings":["Scuola Superiore Sant’Anna,BioMedLab,Pisa,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola Superiore Sant’Anna,BioMedLab,Pisa,Italy","institution_ids":["https://openalex.org/I162290304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081104945","display_name":"Domiziana Terlizzi","orcid":"https://orcid.org/0000-0002-4917-869X"},"institutions":[{"id":"https://openalex.org/I4210158339","display_name":"Fondazione Toscana Gabriele Monasterio","ror":"https://ror.org/058a2pj71","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210158339"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Terlizzi","raw_affiliation_strings":["Fondazione Toscana G. Monasterio,Pisa,Italy","Fondazione Toscana G. Monasterio, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione Toscana G. Monasterio,Pisa,Italy","institution_ids":["https://openalex.org/I4210158339"]},{"raw_affiliation_string":"Fondazione Toscana G. Monasterio, Pisa, Italy","institution_ids":["https://openalex.org/I4210158339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009822156","display_name":"Fabio A. Recchia","orcid":"https://orcid.org/0000-0002-4189-8465"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"F. A. Recchia","raw_affiliation_strings":["Scuola Superiore Sant'Anna,Pisa,Italy","Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America","Scuola Superiore Sant'Anna, Pisa, Italy","National Research Council, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola Superiore Sant'Anna,Pisa,Italy","institution_ids":["https://openalex.org/I162290304"]},{"raw_affiliation_string":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States of America","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Scuola Superiore Sant'Anna, Pisa, Italy","institution_ids":["https://openalex.org/I162290304"]},{"raw_affiliation_string":"National Research Council, Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005090268","display_name":"Vincenzo Lionetti","orcid":"https://orcid.org/0000-0002-0640-8651"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V. Lionetti","raw_affiliation_strings":["Scuola Superiore Sant'Anna,Unit of Translational Critical Care Medicine, Laboratory of Basic and Applied Medical Sciences, Interdisciplinary Research Center \"Health Science\", and BioMedLab,Pisa,Italy","Unit of Translational Critical Care Medicine, Laboratory of Basic and Applied Medical Sciences, Interdisciplinary Research Center \"Health Science\", and BioMedLab, Scuola Superiore Sant'Anna, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola Superiore Sant'Anna,Unit of Translational Critical Care Medicine, Laboratory of Basic and Applied Medical Sciences, Interdisciplinary Research Center \"Health Science\", and BioMedLab,Pisa,Italy","institution_ids":["https://openalex.org/I162290304"]},{"raw_affiliation_string":"Unit of Translational Critical Care Medicine, Laboratory of Basic and Applied Medical Sciences, Interdisciplinary Research Center \"Health Science\", and BioMedLab, Scuola Superiore Sant'Anna, Pisa, Italy","institution_ids":["https://openalex.org/I162290304"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080060929","display_name":"Silvestro Micera","orcid":"https://orcid.org/0000-0003-4396-8217"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Micera","raw_affiliation_strings":["Scuola Superiore Sant’Anna,The BioRobotics Institute,Department of Excellence in Robotics & AI,Pisa,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola Superiore Sant’Anna,The BioRobotics Institute,Department of Excellence in Robotics & AI,Pisa,Italy","institution_ids":["https://openalex.org/I162290304"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.114,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50193601,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vagus-nerve-stimulation","display_name":"Vagus nerve stimulation","score":0.9454934597015381},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6802126169204712},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.664292573928833},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.631129264831543},{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"Vagus nerve","score":0.5706745982170105},{"id":"https://openalex.org/keywords/closed-loop","display_name":"Closed loop","score":0.41374337673187256},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3980049192905426},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.24885013699531555},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.13023582100868225}],"concepts":[{"id":"https://openalex.org/C2780087125","wikidata":"https://www.wikidata.org/wiki/Q2062293","display_name":"Vagus nerve stimulation","level":4,"score":0.9454934597015381},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6802126169204712},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.664292573928833},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.631129264831543},{"id":"https://openalex.org/C2781404750","wikidata":"https://www.wikidata.org/wiki/Q190140","display_name":"Vagus nerve","level":3,"score":0.5706745982170105},{"id":"https://openalex.org/C3019251811","wikidata":"https://www.wikidata.org/wiki/Q5135346","display_name":"Closed loop","level":2,"score":0.41374337673187256},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3980049192905426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24885013699531555},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13023582100868225},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc40787.2023.10340798","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340798","pdf_url":"https://ieeexplore.ieee.org/ielx7/10339936/10339939/10340798.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38082815","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38082815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:infoscience.epfl.ch:309715","is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/206313","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WoS","raw_type":"conference proceedings"}],"best_oa_location":{"id":"doi:10.1109/embc40787.2023.10340798","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340798","pdf_url":"https://ieeexplore.ieee.org/ielx7/10339936/10339939/10340798.pdf","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.46000000834465027,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[{"id":"https://openalex.org/G3048673831","display_name":null,"funder_award_id":"824071","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4937468798","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5230436755","display_name":null,"funder_award_id":"824071","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G8140797641","display_name":null,"funder_award_id":"H2020-FETPROACT-2018-2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320324216","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389542892.pdf","grobid_xml":"https://content.openalex.org/works/W4389542892.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1963959347","https://openalex.org/W2012853348","https://openalex.org/W2021060449","https://openalex.org/W2028925130","https://openalex.org/W2060718012","https://openalex.org/W2065847542","https://openalex.org/W2116095873","https://openalex.org/W2170195027","https://openalex.org/W2337818477","https://openalex.org/W2397167071","https://openalex.org/W2552833391","https://openalex.org/W2613408503","https://openalex.org/W2624453644","https://openalex.org/W2766189809","https://openalex.org/W3002075194","https://openalex.org/W3092425259","https://openalex.org/W3127447029","https://openalex.org/W3163826257","https://openalex.org/W3171711893","https://openalex.org/W4205237820","https://openalex.org/W4205431456","https://openalex.org/W4285280279","https://openalex.org/W4316926648"],"related_works":["https://openalex.org/W4301397033","https://openalex.org/W4392298994","https://openalex.org/W2475049644","https://openalex.org/W2175322453","https://openalex.org/W2919512075","https://openalex.org/W4301396970","https://openalex.org/W2006689666","https://openalex.org/W3146991102","https://openalex.org/W2550683708","https://openalex.org/W4281649449"],"abstract_inverted_index":{"Vagus":[0],"nerve":[1,165],"stimulation":[2,127,177,247],"(VNS)":[3],"is":[4,76,98,108,120,134],"an":[5,87],"FDA-approved":[6],"technique":[7],"for":[8,64,225],"the":[9,12,47,60,65,84,101,105,126,148,154,179,195,199,221,226,233],"neuromodulation":[10],"of":[11,50,67,95,104,113,128,150,163,178,198,228,235,244],"autonomic":[13],"nervous":[14],"system.":[15],"There":[16],"are":[17,40,46],"many":[18],"therapeutic":[19],"applications":[20,39],"where":[21],"VNS":[22,53,75,224],"could":[23],"be":[24],"used":[25],"as":[26,30,209],"a":[27,79,111,117,160,174,184,210,215,241],"therapy,":[28],"such":[29],"cardiovascular":[31,44,229],"diseases,":[32],"epilepsy,":[33],"depression,":[34],"and":[35,167,231,248],"inflammatory":[36],"conditions.":[37],"Cardiovascular":[38],"particularly":[41],"relevant,":[42],"since":[43],"diseases":[45],"top":[48],"causes":[49],"death":[51],"worldwide.":[52],"clinical":[54],"trials":[55],"have":[56],"been":[57],"performed":[58],"in":[59,86,110,183,246],"last":[61],"15":[62],"years":[63],"treatment":[66,227],"heart":[68],"failure":[69],"(HF),":[70],"achieving":[71],"controversial":[72],"results.":[73],"Typically":[74],"applied":[77],"with":[78,159,240],"cuff":[80],"electrode":[81],"placed":[82],"around":[83],"nerve,":[85],"open-loop":[88],"or":[89],"cardiac":[90],"synchronized":[91],"design.":[92],"The":[93,189],"effectiveness":[94],"this":[96],"approach":[97],"hindered":[99],"by":[100,136],"multifunctional":[102],"nature":[103],"VN,":[106],"which":[107,139],"involved":[109],"variety":[112],"homeostatic":[114],"controls.":[115],"When":[116],"high":[118,242],"current":[119,152],"applied,":[121],"adverse":[122],"effects":[123],"arise":[124],"from":[125],"undesired":[129],"fibers.":[130],"An":[131],"alternative":[132],"strategy":[133],"represented":[135],"intraneural":[137,176,190,223],"stimulation,":[138],"can":[140],"guarantee":[141],"higher":[142],"selectivity.":[143],"Moreover,":[144],"closed-loop":[145,175,203,222],"modalities":[146],"allow":[147],"delivery":[149],"electrical":[151],"inside":[153],"nerves":[155],"only":[156],"if":[157],"needed,":[158],"reduced":[161],"risk":[162],"untargeted":[164],"activation":[166],"lower":[168],"energy":[169],"consumption.":[170],"Here":[171],"we":[172],"propose":[173],"right":[180],"cervical":[181],"VN":[182],"clinically":[185],"relevant":[186],"animal":[187],"model.":[188],"was":[191,205],"designed":[192],"according":[193],"to":[194,213],"internal":[196],"structure":[197],"VN.":[200],"A":[201],"threshold-based":[202],"algorithm":[204],"developed":[206],"using":[207],"HR":[208],"control":[211],"variable":[212],"produce":[214],"chronotropic":[216],"effect.Clinical":[217],"Relevance-This":[218],"work":[219],"analyzes":[220],"disorders,":[230],"supports":[232],"possibility":[234],"developing":[236],"fully":[237],"implantable":[238],"devices":[239],"degree":[243],"selectivity":[245],"prolonged":[249],"lifespan.":[250]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}