{"id":"https://openalex.org/W4389577019","doi":"https://doi.org/10.1109/embc40787.2023.10340655","title":"Robustness of Optimal Circadian Rhythm Entrainment under Model Perturbation","display_name":"Robustness of Optimal Circadian Rhythm Entrainment under Model Perturbation","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389577019","doi":"https://doi.org/10.1109/embc40787.2023.10340655","pmid":"https://pubmed.ncbi.nlm.nih.gov/38083597"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10340655","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340655","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101278134","display_name":"Zidi Tao","orcid":null},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zidi Tao","raw_affiliation_strings":["Rensselaer Polytechnic Institute,Computer, and Systems Engineering,Department of Electrical,Troy,NY,USA,12180"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rensselaer Polytechnic Institute,Computer, and Systems Engineering,Department of Electrical,Troy,NY,USA,12180","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029921181","display_name":"A. Agung Julius","orcid":"https://orcid.org/0000-0002-0970-3226"},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agung Julius","raw_affiliation_strings":["Rensselaer Polytechnic Institute,Computer, and Systems Engineering,Department of Electrical,Troy,NY,USA,12180"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rensselaer Polytechnic Institute,Computer, and Systems Engineering,Department of Electrical,Troy,NY,USA,12180","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074830403","display_name":"John T. Wen","orcid":"https://orcid.org/0000-0002-5123-5411"},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Wen","raw_affiliation_strings":["Rensselaer Polytechnic Institute,Computer, and Systems Engineering,Department of Electrical,Troy,NY,USA,12180"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rensselaer Polytechnic Institute,Computer, and Systems Engineering,Department of Electrical,Troy,NY,USA,12180","institution_ids":["https://openalex.org/I165799507"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165799507"],"apc_list":null,"apc_paid":null,"fwci":4.7917,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.95614035,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11963","display_name":"Impact of Light on Environment and Health","score":0.9757999777793884,"subfield":{"id":"https://openalex.org/subfields/2306","display_name":"Global and Planetary Change"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.9301000237464905,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/entrainment","display_name":"Entrainment (biomusicology)","score":0.7721872329711914},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"Circadian rhythm","score":0.6792474985122681},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6750462055206299},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5385825037956238},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.5156439542770386},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.4666701853275299},{"id":"https://openalex.org/keywords/rhythm","display_name":"Rhythm","score":0.44781872630119324},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.15551355481147766},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.15510022640228271},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1441660225391388},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13872435688972473},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.127542644739151},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.08905792236328125},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08544445037841797}],"concepts":[{"id":"https://openalex.org/C139992725","wikidata":"https://www.wikidata.org/wiki/Q5380656","display_name":"Entrainment (biomusicology)","level":3,"score":0.7721872329711914},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.6792474985122681},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6750462055206299},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5385825037956238},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.5156439542770386},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.4666701853275299},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.44781872630119324},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.15551355481147766},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15510022640228271},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1441660225391388},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13872435688972473},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.127542644739151},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08905792236328125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08544445037841797},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10340655","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/embc40787.2023.10340655","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38083597","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38083597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5699999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320316514","display_name":"Arm","ror":"https://ror.org/04mmhzs81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2024157935","https://openalex.org/W2048323960","https://openalex.org/W2075396624","https://openalex.org/W2118809524","https://openalex.org/W2135303822","https://openalex.org/W2145348595","https://openalex.org/W2325295812","https://openalex.org/W2327238836","https://openalex.org/W2996037132","https://openalex.org/W3082036007"],"related_works":["https://openalex.org/W4251219350","https://openalex.org/W1981959626","https://openalex.org/W2000399986","https://openalex.org/W1991385098","https://openalex.org/W3206121223","https://openalex.org/W2142086688","https://openalex.org/W2279228672","https://openalex.org/W2016153726","https://openalex.org/W2559880748","https://openalex.org/W3065977955"],"abstract_inverted_index":{"The":[0],"optimal":[1],"circadian":[2,26,105],"rhythm":[3,27,106],"entrainment":[4,28,47,59,73,107],"problem":[5],"has":[6,82],"been":[7],"studied":[8],"based":[9],"on":[10,85,118],"mathematical":[11,115],"models,":[12],"e.g.":[13],"the":[14,22,43,46,52,58,60,69,72],"Kronauer":[15],"model.":[16],"In":[17],"this":[18],"paper,":[19],"we":[20],"study":[21,50,100],"robustness":[23,44],"of":[24,45,71,91,101],"light-based":[25],"under":[29],"model":[30,53,76,116],"parameter":[31,54,77],"perturbations":[32,56],"as":[33,35,88],"well":[34,103],"propose":[36],"a":[37,98,113],"feedback":[38,66],"control":[39,67],"law":[40],"to":[41,75],"improve":[42],"strategy.":[48],"Our":[49],"finds":[51],"whose":[55],"affect":[57],"most.":[61],"We":[62,96],"also":[63],"find":[64],"that":[65,109],"reduces":[68],"sensivitity":[70],"process":[74],"perturbations.Clinical":[78],"relevance-":[79],"Circadian":[80],"misalignment":[81],"negative":[83],"impacts":[84],"health,":[86],"such":[87],"higher":[89],"risks":[90],"cardiovascular":[92],"disease":[93],"and":[94],"cancer.":[95],"present":[97],"numerical":[99],"how":[102],"optimized":[104],"plans":[108],"are":[110],"derived":[111],"from":[112],"generic":[114],"work":[117],"personalized":[119],"cases.":[120]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}